阿仑膦酸钠

FMOC柱前衍生化HPLC法测定阿仑膦酸钠片含量及有关物质4-氨基丁酸

Determination of Alendronate Sodium Tablets and Its Related Substances 4-Aminobutyric by HPLC Pre-column Derivatization with FMOC

阿仑膦酸钠对去卵巢大鼠关节软骨的影响

Effect of Alendronate Sodium on Articular Cartilage of Rat Knee Joint with Osteoporosis

国内外氯酸钠生产消费现状及市场前景柱前衍生HPLC法测定阿仑膦酸钠骨化三醇片中阿仑膦酸钠的含量

Determination of the content of Sodium alendronate in Sodium alendronate and calcitriol tablets by HPLC with precolumn derivatization

目的探讨阿仑膦酸钠（ALN）对髓内脂肪细胞瘦素表达的影响。

Objective To explore the effect of alendronate on leptin expression of adipocytes that were derived from murine marrow stromal cells .

目的探讨阿仑膦酸钠（alendronate，ALN）对去势家兔骨质疏松的预防作用。

OBJECTIVE To investigate the preventive effect of alendronate ( ALN ) on osteoporosis induced by ovariectomy ( OVX ) in rabbits .

目的探讨不同剂量的阿仑膦酸钠（ALN）对卵巢切除大鼠骨密度和骨质量的影响。

OBJECTIVE To investigate the effects of different doses of Alendronate ( ALN ) on bone mineral density ( BMD ) and bone quality in ovariectomized ( OVX ) rats .

目的为了观察糖皮质激素（GC）短期治疗亚急性甲状腺炎（亚甲炎）患者前后血清骨保护素（OPG）的变化和阿仑膦酸钠（ALN）的骨保护作用。

Objective To study the changes of serum osteoprotegerin ( OPG ) in patients with subacute thyroiditis ( SAT ) undergoing glucocorticoid therapy and clarify the roles of alendronate in inhibiting bone resorption .

目的：探讨阿仑膦酸钠（alendronate，ALN）联合四环素（tetracycline，TET）局部应用对延期再植干燥狗牙愈合的影响。

Objective : To investigate the effect of local application of alendronate ( ALN ) combined with tetracycline ( TET ) on the healing of replanted dog teeth after extended dry time .

目的探讨早期应用脉冲电磁场（PEMFs）和/或阿仑膦酸钠（ALN）对脊髓损伤（SCI）后大鼠骨质量的影响。

Objective To explore the effect of early administration of alendronate ( ALN ) and pulsed electromagnetic fields ( PEMFs ) on bone mass of rats after spinal cord injury ( SCI ) .

结果阿仑膦酸钠治疗6个月后，患者腰椎2-4、股骨颈、wards三角及大转子骨密度显著增加，增幅分别达4.1%、2.5%、3.3%及2.4%（均P<0.001）。

Results BMD at Lumbar 2-4 , Neck , Wards and Trochanter sites were significantly increased by 4.1 % , 2.5 % , 3.3 % and 2.4 % res p ectively ( P < 0.001 ) .

48只大白兔建立单侧尺桡骨骨折模型并夹板固定，实验组大白兔给予0.05%阿仑膦酸钠溶液2mL。

All rabbits were prepared into models of forearm fracture and stabilized with splints . In experimental group 0.05 % alendronate solution 2 mL were given , and the normal control group was fed routinely .

阿仑膦酸钠治疗6个月后，腰椎2～4、股骨颈、Wards三角区及大转子部位BMD值有显著上升，增加率分别达49%、34%、53%及36%。

BMD values of Lumbar 2 ~ 4 , Neck , Wards and Trochanter sites were significantly increased by 4.9 % , 3.4 % , 5.3 % and 3.6 % respectively after 6 months of treatment . No change was found in serum calcium concentration .

结论破骨细胞形成增加可能是1型糖尿病骨质疏松的原因之一，阿仑膦酸钠抑制1型糖尿病骨质疏松大鼠体外培养的OLC的形成。

Conclusions The increased number of osteoclast might be one of the reasons for the development of osteoporosis in rat with T1DM , while Alendronate can inhibit in vitro OLCs formation in these rats .

以挥发性的正戊胺作为离子对试剂，采用离子对反相高效液相色谱法，配以蒸发光散射检测器（ELSD）检测，建立了用于阿仑膦酸钠含量测定及相关物质检查的分析方法。

An isocratic liquid chromatographic method with evaporative light scattering detection ( ELSD ) was developed for analysis of alendronate and its related substances which are not retained on non-polar column and lack chromophore for detection .

ig阿仑膦酸钠2.5,5和10mg/kg对小鼠的协调运动和自主活动，麻醉猫的呼吸频率、呼吸深度、平均动脉压、心率及心电图无明显影响；

It was found that alendronate ( 2.5,5 and 10mg / kg , ig ) had no obvious effects on the coordinative motor performance and spontaneous activity in conscious mice , the rate and amplitude of respiration , mean blood pressure , heart rate and ECG in anaesthetized cats .

阿仑膦酸钠对维甲酸所致实验性骨质疏松大鼠的防治作用

Effect of alendronate on osteoporosis in rats induced by retinoic acid

载阿仑膦酸钠骨水泥抑制骨水泥微粒诱导的骨吸收

Alendronate in Bone Cement Inhibiting PMMA Particles Induced Bone Resorption

阿仑膦酸钠治疗伴骨质疏松症的髋部骨折

Clinic effect of alendronate sodium treatment in osteoporosis patients with hip fracture

激素替代疗法联合阿仑膦酸钠治疗绝经后骨质疏松的临床研究

Clinical effect of HRT combined with alendronate on postmenopausal osteoporosis

阿仑膦酸钠、辛伐他汀联合应用治疗大鼠骨质疏松的作用

Effects of alendronate and simvastatin on the osteoporosis in rats

阿仑膦酸钠对老年女性骨质疏松症的疗效

Efficacy of alendronate in treating osteoporosis in old women

阿仑膦酸钠对骨小梁结构特性的作用

Effects of alendronate on trabecular bone structural properties

阿仑膦酸钠对人工关节假体周围骨长入的影响

Effects of alendronate on the periprosthetic bone ingrowth

阿仑膦酸钠治疗37例绝经后骨质疏松症的疗效及观察

Efficacy of Alendronate in 37 postmenopausal osteoporotic women

载阿仑膦酸钠超高分子量聚乙烯力学性能研究

Study on mechanical properties of UHMWPE carrying alendronate

结论载阿仑膦酸钠骨水泥能够释放出阿仑膦酸钠，抑制骨水泥微粒诱导的破骨样细胞的形成和骨吸收作用。

Conclusion The bone cement carrying Alendronate can inhibit PMMA particles induced bone resorption .

间歇应用阿仑膦酸钠促进假体的骨整合

Intermittent Application of Alendronate Promote Osteointegration of Prothesis

阿仑膦酸钠对骨折愈合的影响

The Effect of Alendronate on Fracture Healing

阿仑膦酸钠抑制破骨细胞体外吸收的研究

Alendronate inhibits osteoclastic bone resorption in Vitro

阿仑膦酸钠对大鼠骨关节炎影响的实验研究

Effects of Alendronate on Osteoarthritis in Rats