间隙连接

间隙连接基因Cx43表达对肺癌细胞体内成瘤生长的抑制

Inhibition of in vivo growth of lung carcinoma cells after transfection with gap junction gene Cx43

间隙连接蛋白43在HSV-tk-GCV系统旁观者效应中的作用

The role of gap junction protein connexin 43 in bystander effect in gene therapy

n急性一氧化碳中毒大鼠心脏间隙连接蛋白Cx43的表达

The expression of Gap Junction Protein Cx43 in ACOP rat heart

用westernblot分析和电镜观察心肌细胞Cx43表达和间隙连接。

Cardiac myocytes Cx43 expression and gap junction were characterized by Western blot and electron microscope .

结果显示间隙连接蛋白43在正常肾上腺组织、肾上腺良性腺瘤组织和肾上腺癌中的表达依次降低，彼此之间的差异有统计学意义（P＜0.05）。

Result reveal Cx43 reduce sequentially in normal adrenal tissue , benign adenoma and adrenocortical cancer , the difference between each other is statistical significant ( P < 0.05 ) .

间隙连接细胞间通讯（Gapjunctionintercellularcommunication，GJIC）是相邻细胞间普遍存在的直接通讯方式。

Gap junction intercellular communication ( GJIC ) was the direct communication mode which generally existed between adjacent cells .

用Northern分子杂交和染料传输方法检查间隙连接表达情况，并观察细胞在体外和裸鼠体内生长。

By using Northern blot , dye transfer methods and examinations of in vitro / in vivo growth , stable Cx43 transfectant cells were studied .

方法以高转移性人肺癌PG细胞为材料，该细胞的间隙连接基因Cx43表达抑制，细胞通讯功能缺陷。

Methods A highly metastatic human lung carcinoma cell line PG was used .

大鼠视网膜细胞间隙连接蛋白Cx43的表达

Gap junction protein connexin 43 expressed in the BN rat retina

间隙连接蛋白基因connexin43、ER、PR的表达在子宫平滑肌瘤中相关性研究

The relationship of expression of connexin 43 mrna , cx43 , estrogen receptor and progesterone receptor in human leiomyoma and myometrium tissues

间隙连接蛋白Cx43在卵巢肿瘤中的初步研究

A study on expression of connexin 43 in ovarian neoplasms

间隙连接蛋白Cx43在骨巨细胞瘤和骨肉瘤中表达的研究

Expression of Connexin 43 in Human Giant Cell Tumors of Bone and Osteosarcomas

血管紧张素Ⅱ经AT1受体和ERK1/2上调心肌细胞Cx43间隙连接

Angiotensin ⅱ up-regulates cardiomyocyte Cx43 gap expression via AT_1 receptor and ERK1 / 2

妊娠滋养细胞疾病间隙连接蛋白CX43的表达

Expression of Connexin 43 in Gestational Trophoblast Disease

间隙连接蛋白Cx43和Cx45在体外受精绵羊早期胚胎中的表达

Expression of connexin 43 and connexin 45 in sheep preimplantation embryos fertilized in vitro

目的研究对苯二甲酸（TPA）对NIH3T3细胞间隙连接通讯（GJIC）功能的影响。

Objective To assess the effect of TPA on GJIC function of NIH3T3 cell .

间隙连接蛋白Cx43在人胚肺和肺癌细胞表达的研究

Expression of gap junction protein Cx43 in cultured normal human embryonic lung cells and lung carcinoma cells

用WESTERNBLOTTING分析、代谢标记和免疫沉淀测定、电镜观察心肌细胞Cx43表达、合成和间隙连接。

The Cx43 expression , synthesis and gap junction in cardiomyocytes were characterized by Western blotting , metabolic labeling and immunoprecipitation assay , and electron microscope .

结论间隙连接基因Cx43表达对肺癌细胞有抑瘤作用。

Conclusion Increased expression of gap junction gene Cx43 induced tumor suppressing effects in human lung carcinoma cells .

8-Br-cAMP上调舌癌细胞株间隙连接蛋白基因Cx43表达的研究

Up-Regulation Effect of 8-Br-cAMP on Expression of Connexin Gene Cx43 in Tongue Carcinoma Cell Line

目的：探讨复方藤梨根制剂对高转移性人肺癌细胞（PG）的生长及细胞间隙连接通讯功能的影响。

Objective : To explore the effects of Fufang Tengligen Mixture on growth and gap junction intercellular communication ( GJIC ) of PG cell line .

目的：探讨间隙连接蛋白43（connexin43，Cx43）在舌癌中的表达及意义。

Objective : To investigate the role of connexin 43 ( Cx 43 ) in the development of human tongue carcinoma .

结论体外培养的人RPE细胞表达Cx43，EGF可以减弱细胞间隙连接通讯功能、下调Cx43在人RPE细胞中的表达。

Conclusion Cultured human RPE cell can express Cx43 protein , EGF can decrease the function of intercellular communication and the expression of Cx43 .

目的研究细胞间隙连接蛋白基因connexin43及其蛋白、雌激素受体（ER）、孕激素受体（PR）在子宫平滑肌瘤中的表达，从核酸及蛋白水平探讨三者在子宫平滑肌瘤发生中的相关关系。

AIM To investigate the expression and the roles of connexin 43 mRNA and its protein Cx43 , estrogen receptor ( ER ) and progesterone receptor ( PR ) in human leiomyoma and myometrial tissues .

目的研究卡维地洛对大鼠心肌缺血再灌注损伤、心肌间隙连接通讯（GJIC）及连接蛋白43（CX43）的影响，验证卡维地洛可通过改变CX43磷酸化状态抑制GJIC起到防止心肌再灌注损伤的假设。

Objective To examine the effects of carvedilol on myocardial ischemia and reperfusion injury and on gap junctional intercellular communication ( GJIC ) .

用LY染料传输方法测定细胞间隙连接功能，观察这3组不同浓度的EGF对人RPE细胞缝隙连接功能的影响。

The function of the cell gap junction of human RPE cells was determined by LY methods . And the changes induced by different concentration EGF were also observed .

间隙连接蛋白（Cx）基因在胚胎发育、细胞生长、分化及细胞间信号传递、物质交流等方面起着重要作用，Cx基因的表达及功能异常与肿瘤发生密切相关。

Connexins ( Cx ) plays an important role in embryonic growth , cell proliferation , differentiation , signal transduction and substance communication , etc.

目的：探讨类胡萝卜素对乳腺癌细胞MDA-MB-435S和MCF-7细胞的细胞间隙连接通讯功能的影响。

Objective : To observe the effect of carotenoid on gap junctional intercellular communication of human breast cancer cell of MDA-MB-435S and MCF-7 .

结论Ang-（1-7）通过抑制磷酸化ERK1/2活性增加，从而拮抗AngⅡ上调培养新生鼠心肌细胞Cx43间隙连接。

Conclusion : Ang - ( 1-7 ) antagonizes the effects of Ang ⅱ on up-regulating Cx43 gap junction in cultured neonatal rat cardiac myocytes via inhibiting P-ERK1 / 2 activity increase .

间隙连接通道是相邻细胞之间唯一可以直接进行信息交流的细胞通讯途径。间隙连接蛋白基因（connexins）作为组成间隙连接通道的基本单位，在哺乳动物早期胚胎发育过程中广泛存在。

As the only distinct communication pathway between adjacent cells , connexins exist widely during mammalian preimplantation embryo development .