锥体外系反应

胃复安为胃驱动药，临床上较常用，一般用药都比较安全，但过量可引起锥体外系反应。

Metoclopramide for the stomach-driven medicine , clinical less commonly used , drugs are generally safe , but can cause excessive Extrapyramidal reactions .

最常见的不良反应是锥体外系反应（EPS）。

The most frequent adverse reaction was extrapyramidal syndrome ( EPS ) .

目的：了解利培酮治疗老年期精神障碍患者的用药特点、疗效及锥体外系反应（EPS）。

Objective : To know the application character , efficacy and extrapyramidal side effect ( EPS ) of risperidone in the treatment of late-life psychosis .

氯丙嗪较易引起锥体外系反应（EPS），及胆碱能系统不良反应。

There were more adverse effects in chlorpromazine group than in quetiapine group , especially in extrapyramidal side effect ( EPS ) and in choline system .

结果两组患者均未发现呼吸抑制、锥体外系反应等严重并发症，PCIA组镇痛及时完善持久，总体满意率比对照组明显增高，两组肠蠕动恢复时间没有明显差异。

Results In PCIA group analgesia was timely , perfect and persistent , its satisfactory rate was significantly higher than that in controlled group ( P < 0.005 ), there was no remarkable difference in the recovery time of bowel motility between the two groups .

利培酮不良反应主要为锥体外系反应，2mg组发生率为30%，4mg组为40%，6mg组为82.35%。对心脏、肝肾功能、血液系统几乎无作用，也无镇静作用。

The ADRs rates , mainly EPS , were 30 % , 40 % and 82.35 % respectively for 2 mg , 4 mg and 6 mg groups and no obvious ADRs in heart , liver , kidney , and blood system were observed and there was no sedative effect .

药源性锥体外系反应2265例文献分析

Drug-induced Extrapyramidal Syndrome : Analysis of 2265 Cases

采用右苄替米特和苯海索对抗精神病药物所致的锥体外系反应52例进行双育对照研究。

We carried out a double-blind control study on52 patients with extra-pyramidal side-effects caused by anti-psychotics .

其次，阿立哌唑组不良反应为焦虑、头痛、失眠、胃肠道反应等，未发现有明显的体重增加、锥体外系反应。

The side effects of aripiprazole group were anxiety , headache , sleeplessness and gastro-intestine ais-order .

目的：探讨药物引起锥体外系反应的特点及一般规律。

OBJECTIVE : To discuss the general pattern and characteristics of drug-induced extrapyramidal syndrome ( EPS ) .

主要不良反应是锥体外系反应、便秘或排尿困难、嗜睡或步态不稳、吞咽困难等。

The main adverse drug reactions were extrapyramidal side effect , constipation , dysuria , hypersomnia , gait instability , dysphagia , et al .

结果阿立哌唑对精神分裂症病人有较好的疗效，主要不良反应为轻度的锥体外系反应、头痛、焦虑和失眠。

Results Aripiprazole was more efficacy for treatment of schizophrenia , main side effects of aripiprazole which were found including EPS , headache , anxiety and insomnia .

结论锥体外系反应与氟哌利多有关，即便小剂量用于硬膜外镇痛仍难以避免锥体外系反应，尤其是青少年。

Conclusion The reaction of extrapyramidal system is associated with droperidol , which is difficult to avoid it with low dose during epidural analgesia , especially in teenagers .

结果锥体外系反应60例中有17例，占28.3%，顽固性便秘11例占18.3%，过度抑制11例占18.3%；

Results 17 outer vertebra appeared adverse effect which constituted 28 . 3 % , 11 stubborn constipation constituted 18 . 3 % and 11 over depressed constituted 18.3 % .

结论：天舒胶囊较氟桂利嗪减少偏头痛发作频率和严重程度，具有更持久的预防保护作用，副作用小且无锥体外系反应。

CONCLUSION : Tianshu Capsule could ameliorate the migraine frequency and duration as well as the severity than that of Flunarizine , and had longer prevention effect on migraine without extrapyramidal system responses .

结果：利培酮平均治疗剂量为（2.84±O.71）mg/d，总有效率为87.5%，不良反应主要为锥体外系反应。

Results : The average therapeutic dosage of risperidone was ( 2.84 ± 0.71 ) mg / d , the total efficacious rate was 87.5 % . The main side effect was slight EPS .

结论利培酮与奋乃静治疗精神分裂症疗效相当，但利培酮锥体外系反应较少，患者服药依从性好，值得临床广泛应用。

Conclusion The therapeutic effects of risperidone and perphenazine are equal , but the reaction of extrapyramidal system in group of risperidone is less and better compliance , which can be used widely clinically .

结论利培酮是一种安全有效的抗精神病药物，在改善认知功能和阴性症状方面，利培酮优于氯氮平，少数病例可出现锥体外系反应。

Conclusions : Risperidone is an effective and safe antipsychotic agent , it shows better effect in improving cognitive function and decreasing negative symptoms compared with clozapine , though extrapyramidal side effect may occur in some cases .

利培酮组锥体外系不良反应和内分泌改变的发生均明显高于阿立呱唑组（P均<0.05）。

The incidences of extra-pyramidal symptoms and endocrine change in Risperidone group were obviously higher than those in Aripiprazole group ( P < 0.05 ) .

方法：对入选病例作副反应量表（TESS）、锥体外系副反应量表（RSESE）、不自主运动量表（AIMS）评定。

Method : The patients were chosen to be assessed with TESS , RSESE and AIMS .

方法：利用氟哌啶醇所致小鼠锥体外系不良反应模型，观察其衍生物（F3）的作用；

Method : By using the model of adverse reaction of extrapyramidal system induced by haloperidol ip on mice , to observe the behavior effect of its derivation ( F 3 ) on same dose and administration .

前言：目的了解氟西汀与锥体外系副反应的关系。

Objectives : To find out extrapyramidal side effect associated with fluoxetine .

结论：临床工作者应掌握引起锥体外系不良反应的药物分布规律，安全用药。

CONCLUSIONS : It is essential for clinical practitioners master the distribution patterns of drugs that induced EPS so as to promote medication safety .

药物治疗组8例，心理治疗组6例出现锥体外系副反应，对症治疗后副反应消失。

The side effect of extrapyramidal system occurred in8 cases of the drug therapy group and6 cases of the psychotherapy group respectively , and the side effect disappeared after symptomatic treatment .

目的和方法：用腹腔注射氟哌啶醇（25mg／kg）复制小鼠锥体外系行为不良反应，经相同途径与剂量注入氟哌啶醇季铵盐衍生物（F3），观察其行为变化。

Abstract AIM and METHODS : Using the model of adverse reaction of extrapyramidal system induced by haloperidol ( 25mg · kg - 1 ) upon mice , to observe the behavior of its derivative ( F 3 ) with same dose and administration ;

未见锥体外系症状。主要不良反应是锥体外系反应，30%左右，剂量与疗效之间未发现相关关系。

The major adverse drug reaction was extrapyramidal symptoms ( 30 % ) . The correlation of dosage to therapeutic efficacy was not found .