铁螯合剂

目的：探讨铁螯合剂对大鼠脑出血（Intracerebralhemorrhage，ICH）后脑水肿的治疗作用。

Objective To explore effects of the iron chelator on brain edema after experimental intracerebral hemorrhage ( ICH ) in rats .

【结论】铁螯合剂落叶松皮素通过促进铜绿假单胞菌IV型菌毛颤搐运动，影响该菌生物膜的发育，同时在某种程度上可减弱生物膜菌对磷霉素的耐药性。

【 Conclusions 】 Iron chelator maltol affects the development of Pseudomonas aeruginosa biofilm and can decrease biofilm bacterial resistance to fosfomycin to some extent .

目的探讨采用不同剂量铁螯合剂治疗高量输血重型β珠蛋白生成障碍贫血（地贫）患儿1年后的血清铁蛋白（SF）的变化。

Objective To investigate the change of serum ferritin ( SF ) level in hyper transfusion thalassemia major ( TM ) children treated with different dosage of iron chelator .

为了研究铁螯合剂&去铁胺（deferoxamine，DFO）诱导人白血病细胞株HL-60凋亡时半胱天冬酶-3（caspase-3）活性的变化并探讨DFO诱导凋亡的可能机制。

This study was purposed to observe the changes of caspase-3 activity during apoptosis of HL-60 cells induced by an iron chelator , DFO ( deferoxamine ), and to explore the mechanism underlying apoptosis in HL-60 cells .

某些自由基清除剂和铁螯合剂可以拮抗或减轻豚鼠氨基糖苷类抗生素耳毒性作用，并且有望应用于临床，从而拓宽了AmAn抗感染的适用范围。

However , some kinds of radical scavengers and iron chelators can prevent or attenuate aminoglycoside antibiotic induced deafness , which seems possible to diminish toxicity of AmAn and greatly expand application of AmAn .

对铁螯合剂去铁胺的研究也证实了这一观点。

This is further supported by experiments with the iron chelator desferrioxamine .

铁螯合剂对大鼠脑出血脑水肿的治疗作用

Effect of the iron chelator on brain edema after experimental intracerebral hemorrhage in rats

铁螯合剂诱导白血病细胞凋亡信号转导的实验研究

Experimental Study on the Signal Transduction During Leukemic Cell Apoptosis Induced by Iron Chelator

珠蛋白生成障碍性贫血的铁螯合剂治疗

Thalassemia Treated by Iron Chelator in Children

铁螯合剂长久以来用来治疗体内铁过量的病人，但是关于它作为癌症的治疗药物的研究还处于初级阶段。

The study of iron chelators as cancer chemotherapeutic agents is still in its infancy .

铁螯合剂与银杏叶提取物合用防治顺铂耳毒性

Protective Effect of Deferoxamine and Ginkgo Biloba Extract ( EGb ) on Ototoxicity of Cisplatin

不同剂量铁螯合剂治疗高量输血重型β珠蛋白生成障碍贫血患儿血清铁蛋白的变化

Change of Serum Ferritin Level in Hyper Transfusion Thalassemia Major Children Treated by Different Dosage of Iron Chelator

尽管可见铁螯合剂一去铁胺治疗脑出血的许多资料报道，但除螯合铁直接抑制铁的毒性作用之外，是否尚有其他可能机制目前未见报道。

No data of the other possible mechanisms of deferoxamine except its iron chelation to inhibit iron direct toxication .

运用外源性铁螯合剂，可能是清除细菌生物膜，防治细菌生物膜相关感染的一种新策略；竹醋液可能有用于防治细菌生物膜相关感染的潜力。

Our date suggest that iron chelator and bamboo vinegar should be investigated further as a possible therapeutic agents against biofilm bacterium-associated infections .

各种导致脑水肿的因素可能最终通过影响水通道蛋白4（AQP4）而发挥作用。去铁胺，一种强有力的铁螯合剂，可减轻脑出血后的脑水肿形成。

Deferoxamine ( DFO ) - a potent iron chelator can relieve brain edema resulted from ICH and hemoglobin .

铁离子在脑出血中的损伤机制及铁螯合剂的神经保护作用

The Damage Mechanisms of Iron Ion in Intracerebral Hemorrhage and the Neuroprotective Effects of Iron Chelator