透皮吸收
- 网络transdermal absorption;percutaneous absorption
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结果:薄荷脑和尿素对利巴韦林有非常显著的促进透皮吸收作用(P<0.01)。
RESULTS : Menthol and urea markedly enhanced the percutaneous absorption of ribavirin ( P < 0.01 ) .
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GF和沙林的家兔整体透皮吸收
The comparative research on percutaneous absorption of GF and sarin in rabbits
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目的:研究阿西美辛涂膜剂体外透皮吸收的影响因素,实验观察促透剂种类、浓度以及pH值对体外透皮吸收的影响。
OBJECTIVE To study the effect of different penetration enhancers 、 concentration and pH on the permeation of acemetacin across skin in vitro .
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结论BALB/c裸小鼠比SD大鼠更适合用于体外透皮吸收试验。
Conclusion BALB / c nude mice is more suitable for experiment of extrinsic percutaneous absorption than SD rats .
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目的:比较GF和沙林的家兔整体透皮吸收特点。
Objective : To compare percutaneous absorption of GF and sarin in rabbits in vivo .
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目的:对青藤碱贴剂的透皮吸收数据进行灰色GM(1,1)模型拟合并与相关模型进行比较。
AIM : The transdermal absorption data of sinomenine patch was fitted by grey model GM ( 1,1 ) and compared with other models .
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方法:用TLC扫描法及改良Franz扩散池作透皮吸收实验。
Method s : Improved Franz diffuser was applied to transdermal experiment with TLC scanning method .
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氮酮对人参皂苷Rg1和米诺地尔透皮吸收的影响
Effects of azone on transdermal absorption of ginsenoside Rg_1 and minoxidil
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三七总皂苷中人参皂苷Rg1体外透皮吸收的实验研究
Percutaneous absorption of Rg1 in Panax notoginseng in vitro
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青藤碱贴剂透皮吸收数据的灰色GM(1,1)拟合及与相关模型的比较研究
The transdermal absorption data ' GM ( 1,1 ) fitting of sinomenine liposome patch and comparison with related model Study on the preparation of piroxicam films
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透皮吸收实验用BALB/c无毛小鼠的离体鼠皮,紫外分光光度法检测,并与同浓度的甲硝唑溶液进行比较。
Transdermal absorption ability of metronidazole was observed by using the skin of the bald BALB / c mice and the level of metronidazole was determined by UV-spectrophotometry .
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体内法测定结果表明,小鼠在24h内每小时的透皮吸收平均速率为10.5μg/cm~2。
The average rate of percutaneous absorption in vivo is 10.5 μ g / h / cm ~ 2 for 24h in mise .
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洛美沙星(Lomefloxacin)透皮吸收搽剂中氮酮的最佳浓度
Determination of the Best Concentration of Azone in the Lomefloxacin Liniment of Transdermal Absorbent Preparation
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联合应用NB-UVB与他克莫司对小鼠他克莫司透皮吸收及IL-10表达的影响
Effects of NB-UVB Combined with Tacrolimus on Percutaneous Penetration of Tacrolimus and Expression of IL-10 in Mice
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采用抛物线拟合法建立不同时间下氮酮(Azone)浓度对LMS透皮吸收率的数学模型。
The mathematic model of LMS transdermic absorption rate under different azone concentrations was calculated by the parabolic curve fitting method .
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采用改良Franz扩散池,研究DP脂质体制剂与上市凝胶制剂大鼠皮肤的体外透皮吸收差异。
The difference of in vitro percutaneous absorption of DP formulation and commercial gel formulation in modified Franz diffusion device was observed .
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以零级速率透过皮肤,24h累积透皮吸收率为63.8%。
The test in vitro showed that VCR-T could permeat through mouse skin at zero rate with the cumulative penetrating quality amounting to 63.8 % .
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研制的EMP霜透皮吸收效果好,且对皮肤无刺激性和致敏性,适宜于皮肤外用给药。
The study prepared EMP cream ( O / W ) and explored its percutaneous penetration in vitro and irritation on skin .
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亚油酸甲酯具有一定的透皮吸收能力,但是DMSO的促皮吸收作用不明显。
Methyl linoleate displayed a certain capacity of transdermal absorption , but the role of penetration aid of DMSO was not obvious .
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研究结论证实MPS(多磺酸粘多糖)不但能透皮吸收,而且其活性成分能在各真皮亚层达到有效的治疗浓度。
The results not only confirmed the absorption of MPS but also showed that the active ingredient reaches the individual dermal layers in therapeutic effective concentrations .
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本文用抛物线拟合法建立了不同时间下不同浓度的氮酮对RFP透皮吸收量的数学模型,求得了氮酮对RFP透皮吸收促进作用的最佳浓度为5.70±0.45%。
Calculated by mathematical model , it showed that the optimal concentration of azone was 5.7 ± 0.45 % .
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采用离体裸鼠皮肤,以V-C扩散池和HPLC检测法,研究了阿魏酸的透皮吸收及其影响因素。
The authors have studied the percutaneous absorption and the influential factors of ferulic acid by V-C diffusion cell and HPLC with separated rat skin .
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方法黄芩苷的测定采用分光光度法。透皮吸收研究以改进型Franz扩散池为工具,比较黄芩苷渗透小鼠、裸鼠、家兔、大鼠、人体皮肤的透皮速率常数。
Methods Improved Franz-call was used for the transdermal study , and the transdermal speed constants of baicalin per five kinds of animal skin were compared .
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目的观察兔单次皮肤外用美洛昔康(meloxicam,Mel)凝胶的透皮吸收及药物在体内的动态过程,估算其药动学参数。
AIM To study the course of percutaneous absorption and pharmacokinetics of meloxican ( Mel ) gel which used in skin of rabbit .
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结果:Tw80可促进喷昔洛韦的透皮吸收,不同浓度PG对喷昔洛韦的透皮吸收影响较小。
Result : Tw80 could enhance transdermal absorption of penciclovir gel , PG had litter effect on absorption .
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用此模型准确求得氮酮对LMS透皮吸收的最佳浓度是3.05±0.57%,同时证明氮酮对LMS有显著的透皮吸收作用。
The optimal concentration of azone for enhancing transdermic absorption of LMS was 3 . 05 ± 0 . 57 % . Cutaneous penetration effect of LMS exerted by azone was significant .
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方法采用改良Frans扩散池进行体外透皮吸收实验。
Method The in vitro skin permeation experiment was conducted by using modified Franz diffusion cell .
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用Infiltrator浸壁球囊导管在体转基因的实验研究尼莫地平透皮吸收实验中渗透屏障的对比
Gene transfer in vivo with infiltrator intramural catheter Comparison of Infiltrator Barrier in Nimodipine Transdermal Therapeutic System
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不含助渗剂的对照组24h透皮吸收率为20.7±4.4%。提示樟脑对水杨酸和氟尿嘧啶有促皮渗透作用。
Respectively , while that of 5-Fu alone was 20.7 ± 4.4 % , These data indicate that the camphor has the effect of pentration enhancer on skin permeation of salicylic acid and 5-Fu .
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方法:采用改良Franz扩散池法,进行大鼠离体皮肤透皮吸收试验,以丹皮酚含量为指标,采用HPLC法定量检测透过的丹皮酚量。
Methods : The percutaneous absorption test was performed on excised rats skin in improved Franz diffusion cell . The penetrative amount of paeonol was determined quantitatively by HPLC and the content of paeonol as a marker .