软骨蛋白聚糖

谷胱甘肽对Cu~（2+）-H2O2导致关节软骨蛋白聚糖降解的影响

Effect of glutathione on degradation of proteoglycan of articular cartilage treated by cu ~ ( 2 + ) - h_2o_2

在温育的介质中加入H2O2，也可使关节软骨蛋白聚糖降解增高，Cu~（2+）或Co~（2+）对此有显著促进作用，其它过渡金属则作用不明显。

Addition of H2O2 to the incubation medium also enhanced the proteoglycan degradation of articular cartilage , and this effect was promoted significantly by Cu2 + or Co2 + .

目的构建人软骨蛋白聚糖（aggrecan）探针，应用于整复外科研究中Northern法对AggrecanmRNA表达水平的检测。

Objective To construct Northern hybridization probe for quantitative analysis of aggrecan mRNA expression level in plastic surgery research .

活性氧及过渡金属对关节软骨蛋白聚糖降解的影响

Effects of Reactive Oxygen and Transition Metals on Degradation of Articular Cartilage Proteoglycan

目的：观察长时间异常应力环境下兔颈椎软骨终板蛋白聚糖（PG）含量及组分的变化，探讨颈椎间盘退变的发生机制。

Objective : To observe the changes of proteoglycan ( PG ) components of cervical cartilage endplate under long term abnormal stress condition and discuss the possible pathogenesis of disc degeneration .

异常应力环境下兔颈椎软骨终板蛋白聚糖变化的实验研究

An Experimental Study on Changes of Proteoglycan of Cervical Cartilage Endplate under Long Term Abnormal Stress Conditon in Rabbit

目的探讨健骨胶囊对骨性关节炎模型动物关节软骨组织中蛋白聚糖含量的影响。

To study the effect of Jiangu granule ( JGG ) on quality of bone in model rats with osteoporosis .

结论T-2毒素对软骨细胞Ⅱ型胶原蛋白和蛋白聚糖合成有明显的抑制作用，微量元素硒对T-2毒素引起的软骨细胞蛋白聚糖改变有一定保护作用。

Conclusion T-2 toxin can obviously inhibit aggrecan and collagen ⅱ synthesis in human chondrocytes , and selenium can partly antagonize the inhibitory effects of T-2 toxin on aggrecan .

藩红花O染色显示软骨细胞周围存在不断增大的橙红染区，提示软骨细胞分泌蛋白聚糖含量持续增加。

Safranin " O " staining around the cells increased area and in intensity throughout the culture time , indicating the continuous increased quantity of proteoglycan .

在温育的小牛关节软骨切片介质中加入黄嘌呤氧化酶/次黄嘌呤活性氧产生系统，可使关节软骨蛋白聚糖的降解显著增高。

When the articular cartilage slices of new born calf were incubated in the presence of xanthine oxidase and hypoxanthine , an oxygen radical generating system , the degradation of cartilage proteoglycan was increased significantly .

应用小牛关节软骨短期器官温育的方法，研究了谷胱甘肽（GSH）对Cu~（2+）-H2O2导致关节软骨蛋白聚糖（PG）降解的影响。

The effect of glutathione ( GSH ) on degradation of proteoglycan ( PG ) of articular cartilage treated by Cu2 + - H2O2 was studied with incubating articular cartilage slices of new born calf .

NO是参与关节软骨细胞分化和凋亡的重要调节因子，其可抑制软骨细胞增殖，诱导软骨细胞凋亡，抑制软骨细胞对蛋白聚糖、Ⅱ型胶原的合成，促使软骨细胞外基质分解。

NO can inhibit the proliferation of chondrocytes and induced chondrocytes apoptosis 、 inhibit the synthesis of ⅱ collagen and proteoglycan by chondrocyte 、 and promote the decomposition of cartilage extracellular matrix .