药物释放

明胶/海藻酸钠复合体系用于pH敏感智能药物释放体系的研究

On gelatin / sodium alginate used as pH-sensitive drug delivery system

国外从事药物释放系统（DDS）研究的主要机构及其技术平台和产品

Foreign companies in drug delivery system development and their platforms and products

双亲水性超支化接枝共聚物的pH响应性药物释放

Drug release property of a pH-responsive double-hydrophilic hyperbranched graft copolymer

pH及电位敏感的聚苯胺膜用于药物释放

PH and Potential Sensitive Film of Polyaniline for the Use of Drug Release

研究了载药纳米球在pH为7.4的磷酸盐缓冲液中的药物释放行为。

Drug release behavior was studied in the pH 7.4 phosphate buffered saline .

发现在微酸性环境下药物释放量大于正常pH值环境的释放量。

Found that the release of the drug released in a slightly acidic environment is greater than the normal pH.

超声在药物释放中的应用使得药物可以在特定目标区域进行释放和作用，实现超声无损检测（ultrasonicnon-destructivetesting，NDT）和治疗。

Ultrasound used on drug particles target specific areas for drug release and action , realizing ultrasonic non-destructive testing .

结果表明，药物释放性能与载药量、介质的pH值、环境的温度有关。

The results showed that drug release performance was related to contents of 2,4-D in the tablets , pH value of medium and environment temperature .

根据刺激因素可以分为光、电、磁、热、pH等可控药物释放体系。

Based on the stimuli ways , they generally can be divided into light , electro , magnetic , thermal , and pH-responsive controlled drug release systems .

P（NIPAM-DADMAC）微凝胶的合成、表征及药物释放

Synthesise and Characterization of P ( NIPAM-DADMAC ) Microgel and Drug Release

药物释放系统（DrugDeliverySystems，DDS）已成为药学领域的重要发展方向，随之而来对药物载体及材料的研究也就愈加显得格外重要。

Targeted Drug Delivery Systems ( TDDS ) have been an important developing drug field , so it is necessary to develop the research of drug carrier and material .

考察分别载有BSA和Vc的微球-支架在动/静态条件下的药物释放行为。

The release behavior of BSA and Vc from the microspheres incorporated PLGA scaffold under dynamic and static condition was studied .

随CS浓度或ALG浓度的增大，药物释放速率减缓；

With the increase of the concentration of CS or ALG , the LMWH-releasing rate decreases ;

药物释放初期为Fick型扩散释放，释放后期为指数函数的形式释放。

The releasing of it at beginning stage was Fick - diffusion mode .

人工神经网络预测氟比洛芬HPMC缓释片的药物释放

Prediction of in vitro Drug Release from Flurbiprofen-HPMC Sustained - release Tablets by Artificial Neural Network

缓释效果与EC量和固体分散体的粒径有主要关系，药物释放速率随EC用量和粘度增加而减小；固体分散体粒径越小药物体外释放速率越快；

But prolongation of drug release was primarily associated with an increase in amount of ethylcellulose and particle size rather than the viscosity grade of ethylcellulose .

为了研究磁性微囊（MMC）药物释放的时空控制方法，我们用复乳化法研制了MMC。

In order to study spacetime-controlled magnetical drug release , the magnetic microcap-sule ( MMC ) was prepared by using multiple emulsion process .

体外药物释放机制符合Higuchi方程；

The mechanism of the in vitro release was shown to conform to Higuchi equation .

结果表明，HPMC粘度增加使药物释放滞后时间延长，但高粘度HPMC会导致药物释放无明显突跃点；

The results showed that the lag time before drug release was lengthened with the increase of the viscosity grade of HPMC .

体外释放度考察：试验结果表明该制剂符合固体药物释放度的要求，且pH对制剂的释放度影响不显著。

The contents of the vitro release technology show that the praeparatum meet the requirements of release of solid drugs and the PH have little effect to the release of praeparatum . 4 . The study of quality standard .

同时，还研究了投药量对PMT的影响及PMT的体外药物释放行为。

At the same time , the influences of the drug-fed amount on PMT and release behavior in vitro of PMT were investigated .

目的评价自固化磷酸钙骨水泥（Calciumphosphatecement，CPC）载药妥布霉素的体外抗菌活性和植入兔体内后的药物释放特性。

Purpose To evaluate the calcium phosphate cement ( CPC ) characteristics about the drug release from the tobramycin-impregnated self-setting CPC in vivo after implanting it into rabbit 's femora and bacteria inhibitory of it in vitro .

定点释放药丸系统是一种基于微型机械电子系统（MEMS）的工程药丸，无创地实现了消化道内定点药物释放。

Abstract : Site-Specific Delivery Capsule ( SSDC ), an engineered capsule based on MEMS technology , is a new method to realize non-invasive drug delivery to the selected sites of the human gut .

通过TEM，LLS和UV对胶束的形貌和温敏性进行了研究，同时考察了负载布洛芬胶束的药物释放。

The morphology and thermo-sensitive of micelles were studied by TEM , LLS and UV , at the same time the drug release of micelles which loaded ibuprofen were investigated .

结果：溶出介质1.0%和0.5%的十二烷基硫酸钠（SDS）水溶液可以满足漏槽条件，但药物释放较快，固体分散体间的溶出行为差异不明显；

Results : The drug release rate from four kinds of nitrendipine solid dispersions was quite faster in 1.0 % or 0.5 % SDS solutions than in 0.3 % SDS solution .

这项研究清楚地表明，PEO的矩阵产生一个潜在的倾销剂量没有迹象显示在水和水含酒精媒体一致的药物释放。

This study clearly indicates that PEO matrices produces consistent drug release in water and in hydro-alcoholic media with no signs of a potential dose dumping .

负载了DOX的磁性空心球和磁性介孔球的药物释放都具有明显的突释阶段和缓释阶段。

For magnetic hollow spheres and magnetic mesoporous spheres , the DOX drug release both have obvious sudden release stage and slow release stage .

当PDN与EC的比值在1：1～3：5之间时，PDN加入量的增加对药物释放的影响较为显著。

When the ratio of PDN : EC was between 1:1 and 3:5 , the quantity of PDN showed significant effects on the sustained release .

USP规定的片剂溶出试验被广泛用于医药工业中药物释放过程的验证和处方筛选。

The USP tablet dissolution test is an analytical tool used for the verification of drug release processes and formulation selection within the pharmaceutical industry .

人工神经网络预测别嘌醇HPMC缓释片药物释放D-苯丙氨酸和别嘌醇是两种具有重要药用价值的化合物。

Using Artificial Neural Network ( ANN ) to quantitatively predict allopurinol release from HPMC sustained release tablets D-phenylalanine and Allopurinol have been widely applied in the pharmaceutical field .