药物协同作用

目的探讨低剂量棉酚和甾体激素联合用药发挥抗男性生育的药物协同作用。

Objective To study the synergistic effect on male anti fertility of a combined regimen of lowdoes gossypol with steroid hormones .

结论：艾迪注射液具有直接抗肿瘤作用，对化疗药物协同作用的机制可能与其诱导细胞凋亡有关。

Conclusions : Aidi has a direct anticancer effect and the synergetic antiproliferative effect with chemotherapy drugs may be relative to its cell apoptosis-inducing .

同时还与转基因肿瘤疫苗及抗癌药物协同作用，增强抗癌效果。

In addition , through the combination of allicin treatment with gene modified tumor vaccine as well as antitumor drugs , the antitumor effect can be enhanced significantly .

如果作为载体材料，可以与药物协同作用，提高治病效率。

If they can be used as the materials of drug carriers , it will be more effective to treat a disease by the cooperation of carriers and drugs .

另外，在TB实验动物模型中，SQ109还显示出与其他肺结核药物具有协同作用。

In addition , SQ109 has been shown to synergize with other TB drugs in experimental animal models of TB .

结论NS398可以增强顺铂对肺腺癌细胞增殖的抑制作用，两种药物具有协同作用。

Conclusion NS-398 can improve growth inhibition of cisplatin on lung adenocarcinoma cells , and the two agents act in synergistic way .

我们重点关注了金棒的光热效应和顺铂药物的协同作用，并由此带来的增强的抗肿瘤效果。

We focus on the synergic effect of gold nanorods and cisplatin , and their antitumor effects .

结论微量镇痛泵镇痛能维持稳定的血药浓度，利用多种药物的协同作用。

Conclusion The analgesia pump could maintain the drug concentration with coordinating drug to reach the analgesia effect .

目的研究稀土元素的生物化学作用和无机、有机抗肿瘤药物的协同作用。

Aim To study the biochemistry of lanthanides , the cooperative action of inorganic and organic anti - tumor drugs .

血小板型PLA：与具破坏细胞壁功能的杀菌类药物有协同作用，与抑菌类药物合用受到拮抗。

The effects of the PLA2 bactericidal activity were synergistic with cell-wall active antibacterial drugs , antagonistic with bacteriostatic antibacterial drugs .

目的：充分发挥联合用药过程中药物的协同作用，减少不良反应，减轻患者的经济负担。

Objective Reduce the lousy reaction and the economic burden of patients by making full use of the combined usage of the medicine .

同步荧光研究表明，药物之间的协同作用影响BSA的构象。

The synchronous fluorescence spectra indicated that the effect of synergism affected the conformation of BSA .

实验结果表明：两种药物间存在协同作用，导致药物与BSA结合稳定性下降，能够转运并产生药效的游离型药物含量增加，药效增强。

The synergism between LOM and OFL results in both the reduction of the binding stability between drugs and BSA and the increase of the free drug concentration , which will increase the efficacy of drugs .

在动物试验中，苦参碱显示了与化疗药物5-Fu的协同作用。苦参碱的抗肿瘤活性还与抑制环氧化酶-2及特异性诱导拓扑异构酶Ⅰ表达相关。

In an animal experiment , Matrine and 5-fluorouracil showed synergistic effects on tumor growth . Other studies revealed that the anticancer effect of Matrine was associated with the inhibition of COX-2 and the up-regulated expression of topoisomerase I .

端粒酶催化亚基脱氧核酶可显著抑制人肺腺癌A549/DDP耐药细胞的生长，并且与化疗药物顺铂有协同作用，提示端粒酶有可能成为耐药肿瘤细胞新的治疗靶标。

It is suggested that telomerase might be a new target for the treatment of drug-resistance lung cancer cell .

合理的联合用药可以发挥药物间的协同作用，在提高疗效的同时，还可以降低药物浓度。

Reasonable combination of drugs may bring about synergistic effect , which can not only improve the effect but also decrease the drug concentration .

本研究发现活血药与益气药合用对基因蛋白的影响优于单用活血药或单用益气药，证明两类药物有明显协同作用。

The prescript of reinforcing Qi and activating blood has stronger effects on the expression of IEGS proteins and apoptosis related proteins than either drug of reinforcing Qi or drug of activating blood .

以中兽医理论为指导，根据药物之间的协同作用，设计了两种方案，采用正交实验设计，对其开展了中药组方的优化研究。

Under the guidance of Chinese traditional veterinary theory , two prescriptions of traditional Chinese medicine were prescribed according to the synergistic action between every sensitive herb , and developed its optimizing research by orthogonal experimental design .

再者麻醉可导致一定的损伤，此损伤有可能与致心肌损伤药物之间有协同作用，两者同时合用甚至可产生不可逆的组织损伤，使得麻醉动物的一些实验结果难以重复。

Moreover narcotics may have synergism with myocardial injury drugs , and combination of them may cause irreversible injuries , and therefore , the results derived from anaesthetized animal are usually difficulty to replicate in the same animal .

研究结果证明，某些BRMs可直接抑制K-562细胞，与化疗药物并用有协同作用。这种协同作用对K-562/ADM细胞尤其明显。

These results suggested that some kinds of BRMs can inhibit K-562 cell line directly and have synergistic inhibitory effects with chemotherapeutic drugs on K-562 cell line , especially on K-562 / ADM cell line .

化疗药物与细胞因子协同作用引起小鼠T淋巴瘤细胞凋亡

Synergistic Induction of Apoptosis by Chemotherapeutic Drugs and Cytokines in Mouse T-Lymphoma Cell Line

方法采用MTT法测定药物对细胞增殖的抑制率和药物间的协同抑制作用；

METHODS The inhibition of cell proliferation was determined by MTT assay and cell cycle was determined by flow cytometry .

为了了解尼克霉素Z抗真菌的活性，我们进行了尼克霉素Z体外对白念珠菌、皮肤癣菌的药物敏感性试验，同时还研究了尼克霉素Z与其它抗真菌药物的协同作用。

To investigating the antifungal activity of nikkomycin Z , we conduct in vitro susceptibility testing of nikkomycin Z against Candida albicans and Dermatophytes . At the same time , we observed synergism between nikkomycin Z and the other antifungal drugs .

在临床治疗药物中，非竞争性的非核苷类逆转录酶抑制剂（NNRTIs）具有高效低毒、与其它药物协同作用、作用机制明确以及结构多样性等特点，但是极易产生耐药性。

Non-nucleoside reverse transcriptase inhibitors ( NNRTIs ) with structural diversity have , in addition to other kinds of drugs , gained a significant place in the treatment of HIV-1 infections because of their low toxicity , high potency , and statistical synergy with other anti-HIV drugs .