药物分布

理想的药物分布应该是，目的药物有选择性地、集中地分布到病变部位，并在必要时间内维持一定浓度，即具有靶向性。

The ideal distribution of drugs is that they can distribute selectively in the pathological site and keep at a level at some time .

维生素K1注射乳在小鼠体内的药物分布评价

In vivo distribution of vitamin K_1 emulsion for injection in mice

由于血液灌注差异、组织结合力、局部pH值和细胞膜通透性差异等的不同，药物分布一般也是不均匀的。

Distribution is generally uneven because of differences in blood perfusion , tissue binding , regional pH , and permeability of cell membranes .

引起ADRs的药物分布以抗生素的品种数最多，而较为严重的ADRs以解热止痛药及器官移植药发生率为高。

Most ADRs were caused by antibiotics and the serious ADRs were associated with antipyretics and analgesics and drugs used for organ-transplantation .

荧光成像研究发现SLN可促使药物分布于表皮层，表明P-SLN具有表皮靶向性。

The fluorescence imaging found that P-SLN resulted in the local distribution of podophyllotoxin in epidermis and showed an epidermal targeting ability .

观察比对MDMA染毒家兔生命体征变化，并对急死与延缓死亡动物体内药物分布进行研究。

To observe and compare the changes of vital signs about MDMA-administrated rabbit and study the distribution in the body of suddenly and delayed dead animals .

~（125）I-IL－2脂质体及游离~（125）I-IL－2通过小鼠尾静脉给药后，观察其在主要脏器中的药物分布及血药浓度-时间曲线。

After mice were intravenously injected with 125I-IL-2 liposome and free 125I-IL-2 , the drug distribution in their main organs and drug concentration - time curve were observed .

目的检测阿霉素毫微粒（NADM）经肝动脉灌注后，在大鼠体内的药物分布，并与游离阿霉素（FADM）相比较。

AIM To determine the body distribution of nanoparticle associated adriamycin ( NADM ) after administration into the hepatic artery of rats , and to compare it with that of free adriamycin ( FADM ) .

目的：探讨引起药疹的药物分布情况。

Objective : To make clear which drugs can cause drug eruption .

兔眼前房注射贝伐单抗的药物分布及毒副作用的实验研究

Distribution and Toxic Effect of Intracameral Injection of Bevacizumab in Rabbit Eyes

兔眼内直肌注射肉毒杆菌毒素水凝胶的药物分布

Toxin disposition following injection of botulinum toxin gel into medial rectus in rabbits

灯盏花素不同给药途径脑内药物分布的比较

Comparison of the distribution of breviscapine in the brain by different administration routes

兔眼青光眼滤过性手术中应用丝裂霉素后眼组织中的药物分布

Mitomycin C concentrations in rabbit ocular tissues after topical administration during glaucoma filtration surgery

小肠内药物分布与吸收模型的解析解

An analytical solution for the model of drug distribution and absorption in small intestine

YH-8在主要脏器的药物分布顺序为：肠肝肺肾心脾。

The order of drug distribution in the main organs was : intestine liver lung kidney heart spleen .

目的研究兔舌内植入顺铂植入剂体内药物分布特征。

OBJECTIVE To study the distribution of cisplatin in rabbit after the cisplatin-implants were implanted into rabbit tongue .

但对心脏中的药物分布没有显著性的影响，而肝脏中的药物蓄积量显著降低。

But the drug accumulation was lower than the 9-NC solution in liver with no significant change in heart .

使用弧形针分段注射办法，建立球状、椭球状药物分布的注射治疗计划数学模型。

By means of arc-needle step-by-step sector-shapely , we created mathmatical model according to ball-shape and ellipsoid-shape drug distribution .

结论：掌握引起血小板减少的药物分布规律，确保用药安全。

CONCLUSION It is important to handle the distributive axiom of drug induced thrombocytopenia for the safety of medication .

中枢神经系统的血液灌注极佳，一般说来，通透性是药物分布速率的主要决定因素。

Because the CNS is so well perfused , permeability is generally the major determinant of the drug distribution rate .

表观分布容积和血浆非结合分数是药物分布中用得最广的参数。

The apparent volume of distribution and the unbound fraction in plasma are the most widely used parameters for drug distribution .

结果：骶前孔阻滞疗法，影像学观察药物分布及临床效果优于其他相关方法。

Result : The an-terial sacral foramen block was better than other methods on photographes for medicine fully distribution and clinical effect .

[目的]介绍弧形套针的旋转分段注射的办法，解决药物分布模合肿瘤靶区的问题。

Purpose To solve the problem of drug well-distribution into tumor target , we introduce a new method of injection using an arc-sheath-needle .

结论：临床工作者应掌握引起锥体外系不良反应的药物分布规律，安全用药。

CONCLUSIONS : It is essential for clinical practitioners master the distribution patterns of drugs that induced EPS so as to promote medication safety .

目的考察聚乳酸相对分子量对利福平聚乳酸微球形态、载药量及微球中药物分布状态的影响。

Aim To discover the effect of molecular weight of polylactic acid on the shape , drug content and drug distribution state of rifampicin polylactic acid microspheres .

一些药物分布于脂肪；另外一些药物则停留于细胞外液；还有一些药物则牢固地与一些特殊组织结合，通常是肝脏和肾脏。

Some drugs go into fat , others remain in the ECF , and still others are bound avidly to specific tissues , commonly liver or kidney .

不过，如果血浆浓度监测时间够长的话，你就会发现药物分布的第三相，此时，药物便缓慢地从脂肪组织释放出来。

However , if plasma concentration is monitored long enough , a third phase of distribution , in which the drug is slowly released from fat , can be distinguished .

以液液萃取&反相高效液相色谱法研究SD大鼠静脉注射虎杖苷后药物体内分布及排泄情况。

The distribution of PD in rats was studied .

PET是根据正电子湮灭辐射原理，利用符合探测技术检测正电子药物的分布情况，采集的信息通过计算机处理后显示出靶器官的断层图像并给出定量生理参数的核医学设备。

PET is a nuclear medical equipment which can get traverse image and quantitative parameter , and according to the principle of annihilation coincidence detection .

目的观察兔玻璃体腔注射与球周注射125I-神经生长因子（NGF）后眼部各组织药物含量分布。

Objective To observe the distribution and concentration of125I-nerve growth factor ( NGF ) in rabbits ′ eyes after intravitreal injection and posterior juxtascleral injection .