腺苷蛋氨酸

腺苷蛋氨酸与前列腺素E1联合治疗慢乙肝并重度黄疸及肝纤维化的临床研究

A Clinical Study of ademetionine Combined with PGE1 on the treatment of Chronic hepatitis B with severe jaundice and hepatic fibrosis

腺苷蛋氨酸治疗慢性肝病伴胆汁淤积的临床观察

Clinical study of ademetionine in the treatment of chronic hepatitis with cholestasis

细胞内砷代谢和DNA甲基化都需要S-腺苷蛋氨酸作为甲基供体。

S-adenosylmethionine is required as methyl donor for both arsenic metabolism and DNA methylation .

S-腺苷蛋氨酸的这些作用可能有益于LPS诱导的肝损伤的临床治疗。

In a word , S-adenosylmethionine may be beneficial to LPS-induced liver in-jury in clinical treatment .

RP-HPLC测定腺苷蛋氨酸注射用溶剂中赖氨酸的含量及有关物质

Determination of Lysine and Related Compounds by RP-HPLC

腺苷蛋氨酸在肝癌TACE围手术期治疗中的疗效

Efficacy of S-adenosylmethionine in the perioperative liver TACE treatment

48只SD大鼠随机分为4组（每组12只）：正常对照组、模型组、腺苷蛋氨酸低及高剂量组。

48 female SD rats were randomly divided into 4 groups , control , model , low dose and high dose SAM groups .

腺苷蛋氨酸治疗药物性肝损害疗效与血液中GSH变化关系

Relationship between changes of glutathione and liver function in serum in patients with drug liver lesion with ademetionine treatment

本文观察了白细胞介素1（IL1β）和硫代腺苷蛋氨酸（SAM）对培养的肥大软骨细胞蛋白多糖（PG）分解代谢及基质金属蛋白水解酶（MMP）活性的影响。

Effect of interleukin-1 ( IL-1 β) on degradation of proteoglycan and metalloproteinase ( MMP ) activity in rabbit hypertrophic chondrocyte cultures was examined .

结果：S-腺苷蛋氨酸组患者临床症状、体征的缓解，血清生化指标如转氨酶、胆红素、碱性磷酸酶的下降均较对照组显著（P0.05）。

Results : The improvement of clinical symptoms and signs , serum biochemical parameters such as aminotransferase , bilirubin , alkaline phosphatase in SAMe group were more significant than those in SAMe group ( P 0.05 ) .

S-腺苷蛋氨酸（简称SAM）是生物体内的重要的次级中间代谢产物，通过转甲基、转丙氨基、转硫等作用参与生物体大量生化反应，具有广泛的生理作用。

SAM is an important intermediate metabolites in the organism . Through the transmethylation . turning C amino and transsulfuration . SAM involved a lot of biochemical reactions , so SAM has a wide range of physiological function .

【方法】已克隆S-腺苷蛋氨酸脱羧酶、鸟氨酸氨基转移酶、甜菜碱脱氢酶3个基因和内参基因的基础上，应用定量PCR技术，对这3个基因在不同胁迫时间下的表达水平进行分析。

[ METHOD ] In this paper , three gene S-adenosylmethionine decarboxylase ( SAMDC ), ornithine aminotransferase ( OAT ) and betaine aldehyde dehydrogenase ( BADH ) plus one house-keeping gene had been cloned and their expression levels under different stresses were evaluated by real-time PCR technique .

目的：构建人S-腺苷蛋氨酸脱羧酶（SAMDC）的α亚基的原核表达载体，诱导该质粒在大肠杆菌中表达并纯化表达的重组蛋白。

Objective : To construct the prokaryotic expression plasmid of human S-adenosylmethionine decarboxylase ( SAMDC ) α subunit , and to induce and purify the recombined SAMDC - α protein .

人S-腺苷蛋氨酸脱羧酶α亚基的克隆、表达与纯化

Cloning , expression and purification of human S-adenosylmethionine decarboxylase gene α subunit

S-腺苷蛋氨酸治疗慢性重型肝炎临床观察

Clinical Observation of S-adenosylmethionine in Treatment of Chronic Severe Hepatitis

腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症60例

S-adenosylmethionine Treatment of Intrahepatic Cholestasis of Pregnancy Clinical Observation of 60 Cases

腺苷蛋氨酸治疗药物性淤胆型肝炎的疗效观察

Therapeutic effect of ademetionine in patients with cholestatic hepatitis induced by drugs

腺苷蛋氨酸对新生鼠肝脏葡萄糖醛酸基转移酶活性的影响

Effect of Ademetionine on the Glucuronosyltransferase Activity in Infant Mice 's Liver

结论腺苷蛋氨酸治疗药物性肝病具有较好的疗效。

Conclusion Adenosylmethionine can exert significant therapeutic effect on drug induced liver diseases .

丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗妊娠肝内胆汁淤积综合征临床效果分析

Analysis of combination of transmetil with ursodesoxycholic acid treating intrahepatic cholestasis of pregnancy

重组腺苷蛋氨酸合成酶酶促反应条件的研究

Study on enzyme catalysis conditions of recombinant S-adenosylmethionine synthetase

腺苷蛋氨酸治疗肝功能损伤的临床疗效观察与分析

Observation and Analysis on Therapeutic Efficacy of Ademetionine in Patients with Liver Function Injury

破碎酵母释放腺苷蛋氨酸的研究

The study on releasing adenosylmethionine by breaking yeast

S-腺苷蛋氨酸和叶酸抑制同型半胱氨酸诱导的海马神经细胞凋亡

Study on inhibition of S-adenosyl methionine and folate on homocysteine-induced apoptosis of hippocampal neurons

腺苷蛋氨酸联合谷胱甘肽治疗慢性乙型肝炎的效果评价

Evaluation of efficacy of glutathione combined with ademetionine in treatment of hepatitis B patients

腺苷蛋氨酸治疗慢性黄疸型病毒性肝炎40例

40 Cases of chronic Icterohepatitis treated by ademetionine

高产蛋白酶米曲霉的选育高产腺苷蛋氨酸菌株的诱变选育及培养方式研究

Study on screening the strain yielding highly s-adenosylmethionine by complex mutation and its culture manner

产腺苷蛋氨酸酵母菌株的选育

Screening and breeding of S-adenosylmethionine producing yeast

腺苷蛋氨酸临床应用安全，具有较高的改善肝功能损伤的价值。

Ademetionine is safe in clinical application with the high value in improving liver function injury .

熊去氧胆酸联合腺苷蛋氨酸治疗戊型肝炎合并重度黄疸疗效观察

Clinical observation of Ursodeoxycholic acid combining Ademetionine in treatment of viral hepatitis E patients with severe jaundice