脂褐质

大鼠补硒后血谷胱甘肽过氧化酶，维生素E和脑脂褐质的变化

Effects of Se-enriched diets on serum ve , blood GSH-Px and brain lipofuscin in Hyperlipemia Rats

结果：药物预防组和药物治疗组小鼠皮肤SOD活性明显增高，脂褐质含量明显降低；

Results The chemoprophylaxis group and the medication group indicate an obvious increase of SOD activation in mice skin and of a reduction of lipofuscin content .

维生素C对暴露于臭氧环境中小鼠心脑脂褐质水平的影响

Effect of Vitamin C on Lipofuscin in Mice Exposed to Ozone

方法①用过氧化氢（H2O2）诱导DNA损伤，采用单细胞凝胶电泳方法测定DNA氧化损伤程度，同时测定大鼠血清丙二醛（MDA）和脂褐质（LPO）的含量；

Methods DNA damage was induced by H2O2 , then the extent of damage was determined by single cell gel electrophoresis technique ( SCGE ) . The contest of MDA and LPO of rat serum were measured by biochemical method .

脑匀浆中MDA及脂褐质含量在幼龄期时无差异，至中龄时，实验组含量显著低于对照组（P＜0.01）。

The content of lipofuscin and MDA in the brain homogenate had no change at the early-aged of the two groups , but they were much lower in the TAU group than those of the control group at the middle-aged ( P < 0.01 ) .

目的：报道4例成人型神经元蜡样质脂褐质沉积症（Kufs病）的临床、超微结构及影像学特点。

Objective : To report 4 cases of Kufs disease .

方法采用TBA法、NBT法和荧光法，分别测定小鼠心、肝、肾、脑组织中MDA含量、SOD活性及脂褐质含量。

Methods Contents of malon-dialdehyde ( MDA ), superoxide dismutase ( SOD ) and lipofuscin in the heart , liver , brain and kidney of mice were measured using TBA , NBT and fluorescent technique respectively .

若连续灌胃28d，可使亚急性衰老小鼠血中过氧化脂质（LPO）含量及心肌脂褐质含量明显降低，并明显提高皮肤羟脯氨酸含量。

In addition , CASE ( 8.0 g / kg , ig × 28d ) might decrease serum lipoperoxides and myocardial lipofuscin contents and raise skin hydroxyproline content in subacute aging model mice .

模型组腹主动脉脂褐质荧光强度显著高于对照组（P005）。

The fluorescence intensity of lipofuscin of abdominal aorta in model group was higher than that in model group ( P0.05 ) .

目的报道2例成年型神经元蜡样质脂褐质沉积症（ANCL）临床特点和病理改变。

Objective To report the clinical features and pathological changes of two cases of adult neuronal ceroid lipofuscinosis ( ANCL ) .

方法：经口给药14d后，采用紫外比色法测定MAO-B活性，用荧光比色法测定脂褐质含量及分光光度法测定羟脯氨酸含量。

Methods The activity of MAO-B was detected by ultraviolet-spectrophotometry , the content of lipofuscin was measured by spectrofluorimetry , and the content of hydroxyproline was tested by spectrophotometry 14 days after administration of CML .

成人型与青少年型神经元蜡样质脂褐质沉积症

Adult Neuronal Ceroid Lipofuscinosis and Juvenile Neuronal Ceroid Lipofuscinosis

脑组织丙二醛含量及脑组织和肝脏脂褐质含量。

Content of MDA in brain tissue and contents of lipofuscin in cerebral and hepatic tissues .

不同类型神经元蜡样质脂褐质沉积症的超微结构特征成人型与青少年型神经元蜡样质脂褐质沉积症

THE ULTRASTRUCTURAL FEATURES OF DIFFERENT TYPE OF NEURONAL CEROID LIPOFUSCINOSIS . Adult Neuronal Ceroid Lipofuscinosis and Juvenile Neuronal Ceroid Lipofuscinosis

在其脑、心、肝组织中脂褐质含量分别增加46%、38%和16%；

The contents of lipofuscin in brain , heart and liver increased 46 % , 38 % and 16 % respectively ;

三七总皂甙、人参果总皂甙对老年大鼠心脑组织脂褐质及血清过氧化脂质含量的影响

Main saponins of notoginseng and ginseng ginsenosides decrease the contents of tissue lipofuscin and serum lipid peroxides in the old rats

结果肝细胞内出现大量脂肪滴和巨大线粒体；神经细胞线粒体受损、脂褐质增多；发现凋亡细胞。

Results Triglyceride droplets and giant mitochondrias were observed in hepatic cells , mitochondrias were damaged and lipofuscin increase in neurotic cells , observed apoptosis in both cells .

脂褐质递增.黄芪组细胞衰老过程中细胞器的变化与上述非黄芪组细胞的衰老变化规律基本相同；

The rules of changes of the organelles of the cells treated with AMB were basically the same as those of the control cells in the process of cell aging .

口服黑木耳和银耳多糖40天后，果蝇脂褐质含量有所降低，与对照组相比，分别降低12.17%和23.95%。银耳孢子多糖对果蝇寿命和脂褐质含量均无明显影响。

After administration of AA and TF for 40 days , the content of lipofuscin of Drosophila melanogaster was respectively decreased by 12.17 % and 23.95 % as compared with control .

为了探讨不同类型神经元蜡样质脂褐质沉积症的超微结构特征，对13例患者取右额叶脑组织进行了电镜检查。

To study the characteristics of each type of neuronal ceroid lipofuscinosis , 13 cases were investigated by brain biopsy with light and electron microscopes , Among these cases , two were of the infantile type ;

经口给予小鼠复合山楂、黄芪抗衰老保健饮料，能明显提高小鼠超氧化物歧化酶的比活力，降低肌脂褐质含量；果蝇寿命试验均为阳性。

When feed hawthorn and astragalus compound health beverage to mice by mouth , the specific activity of superoxide dismutase in mice was improved obviously , the content of muscle lipofuscin was decreased , and the life tests of drosophila melanogaster all were positive .