肝毒性

认为应重视肺部感染和CsA肝毒性的防治。

Attention should be paid to pulmonary infection and cyclosporin A hepatotoxicity .

美国FDA药物肝毒性监测和管理文件简析

Analysis of drug-induced hepatotoxicity and FDA white papers

CT灌注成像可以被用作无创性肝毒性检测工具。

Perfusion CT may be used as a noninvasive tool in diagnosing hepatic toxicity .

采用logistic回归分析移植术后肝脏损害和CsA肝毒性发病的危险因素。

A univariate logistic regression test was used to identify risk factors for post-transplant liver injury and CsA hepatotoxicity .

目的初步确定氟他胺（flutamide，Flu）肝毒性发生的机制。

Purpose To study the liver toxicity mechanism of flutamide in SD rats .

大鼠枯否细胞活化与TNT肝毒性的关系

The relationship between functional activation of Kupffer cells in rat liver and TNT-induced hepatotoxicity

发酵莲子乳对小鼠急性CCl4肝毒性保护作用

Protective effect of lotus-seed milk fermented product on acute CCl_4 hepatic toxicity in mice

结果TNT可加强对Kupffer细胞功能活化大鼠的肝毒性。

Results TNT could strengthen the hepatotoxicity in those rats with functional activation of Kupffer Cells .

结论TBIL可以作为肺移植术后免疫抑制药物CSA肝毒性的敏感指标；

Conclusion TBIL is the sensitivity index of hepatotoxicity of immunity inhibitor CSA after lung transplantation .

目前，HAART导致肝毒性的机理尚不清楚。

The mechanisms involved in HAART-derived hepatotoxicity are not well understood .

结论：HBV、TB合并感染时，抗TB药物的肝毒性增强，治疗过程中应及时复查肝功能。

Conclusion : Liver toxicity during anti-TB treatment was increased in patients with TB + HBV infection , and so liver disfunction should be detected in time .

普乐可复组的肝毒性和神经毒性反应发生率均比CsA组低（P<0.05）；

Incidence of hepatotoxicity and neurotoxicity in FK506 group was lower than that of CsA group ( P < 0.05 ) .

结论CsA肝毒性为肾移植术后常见并发症，FK506肝毒性明显低于CsA；

Conclusion The hepatotoxicity of cyclosporine-A is the common complication of renal transplantation , that of tacrolimus is apparently lower .

藻毒素MC由于具有肝毒性和肿癌促进作用直接影响鱼类和人畜的安全，已引起各界的广泛关注。

MC toxicity due to liver cancer has a role in promoting a direct impact on the safety of fish and livestock , which has caused widespread concern .

而CVP则以骨髓毒性和肝毒性为特征，分别为38.70%和12.90%。

The toxicities of CVP were mainly myelotoxicity ( 38 . 70 % ) and hepatotoxicity ( 12.90 % ) .

TPN溶液的肝毒性可能与酪氨酸、半胱氨酸、牛磺酸等必需氨基酸缺乏有关。

Hepatotoxicity of nutrient admixture may be related to the deficiency in essential amino acids such as tyrosine , cysteine , taurine and so on .

HAART的毒性作用之一是肝毒性，其可造成HIV患者的治疗中断、亚临床肝炎，甚至出现致死性肝衰竭。

One of the toxicities linked to the use of antiretrovirals is hepatotoxicity , which lead to treatment discontinuation , subclinical hepatitis even fatal hepatic failure in HIV-infected patients .

对APAP的肝毒性是导致药物性肝损伤的主要原因。

APAP hepatotoxicity is the leading cause of DILI .

结果说明Aza的毒性反应尤其是肝毒性仍很明显。

These findings show Aza toxic reaction , especially the liver toxicity is significant , much attention should be paid .

结论CsA+MMF+Pred、FK506+MMF+Pred是目前较为理想的免疫抑制治疗方案，低剂量CsA可减少肝毒性的发生。

Conclusion CsA + MMF + Pred and FK506 + MMF + Pred are ideal treatment after renal transplantation , and low CsA concentration can decrease the incidence of hepatic dysfunction .

目的探讨大鼠肝脏Kupffer细胞功能活化与TNT肝毒性的关系及可能机制。

Objective To explore the relationship between the functional activation of Kupffer cells in rat livers and TNT induced hepatotoxicity in order to define possible mechanism of TNT induced liver injury .

既往关于DEHP的研究主要集中在短期高剂量暴露上，发现DEHP可以诱发肝毒性、睾丸毒性、肾脏毒性、发育障碍和生殖毒性等。

Previous animal studies have demonstrated short-term exposure to high-dosage DEHP induced hepatotoxicity , testicular toxicity , renal toxicity , developmental disturbance , reproductive toxicity , and teratogenicity .

目的：观察阿魏酸钠对异烟肼（INH）和利福平（RFP）肝毒性的保护作用。

OBJECTIVE To observe the protective effect of sodium ferulate on mice hepatic injury induced by isoniazid ( INH ) and rifampicin ( RFP ) when used in combination .

死亡13例；肝毒性的发生时间为7～84d，持续时间5～96d。

Hepatotoxicity appeared between 7 and 84 d , and lasted for 5 to 96 d.

此外，N-乙酰半胱氨酸（NAC）与甘草酸（GA）与醋氨酚一起加到培养基中能显著抑制醋氨酚导致的肝毒性，进一步说明凝胶包埋培养肝细胞可以反映保肝药物的临床作用。

Moreover , addition of N-acetylcysteine or glycyrrhizic acid together with acetaminophen reduced the hepatotoxicity of acetaminophen , which illustrated the feasibility of gel entrapment culture of hepatocytes as a hepatotoxicity model to reflect the situation of a hepatoprotective drug in vivo .

结论：RPM联合CsA可有效预防移植肾急性排斥反应，并维持肾功能于良好水平，但是也可能增强CsA的肝毒性。

CONCLUSIONS : The combined therapy pf RPM plus CsA is effective in the prevention of acute renal allograft rejection , and it can maintain renal function at a good level . Nevertheless , it may increase the hepatotoxicity of CsA .

结论：NAT2基因型与异烟肼和利福平所致肝毒性关系密切，其中857位密码子点突变可能是结核患者发生肝毒性的易感基因型之一。

Conclusion : NAT2 gene mutation at codon 857 might be one of susceptible genotype in the tuberculosis patients whose hepatic functions were abnormal .

在VPA肝毒性高危因素存在时，尤其应警惕其肝毒性，然而，肝功酶谱并不是一种灵敏的用于预测VPA肝严重毒性发生的实验室指标。

We should pay more attention to VPA-induced hepatotoxicity especially in infants and those which coadministration with inducers of liver enzyme , but liver enzymes ( ALT and AST ) are not a sensitive laboratory marker to VPA-associated hepatotoxicity .

目的：药物诱发肝毒性的新认识。

Objective : To reveal the new recognition of drug-induced hepatotoxicity .

结论苦参中的肝毒性成分主要位于低极性组分中。

Conclusion : Hepatotoxic components of ESF existed in low-polarity fractions .