细胞癌变

目的：抑癌基因的失活是细胞癌变的重要机制之一，研究发现9号染色体上可能存在着与食管鳞癌发生发展密切相关的抑癌基因。

Objective : The inactivation of tumor suppressor genes ( TSG ) was one of the significant mechanisms of cell canceration .

肝细胞核因子-κB异常激活与肝细胞癌变

The association of abnormal activation of hepatocyte nuclear factor-kappa B with hepatocarcinogenesis

亚病灶肝细胞癌变的发育不良性结节的CT诊断

CT diagnosis of dysplastic nodule with subfocus of hepatocellular carcinoma

线粒体DNA与人宫颈细胞癌变的关系

Relationship between mitochondrion DNA ( mtDNA ) and carcinogenesis of human cervical cells

鼠肝细胞癌变中DNA甲基化作用的研究

Studies on DNA methylation in transformed mouse liver cells

α粒子诱发人支气管上皮细胞癌变的DNA修复基因表达谱研究

Investigation of DNA Repair Gene Expression Pattern of Radiation-Induced Malignant Transformation of Human Bronchial Epithelial Cells

鱼露促进小鼠前胃上皮细胞癌变及DNA合成的研究

Promoting effect of fish sauce on carcinogenesis and DNA synthesis in the forestomach epithelium of mice

这一结果表明DNA构象不同与人类细胞癌变相关。

These results show the view that DNA conformation variety relating with the canceration of human cell .

DNA依赖蛋白激酶在人支气管上皮细胞癌变株和肺癌组织中的异常表达

The abnormal expression of DNA-PKcs in malignant transformed cell line of human bronchial epithelial cells and lung cancers

人食管鳞状上皮细胞癌变过程中P53基因蛋白产物的表达

Expression of P53 protein in carcinogenesis of human esophageal squamous cell carcinoma

p53基因点突变与胃粘膜细胞癌变的关系

High frequency mutation of p53 gene in human gastric cancer and precancerous lesions

DNA损伤还是突变的重要原因，而严重的突变可造成细胞癌变，导致肿瘤的发生。

DNA damage was an importance factor for mutation of cells , furthermore , carcinogen can be caused by severe mutation .

这些提示乙肝病毒在肝细胞癌变过程中，可能是通过影响DNA损伤修复来起作用的，DNA修复基因在肝细胞肝癌的发生过程中起着重要作用。

These suggest that HBV may induce HCC by inhabiting the DNA repair system . The DNA repair genes play a import role in the pathogenesis of HCC .

MDS骨髓细胞癌变的主要机制

Main mechanism of malignant transformation of MDS into leukemia

Rb基因产物在大鼠肝细胞癌变过程中的异常表达及意义

The Abnormal Expression of Rb Gene Product in the Hepatocellular Carcinogenesis of Rats and its Significance

目的研究亚病灶肝细胞癌变的发育不良性结节（DNSFHCC）的CT表现和诊断。

Objective To evaluate the CT findings and diagnosis of the dysplastic nodule with subfocus of hepatocellular carcinoma ( DN-SF-HCC ) .

膜联蛋白A5与宫颈黏膜上皮细胞癌变的关系

Relationship between annexin A5 and carcinogenesis of uterine cervical cells

肝细胞癌变后缺氧程度减轻。根据AMI的程度可判断预后。

Hypoxia was attenuated after transformation from cirrhosis to HCC . The extent of AMI is helpful to judge the prognosis .

突变型p53基因的编码蛋白不但丧失上述功能，甚至出现了促使细胞癌变的作用。

The protein ( P53 ) encoded by mutant p53 gene ( mtp53 ) not only losses these functions , but also make cell malignant transformation .

结论GMA能与DNA形成加合物，其在诱导基因突变致细胞癌变的过程中可能起重要的作用。

Conclusion GMA could bind with DNA to form adducts that may play an important role in mutagenesis and carcinogenesis induced by this chemical .

目的：研究p53基因点突变在食管癌及癌前病变粘膜细胞癌变过程中的变异作用及定量分析，对病人预后的关系。

Objective : To investigate the variation action of p53 point mutation in esophagus carcinoma , precancerosis and the p53 quantitative analysis relationship with patient 's prognosis .

LSA、ADA在鼠肝细胞癌变过程中的表达与动态改变

Expression and Alterations of Lipid Associated Sialic Acid and Adenosine Deaminase during the Development of Rat Hepatoma

子宫颈上皮细胞癌变中树突状细胞分布、TNF-α、c-myc的表达及其临床意义

The expression and clinic implication of dendritic cells , TNF - α and c-myc in the carcinogenesis of uterine cervical epithelial tissue

目的：研究端粒DNA长度、hTERT蛋白定量表达与食管上皮细胞癌变的关系。

Objective : To investigate the correlations of telomere length and expression level of human telomerase reverse transcriptase ( hTERT ) protein to the carcinogenesis of esophageal epithelium .

食管癌和不典型增生，与正常粘膜组织比较，乳酸脱氢酶活性增加，P＜0.05。结论①p53基因点突变是食管粘膜细胞癌变过程中多因素作用的结果。

Compared esophagus carcinoma and dysplasia with normal mucosa tissue , the activity of LDH increased , P < 0.05.Conclusion ① p53 gene point mutation was the effect of multiple factors in the course of canceration of esophagus mucosa cells .

通过体外对Nlp功能研究显示它可使细胞癌变，提示这是一种原癌蛋白。

In vitro analysis of the function of Nlp indicated that it conferred on cells tumorigenic properties , suggesting that it was an oncogenic protein .

目的探讨由人乙型肝炎病毒（HBV）和黄曲霉毒索B1（AFB1）诱发的树鼩肝细胞癌变过程，p53基因的表达及变化。

Objective To detect the expression and variation of p53 gene during tree shrews ' hepatocarcinogenesis induced by hepatitis B virus ( HBV ) and aflatoxin Bl ( AFB1 ) .

胃癌腺苷脱氨酶的酶学性质研究LSA、ADA在鼠肝细胞癌变过程中的表达与动态改变

A Study on Enzymatic Properties of Adenosine Deaminase from Human Stomach Carcinoma Expression and Alterations of Lipid Associated Sialic Acid and Adenosine Deaminase during the Development of Rat Hepatoma

结论：蛙皮素可与化学致癌剂协同促进正常上皮细胞癌变，其机制可能与cyClinD1的过表达有关。

Conclusions : Bombesin seems to exert a synergistic effect with chemical carcinogen in promoting malignant transformation of normal epithelial cells , which may be related to the increased cyclin D1 expression .

目的观察腺苷脱氨酶（AdenosineDeaminase，ADA）和鸟嘌呤酶（guanase，GUA）在肝细胞癌变过程中的表达与动态变化。

Objective To observe the expression and kinetic alteration of adenosine deaminase ( ADA ) and guanase ( GUA ) during the carcinogensis of rat livers .