线粒体呼吸链

Q是线粒体呼吸链的电子载体，同时也是一种脂溶性的抗氧化剂。

Q is an electron carrier in the mitochondrial respiratory chain and is a type of lipid-soluble antioxidant .

帕金森病（PD）的发病机制与线粒体呼吸链复合物I（complexI）活性降低以及氧化应激损伤密切相关。

The inhibition of mitochondrial respiratory chain complex I and oxidative damage have been implicated in the pathogenesis of Parkinson 's disease ( PD ) .

用酶动力学和聚合酶链式反应（PCR）对大鼠心肌线粒体呼吸链酶复合物Ⅰ、Ⅳ活性的变化及线粒体DNA的缺失进行测定。

Animal experiments with enzyme kinetics and PCR ( polymerase chain reaction ) technique were conducted .

辅酶Q（10）和复方丹参对心肌线粒体呼吸链的保护作用

Protective effect of compound radix salviae miltiorrhizae and ubiquinone _ ( 10 ) for respiration chain in myocardial mitochondria

结论线粒体呼吸链中cytb、ATPase6在肺发育中起重要作用。

Conclusions Cyt b and ATPase 6 of mitochondrial respiration chain have vital effects on lung development .

HIF-1与线粒体呼吸链的关系及对细胞糖代谢的影响

Effects of HIF-1 on the Glut-1 and GK and Its Regulating by Mitochondrion Respiratory Chain

结论（1）GSH能减轻黑质区氧化应激损伤，并对线粒体呼吸链具有一定保护作用；

Conclusions GSH could decrease the nigral oxidative stress , and exert some protective effect on mitocondrial respiration-chain .

结果T2毒素可使大鼠心肌组织中ATP含量、线粒体呼吸链呼吸酶、细胞色素氧化酶活力以及ATP酶活力下降。

Results T 2 toxin could reduce the content of ATP in myocardium and decrease the activity of Cyt-c and ATPase .

结论：牛磺酸抑制Hcy刺激的线粒体呼吸链电子漏增加及氧自由基生成。

CONCLUSIONS : Taurine inhibited electronic leakage and oxygen free radical production induced by homocysteine in electron transport chain .

淫羊藿还可提高脑线粒体呼吸链复合酶Ⅳ活力和骨骼肌线粒体ATP的合成。

Treatment of Herba Epimedii alone also increased the activity of mitochondrial respiratory chain enzyme complexes ⅳ in brain and the rate of muscular ATP synthesis .

线粒体呼吸链酶复合体活性、线粒体及肌肉组织中抗氧化物酶活性、丙二醛（MDA）含量及蛋白质羰基含量均用紫外分光光度计测定。

Activities of mitochondrial respiratory chain complexes , antioxidative enzyme activities in mitochondria and skeletal muscle , and content of MDA and protein carbonyl was measured by UV spectrophotometry .

高糖对INS-1细胞线粒体呼吸链功能的影响

High glucose impairs mitochondrial respiratory chain function in pancreatic β cells

CLA对2型糖尿病大鼠肝脏线粒体呼吸链酶活性及氧化应激的影响

Effect of conjugated linoleic acids on hepatic oxidative stress and hepatic mitochondrial respiratory chain enzyme activities in type 2 diabetic rats

生理状态下，线粒体呼吸链是ROS主要来源，其中不多于线粒体总氧耗的5%用于产生ROS。

Under physiological conditions mitochondrial electron transport chain is a major sourse of ROS and represents less than 5 % of total mitochondrial oxygen consumption .

目的研究丹参对兔重症急性胰腺炎（SAP）肠粘膜上皮细胞线粒体呼吸链功能及氧自由基的影响。

Objective : To explore the effect on Dan shen root to mitochondrial electron transport chain and free radical in intestinal mucosa epithelial cells of rabbits with severe acute pancreatitis .

交替氧化酶（alternativeoxidase，AOX）是植物线粒体呼吸链中抗氰呼吸途径（cyanide-resistantrespirationpathway）的末端氧化酶，它广泛存在于高等植物及部分真菌和藻类中。

Alternative oxidase is the terminal oxidase in the cyanide-resistant respiration pathway in plant mitochondria , which widely existing in higher plants and parts of fungi and algae .

植物细胞内的AsA合成受线粒体呼吸链调控，但详细的调控机理仍不清楚。

Some refernces reported that AsA biosynthesis in plants could be modulated by mitochondrial respiratory chains . But the deep modulating mechanisms are still not quite clear .

ROS的毒性作用包括脂质过氧化物（Lipidperoxidation）的形成，线粒体呼吸链酶的抑制，膜Na~+-K~+-ATPase的抑制，以及其它蛋白的氧化修饰作用。

These include initiation of lipid peroxidation , inhibition of mitochondrial respiratory chain enzymes , inactivation of membrane Na + - K + - ATPase activity , and other oxidative modifications of proteins .

由清华大学-中科院生物物理所结构生物学联合研究小组完成的线粒体呼吸链膜蛋白复合物II的晶体结构研究成果以Article的方式发表在2005年7月1日出版的Cell上。

An article entitled Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II was published in the July 1st , 2005 issue of the journal Cell . This research work was accomplished by the Tsinghua - Institute of Biophysics Joint Research Group for Structural Biology .

辅酶Q10是细胞线粒体呼吸链重要成员之一，是细胞自身产生的天然抗氧化剂和细胞代谢的激活剂。

Coenzyme Q_10 is an important member of cell mitochondrial respiratory chain . It is a natural antioxidant and cell metabolism activator .

高糖和游离脂肪酸诱导胰岛INS-1细胞线粒体呼吸链改变的研究

Role of mitochondrial respiratory chain in the B-cell defects induced by chronic exposure to high glucose and free fatty acids

细胞内线粒体呼吸链过程中的电子漏和神经细胞代谢的酶类如单胺氧化酶（MAO）等可产生活性氧物质（ROS）如H2O2等。

Reactive oxygen species ( ROS ), such as H2O2 , can be produced by enzymes involved in electron leakage of respiration chain in mitochondria , and by neurochemical enzymes such as monoamine oxidase in neural cells .

该家族首个成员在酿酒酵母中分离出来，因其能够抑制细胞色素bmRNA翻译的缺陷以及维持线粒体呼吸链bcl复合体的活性而得名。

The prototype of this family was isolated from Saccharomyces cerevisiae and was named due to its role in the suppression of a defect in cytochrome b mRNA translation and maintainance of the activity of bcl complex in the mitochondrial respiratory chain .

目的：观察共轭亚油酸（CLA）对2型糖尿病（DM2）大鼠肝脏线粒体呼吸链酶活性及肝内氧化应激（OS）的影响。

AIM : To observe the effect of conjugated linoleic acids on hepatic oxidative stress and enzyme activities of hepatic mitochondrial respiratory chain in type 2 diabetic ( DM2 ) rats .

结论：CLA通过抑制氧化应激增强大鼠肝脏线粒体呼吸链酶活性改善了DM大鼠肝脏的能量代谢障碍，对DM引起的氧化损伤有保护作用。

CONCLUSION : CLA ameliorates the energy metabolism impairment of DM liver by suppressing the oxidative stress and improving the activity of enzymes in mitochondrial respiratory chain , and CLA has effective protection from the oxidative injury induced by DM .

方法：以健康雄性Wister大鼠为实验对象，随机分为安静对照组、大强度运动组和中等强度运动组，分光光度法测定线粒体呼吸链酶复合体（Ⅰ~Ⅲ）活性。

Twenty-one healthy male Wister rats were randomly divided into control group , high-intensity exercise group and middle-intensity exercise group . Spectrophotometric analysis was applied to evaluate RCC activities .

方法用线粒体呼吸链复合体Ⅱ/Ⅲ抑制剂&3-硝基丙酸（3nitropropionicacid，3NPA）20mg/kg对SD大鼠隔日腹腔注射连续造模20d，建立HD大鼠模型。

Methods The SD rat model of Huntington 's disease was established by peritoneal injection of 3 nitropropionic acid , the mitochondrial respiratory chain complex ⅱ / ⅲ inhibitor , 20 mg / kg , once every other day , successively for 20 days .

方法：测定通过口服途径亚慢性暴露于百草枯、MPTP或等量生理盐水的小鼠脑内线粒体呼吸链中复合酶Ⅰ、Ⅱ、Ⅳ及柠檬酸合成酶的活性。

Methods : Activities of complex ⅰ, complex ⅱ, complex ⅳ and citrate synthase were measured after mice exposed to paraquat or MPTP or the same amount normal saline administered orally every day for 2 months .

其作用机制可能涉及SOD2表达降低及出现功能异常的SOD1表达；SOD表达和功能异常导致氧化应激平衡失调，后者损伤线粒体呼吸链复合体，引发神经元退行性变。

Its mechanism may be related to the down-regulation of SOD2 and over-expression of abnormal SOD1 . The decline of SOD activity can lead to the disruption of oxidative stress balance , which inhibits the activity of mitochondrial respiratory chain complex and causes neurodegeneration .

目的研究氧应激对大鼠心肌线粒体呼吸链酶活性的影响及中药复方益心康胶囊（H303）含药血清对损伤的保护作用。

Objective The effect of oxygen stress on the enzyme activity of rat myocardial mitochondria respiratory chain ( MRC ) and the protective effect of drug-containing serum of Yi-Xin-Kang capsule ( H303 ) .