端粒

即便研究人员们考虑了其它能影响端粒长度的因素（比如她们的实际年龄、身体质量指数和吸烟习惯），这些发现依旧站得住脚。

The findings held even after the researchers took into account other factors that could affect telomere length , including the women 's chronological age , body mass index and smoking habits .

端粒DNA在法医学年龄推断中的应用

The Application of Telomere DNA in Age Estimation of Forensic Medicine

研究人员们观察了这些女性细胞内的遗传物质，尤其是她们端粒的长度。

The researchers looked at the genetic2 material inside the women 's cells , specifically the length of their telomeres .

人们在变老的过程中，端粒也会自然缩短，但这个结构在每个人身上变短的速度均不同。

Telomeres naturally shorten as people age , but the structures don 't shorten at the same rate in every person .

一个人的端粒越长，他们的细胞理论上能够分裂的次数就越多。

The longer a person 's telomeres are , the more times their cells could hypothetically still divide , research has shown .

她说，还需要进一步的追踪研究来确定女性的端粒在生孩子之前、怀孕期间和产后的长度。

More studies are needed that follow women over time and measure the length of their telomeres before , during and after pregnancy , she said .

研究人员们无法确定生孩子与更短的端粒长度之间，哪一个先出现。波莱克说，有可能出于某些未知的原因，端粒更短的女性比端粒更长的女性更有可能生孩子。

It 's also possible that for some yet-unknown reason , women with shorter telomeres are more likely than women with longer ones to have children , Pollack said .

并且，端粒也被科学家们视为生理年龄的标记，即一个人的细胞年龄，而不是他们的实际年龄。

Thus , telomeres are considered a marker of biological age — that is , the age of a person 's cells , rather than the individual 's chronological4 age .

在研究中，至少生过一个孩子的女性端粒长度平均比那些未生产过的女性短百分之四。

Women in the survey who said they 'd given birth to at least one child had telomeres that were about 4 percent shorter , on average , than those of women who 'd never given birth .

这些发现表明生产史可能与更短的端粒之间存在着联系。该研究的概述在美国公共卫生协会于丹佛市举办的会议上发布。

These findings suggest that a " history of live birth may be associated with shorter telomeres , " the researchers wrote in their abstract , which was presented at the meeting of the American Public Health Association in Denver .

该研究并未探究这一联系背后的原因，但有猜测认为生孩子会增加女性的压力，而高压与更短的端粒有关。

The study was not designed to determine the reason behind the link , the researchers said . But one hypothesis is that having children increases stress levels , and high stress has been linked with shorter telomeres , the scientists said .

维生素C具有一定的抗氧化作用，它能减低过氧化损伤，从而减缓端粒缩短的速率。

C can slow the rate of telomere shortening .

催化信标检测端粒DNA序列的初步研究

Primary Study on Spectrophotometric Detection of Telomeric DNA with Catalytic Beacons

线粒体DNA和端粒与年龄相关性的研究进展

The development of research on correlation of mitochondrial DNA and telomere with individual age

小鼠肺组织细胞及胚肺细胞的DNA含量、凋亡及细胞周期，脾淋巴细胞转化率，血液及肺组织的端粒长度及小鼠全基因组的表达谱变化。

ELC DNA content , apoptosis and cell cycle of mouse lung cell and ELC ;

应用Southern杂交技术检测端粒长度的变化。

Southern hybridizing were applied to determine telomere length .

推测，可能存在端粒愈短，DNA扩增愈活跃。

It is speculated that the shorter the telomere length the more amplificative activity the DNA .

RNA干扰抑制端粒酶对受照后端粒长度的影响

Effect of RNAi inhibiting telomerase on telomere lengths after irradiation

端粒蛋白包括端粒双链DNA结合蛋白、端粒单链DNA结合蛋白、其它端粒相关蛋白。

Telomeric proteins is composed of double DNA binding protein , single DNA binding protein and telomeric associated proteins .

皮肤光老化机制研究&紫外线照射对成纤维细胞染色体端粒DNA复制的影响

Investigation of Skin Photoaging Mechanisms-Influences of Ultraviolet Irradiation on the Telomere Length of Chromosome in Primary Cultured Human Fibroblast

端粒重复因子2与p53的体外结合

In vitro binding of p53 and telomeric repeat factor 2

P53与端粒重复序列结合蛋白质1的体外相互作用

The molecular interaction between P53 and telomeric repeat binding protein 1 in vitro

大量研究已经证明各种因素造成端粒功能障碍也是通过诱导DNA损伤反应途径来抑制肿瘤生长。

Compelling evidences have demonstrated that induction of telomere dysfunction suppress cancer cell growth via activating the cellular DNA damage machinery .

Hela细胞端粒DNA断裂损伤

Strand breaks in telomeres in Hela cells

如果发生在端粒DNA上，则会影响端粒DNA的生理功能；

If DNA damages take place on the single strand part of telomere DNA , the physiological function of it maybe changed .

用端粒重复扩增（TRAP）PCR法测定细胞的端粒酶活性。

A PCR based telomeric repeat amplification protocol ( TRAP ) was used for assaying telomerase activity .

现就DNA损伤检控系统在维持端粒稳定中的作用及其对功能缺陷端粒的应答作一简要综述。

Here , we review recent studies defining the roles of DNA damage checkpoint in telomere maintenance and in response to telomere dysfunction .

你可能对基因的组成部分不太了解，所以我简单介绍一下，染色体端粒是DNA链条末端的小帽子。

If you are unfamiliar with the componentry of your genes , telomeres are the tiny caps on the ends of DNA strands .

用端粒重复序列扩增法（TRAP）测定上述组织标本中的端粒酶活性。

Telomerase activity was examined in these samples with telomeric repeat amplification protocol ( TRAP ) .

端粒重复扩增程序（TRAP）的改进和应用以及端粒酶酶学性质研究

Improvement & Application of Telomeric Repeat Amplification Protocol ( TRAP ) and Research on Telomerase characteristic