神经元变性

Cdk4/cyClinD1通路异常参与C型Niemann-Pic病小鼠神经元变性

Activation of Cdk4 / cyclin D1 Pathway Participates in the Neuronal Degeneration of Murine Niemann-Pick Disease Type C

目的：阐明陈旧性脑损伤继发神经元变性的MRI表现及其临床意义。

Objective : To explain MRI findings of secondary neuronal degeneration due to old brain injury and to assess their clinical significance .

帕金森氏病（PD）是一种神经退行性疾病，其特征为黑质的多巴胺能神经元变性。

Parkinson 's disease ( PD ) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra .

神经退行性疾病（Degenerativediseasesofthecentralnervoussystem，ND）是一组以原发性神经元变性为基础的慢性进行性神经系统疾病。

Degenerative diseases of the central nervous system ( ND ) are a group of chronic and progressive nervous systemic diseases based on the primary neuronal degeneration .

结论iNOS上调可能是LPS诱导DA能神经元变性机制中重要的因素之一。

Conclusion Up-regulation of iNOS may be one of the crucial mechanisms in LPS-induced degeneration of DA neurons .

βA4表达与神经元变性、缺失有关。

β A 4 is related to neuron degeneration and loss .

结论：LPS能诱导黑质DA能神经元变性，呈剂量和时间依赖性。

Conclusion : LPS could induce the degeneration of DA neurons in the SN in a dosage and time dependent manner .

目的探讨脂多糖（LPS）诱导小胶质细胞（Mic）激活规律与黑质多巴胺（DA）能神经元变性的关系。

Objective To explore the relationship between the activities of microglia induced by LPS and the degeneration of dopaminergic neurons .

NGF预防大鼠额叶皮质损伤后基底前脑胆碱能神经元变性

Retrograde Degeneration of Cholinergic Neurons of Basal Forebrain Induced by Frontal Cortexes Injuries is Prevented by NGF in Rats

上述结果表明：外周给予葡聚糖铁可造成脑内SN铁聚积，并可导致DA能神经元变性死亡。

The above results strongly suggest that high iron in brain may be involved in the process of death of DA neurons .

研究已发现，胎儿长期暴露于高浓度GC可选择性损伤海马，导致神经元变性坏死。

It has been demonstrated that chronic exposure of fetus to high concentration GC selectively injured hippocampus and lead to degeneration and necrosis of neuron .

治疗组与DAI模型组相比，伤后脑组织肿胀明显较轻，神经元变性也少。

Treatment group compare with the DAI model , swelling of brain tissue injury is mild , neuronal degeneration is also less .

目的为了观察神经生长因子（NGF）对大鼠额叶皮质损伤后基底前脑胆碱能神经元变性的预防效果。

Objective To observe the preventive effects of NGF on the retrograde degeneration in cholinergic neurons of basal forebrain in rats with frontal cortexes injuries .

结果EMP辐射引起以神经元变性和固缩为主的组织病理学改变，并导致神经细胞超微结构损伤。

Results Degeneration and consolidation of neurons were observed in hippocampal tissue after EMP radiation , ultrastructural injury could be seen as well .

C型Niemann-Pick病小鼠P27~（kipl）表达异常与神经元变性和星形胶质细胞增生

Deregulation of P27 ~ ( kipl ) is related with neuronal degeneration and astrocytosis in a mouse model of Niemann-Pick disease type C

DAI模型组的大鼠大脑皮层、脑干等部位可见局灶性点状出血，大脑皮层脑组织水肿，神经元变性萎缩。

The cerebral cortex , brain stem and other parts of DAI model group can be seen in focal spotting bleeding , cortical swelling , degeneration of neurons to shrink .

神经退行性疾病（neurodegenerativedisease）是指中枢神经系统组织非正常退变引起的功能缺陷与衰退的一类疾病，病理上表现为脑和脊髓发生神经元变性、丢失。

Neurodegenerative disease is a kind of disease which is caused by the abnormally degeneration of the central nervous system organization . The symptoms of the neurodegenerative disease are the degeneration and loss of neurons .

病理改变为中脑黑质纹状体区多巴胺能神经元变性凋亡和lewy小体形成为特征。

Pathological changes are dopaminergic neurons degeneration and apoptosis of the nigrostriatal area in the midbrain and the formation of lewy small body .

结果缺血再灌注后12小时治疗组较缺血再灌注组海马CA1区神经元变性、坏死程度明显减轻，随再灌注时间的推移两组变性、坏死及形态不规则的神经元均逐渐增多；

Results Degeneration and necrosis of hippocampal neurons significantly relieved in 12 hours after reperfusion in treatment group compared with ischemia reperfusion group .

而且，由FJC揭示的神经元变性（包括急性和迟发性神经元损伤）是时间依赖性的。

Moreover , cellular degeneration including acute and delayed neuronal death revealed by FJC stain was time-dependent .

肌萎缩侧索硬化症（amyotrophiclateralsclerosis，ALS）是一种慢性进行性神经系统变性病，以上、下运动神经元变性为特征。

A Study of Transcranial Magnetic Stimulation Motor Evoked Potentials on Amyotrophic Lateral SclerosisBackground : Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disease affecting both lower and upper motor neurons ( UMN ) .

结论NGF对双侧额叶皮质损伤大鼠的学习、记忆机能障碍及基底前脑胆碱能神经元变性有预防效果。

Conclusion NGF treatment could not only prevented from occurrence of learning or memory disturbance , but also from retrograde degeneration of the AChE-rich neurons of the basal forebrain in the rats with bilateral frontal cortexes injuries .

应用弥散加权MRI定量评估多系统萎缩症的脑干情况目的探讨橄榄桥小脑萎缩（OPCA）的本质及与其他神经元变性病的关系。

Objective In order to explore the entity of olivopontocerebellar atrophy ( OPCA ), the relationship of OPCA with progressive neurodegenerative diseases and the application of the term multiple system atrophy ( MSA ) clinically .

结论提示IGF-1系统参与了MND的发病机理，神经营养支持的缺乏是导致脊髓运动神经元变性的原因之一。

Conclusion IGF 1 system was involved in the pathogenic mechanism of MND , the lack of neurotrophic support might be one of causes in leading to degeneration of spinal motor neurons .

目的观察βA4在弥漫性Lewy体病（DLBD）脑组织中的表达，探讨βA4表达与神经元变性、缺失的关系。

Objective To observe β A 4 expression in diffuse Lewy body disease ( DLBD ) and investigate the relationship between β A 4 expression on neuron degeneration and loss .

PD的病理特征是患者黑质致密体部位的多巴胺神经元变性，纹状体内多巴胺能神经中递质含量显著减少，导致黑质纹状体多巴胺神经功能低下而胆碱能神经功能相对占优势，从而产生运动障碍。

The characteristic pathogenesis of PD is degeneration of dopaminergic neurons in nigra zona compacta and decrease of the neuron-transmitter dopamine content in striatum , which lead to dysfunction of the dopaminergic neurons and relative domination of cholinergic function . All the above alterations finally result in development of dyskinesis .

脊髓小脑共济失调（SCAs）是一组具有多变的小脑、脊髓小脑束和脑干神经元变性的异质性神经病。

Spinocerebellar ataxias ( SCAs ) are a heterogeneous group of neurological disorders characterized by variable degrees of degeneration of the cerebellum , spinocerebellar tracts , and brain stem neurons .

结论MSA早期小脑的病变是以轴索病变为主而神经元变性则较轻，并且在齿状核出现的PV（+）神经元可能是一种细胞保护性反应。

Conclusion In the early stage , MSA is shown the degeneration of neuron is mild , and the lesion of axon is the main pathological changes . The PV ( + ) neuron in the dentate nucleus may due to the cell protective reaction .

脑出血后迟发性神经元变性的发生及铁离子的作用

Delayed neuronal degeneration after intracerebral hemorrhage : the role of iron

普鲁卡因阻滞对神经断伤所致神经元变性的影响

The Effect of Procaine Block on Degeneration of Neurons Caused by Axon Transection