碱基插入

9例为点突变，其中错义突变4例、无义突变2例、同义突变3例，其余2例为碱基插入和缺失导致的移码突变。

There were 9 point mutations , including 4 missense mutations , 2 nonsense mutations , 3 silent mutations . The other 2 cases were frameshift mutations due to base insertion and deletion .

结果7例亚急性重型肝炎病人的HBV分离株CP区分别有2～12个替代变异，1例病人有11bp的碱基插入。

Results There were 2 12 nucleotide substitutions in CP region in the 7 subacute fulminant hepatitis patients studied . An 11 bp nucleotides insertion was found in one patient .

该引物还在301位点上均有T碱基插入现象，引起了编码氨基酸的改变，由原来的CCT脯氨酸→TCC丝氨酸。

The primer also has 301 points on the T insertion phenomenon , caused changes in amino acid from the CCT proline → TCC serine .

本研究同时提出了水稻稻米糊化温度调控的分子遗传假说，认为基因编码区内碱基插入、缺失或替换可能是GT改变的遗传基础。

A hypothesis for molecular mechanism for GT variation of rice is presented , that is DNA insertion , deletion or base substitution in coding sequence of alk contributes to GT variation of rice .

阿尔茨海默病患者神经型尼古丁受体α7亚单位基因多态性：发现一个新的GTG三碱基插入突变

Subunit gene polymorphisms of neural nicotinic receptor alpha 7 in patients with Alzheimer disease : A new GTG tribasic insertion mutation

有2处较大的碱基插入/缺失突变。

There existed much greater mutation of insertion / absence at 2 locations .

在获得的426bp序列中，A+T含量约占65.0%，有4个多态位点，无任何碱基插入和缺失。

Of the 426 bp mitochondrial cytochrome b DNA sequences obtained , A % + T % was about 65.0 % , four nucleotide sites were substituted , and no base composition of the sequences was inserted and lost .

与日本海和鄂霍茨克海斑海豹相比，辽东湾斑海豹线粒体DNA的16296位点有1个碱基的插入，这个插入可以区分这几个海区斑海豹种群。

Compared with spotted seals along Sea of Japan and Sea of Okhotsk , Spotted seals of Liaodong Guif had one base insertion at site 16296 of mtDNA , which prove to be marker between these two populations .

1例85密码子第2、3碱基之间插入A，同时86密码子第2碱基缺失，即GCA→GA导致无义突变。

Case had 1 base pair insertion TT → TAT in 85 codon and 1 base pair deletion GCA → GA , which may result in nonsense mutation .

结果表明，在COI基因片段中，存在碱基的插入或缺失。

Results of the mitochondrial COI gene sequence revealed that deletion / insertion were detected among COI gene fragments .

与GenBank中另外2种小沙丁鱼的同源序列比对，去除部分端部序列后得到599bp同源序列，其中包括445个简约信息位点，154个变异位点，没有发现碱基的插入缺失。

A total sequence of 599 nucleotide base pair was obtained by alignment with homologous sequences of another two Sardinella species in GenBank . There were 445 parsimony-informative sites and 154 variation sites , but no insertion / deletions were observed .

侧翼序列个别碱基的插入或缺失；

Having deletion or insertion of one or two base ( s ) in flanking sequence ;

深入分析后发现导致bccp2、bccp3编码蛋白长度缩短的根源在于其内含子3与4之间存在一个由碱基A插入造成的移码突变。

Further analysis revealed that the shortened protein of the two bccp isoforms is arisen from a frame-shift mutation which is caused by an adenine insertion between intron 3 and intron 4 in the gene .

包括8个点突变（6个错义突变，1个静息突变和1个内含子突变）和1个碱基对插入突变（在下游产生终止信号）。

All of them have been characterized to represent DNA alterations by sequencing , including 8 point mutations ( 6 missence , 1 silent mutation and 1 in intron ) and a 1 base pair insertion ( introducing a stop codon downstream ) .

多数人对于癌症的理解为，这是一种由于基因变异导致体细胞失去正常调控而引起的疾病。这种变异包括碱基替代、插入和切除，以及由于DNA链的断裂造成的序列重组等等。

Most people thought genetic mutations include base substitution , insertion as well as DNA strand breaks cause cells loss of regulation , thus induce cancer .

结果：28例喉癌中有50%在p53基因的第7～8外显子有突变，其中4例行DNA序列分析表明均有碱基替换、插入或丢失；

Results : p53 gene mutation existed in 50 % cases of laryngeal cancer and DNA sequencing showed base substitution , insertion or deletion in 4 cases ;

测序结果显示，该两个片段的大小分别为251bp和245bp，并且两个片段的差异在于两个TCT重复序列（6个碱基）的插入或缺失。

Fragements sequencing of the codominant AFLP marker indicated that their length were 251 bp and 245 bp , respectively . The difference of the two fragements lied in the insert-deletion of two TCT repeat sequences .

两分离株的F基因都没有碱基的缺失和插入，但有多处点突变，分散存在。

None of the F genes of the isolated NDV virulent strains suffered any base deletion and insertion , but there are mutations in many points scattering about .

所有移码突变表现为1～2个碱基的缺失或插入，大多（7/9）发生在简单核苷酸重复序列，特别是单腺苷酸重复序列（A）n（5/9）。

All of frameshift mutations were deletion or insertion of 1 2 bp and most of them ( 7 / 9 ) happened at simple nucleotide repeat sequences , particularly within ( A ) n tracts ( 5 / 9 ) .

两毒株都存在碱基的突变、插入和缺失。

Insertions , mutations and deletions were found in M gene of the two isolate .

其中也包含有一个位点连续三个碱基的缺失突变和一个位点一个碱基的插入突变。

The eminent differences were also a continuous delete mutation of three nucleotides at one site and one insert mutation of a single nucleotide at another site in Yunnan yak ′ s genome .

通过Mega软件对所得线粒体控制区序列的片段进行比较，共检测出114个碱基存在变异，其中包括84个简约信息位点，5个碱基存在插入/缺失；

And then , comparing the control region fragments with each other by Mega software , 114 sites were variable among all the partial mitochondrial control region sequences including 84 parsimonious message sites and five deletion / insertion sites .