硬皮病

硬皮病浸润肺的CT表现

CT Manifestation of Lung Infiltrated by Scleroderma

硬皮病的胸部高分辨率CT表现

High resolution CT features of scleroderma

V型胶原导致的硬皮病样重塑

Scleroderma-like remodeling induced by type V collagen

目的观察VEGF对硬皮病小鼠模型毛发生长的作用。

Objective To study the effect of VEGF on the hair growth in mice with scleroderma .

局限性和系统性硬皮病皮损的组织病理特征及bcl-2蛋白表达

Histopathologic characteristics and expression of bcl 2 protein in skin lesions of localized and systemic scleroderma patients

结论VEGF对硬皮病小鼠模型毛囊的再生有明显的促进作用。

Conclusion VEGF can significantly promote the growth and regeneration of the hair follicles in the mice with scleroderma .

系统性红斑狼疮、系统性硬皮病和皮肌炎患者血清sIL-2R和IL-6含量

Serum sIL-2R and IL-6 in patients with systemic lupus erythematosus , systemic scleroderma and dermatomyositis

“如果是死于硬皮病相关疾病，那么一半的死因是肺部并发症，”Dr。

" If you die of a scleroderma-related problem , half of those deaths are from lung disease ," said Dr.

系统性硬皮病肺纤维化HRCT表现与病程的关系

Pulmonary Fibrosis in Systemic Sclerosis : Correlation between HRCT Findings and Disease Duration

结论硬皮病成纤维细胞Ⅰ型胶原mRNA表达增多，这种表达增多与成纤维细胞自身合成TGF-β1的水平可能无关。

Conclusion The type ⅰ collagen mRNA expression was elevated in SSc fibroblasts , which may be uncorrelated with the TGF - β 1 .

原位RT-PCR法检测硬皮病皮损中TGF-β1、β2mRNA的表达

The expression of TGF - β 1 and β 2 mRNA in lesions of scleroderma by using in situ RT-PCR technique

方法对16例硬皮病病人行HRCT扫描，并对其表现进行分析。

Methods Sixteen cases of scleroderma were examined with HRCT , and the HRCT features were analyzed .

紫外线A1诱导局限性硬皮病中与临床改善相关的人类β-防御素、白介素-6及白介素-8的表达下调

Ultraviolet A1-induced downregulation of human β - defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma

结论：应用CT及HRCT检查，可以帮助确定硬皮病浸润肺的程度、分期并能估计预后。

Conclusion : CT and HRCT can help to determine the stages , the infiltrating degree , and to estimate the prognosis in patients with scleroderma .

硬皮病和银屑病作为皮肤科的两大常见疾病，与整合素以及ECM的关系也早有研究。

Scleroderma and psoriasis are two common skin diseases , and their relation with integrin and ECM have been studied for years .

目的：探讨系统性硬皮病（SSc）肺纤维化的高分辨力CT（HRCT）表现与临床病程的关系。

Purpose : To evaluate the correlation between HRCT findings of pulmonary fibrosis and disease duration in patients with systemic sclerosis ( SSc ) .

冷诱导心肌SPECT与UCG对诊断系统性硬皮病心肌损害的对比研究

Comparison of SPECT myocardial scans and echocardiography by cold-induced in detecting myocardial lesions of patients with systemic sclerosis

系统性硬皮病患者血清ENA多肽抗体与临床的关系

Clinical associations based on serum anti-ENA polypeptide antibodies in patients with systemic scleroderma

9例（56.3%）有食管扩张改变。结论HRCT可以显示硬皮病的细微病变，在硬皮病的诊断和治疗中具有重要价值。

Conclusion HRCT can show the delicate metastasis of scleroderma , it plays an important role in the diagnosis and treatment of scleroderma .

相比而言，继发雷诺现象指存在合并某相关疾病如SLE和硬皮病的病症。

By comparison , secondary RP refers to the presence of the disorder in association with a related illness , such as systemic lupus erythematosus and scleroderma .

目的：研究赤芍和茜草水提取物对系统性硬皮病成纤维细胞增殖和I、Ⅲ型前胶原mRNA合成的影响。

Objective : To study effects of the aqueous extracts of Red Peony Root ( RPR ) and India Madder Root ( IMR ) on proliferation and procollagen mRNA synthesis of skin fibroblasts from systemic sclerosis patients .

硬皮病小鼠皮损TGF-β1I，III型胶原含量及其相关性分析

The Content And Correlation of Transforming Growth Factor - β _1 and Collagen Type I , III in the Mouse Model of Sclerotic Skin

方法运用硫代修饰的整合素反义寡核苷酸阻断硬皮病成纤维细胞表面相应整合素亚基的表达，RTPCR检测整合素表达抑制后硬皮病成纤维细胞原胶原mRNA量的变化。

Methods Phosphorothioate modified antisense oligonucleotides were used to interfere with the expression of integrin α 5 or β 1 subunit on scleroderma fibroblasts respectively , then the changes of procollagen mRNA were detected by RT PCR .

分析46例系统性硬皮病（SSc）患者血清ENA（盐水可提取抗原）多肽抗体与临床的关系。

The clinical associations with anti ENA polypeptide antibodies in the sera of 46 patients with systemic scleroderma ( SSc ) were analyzed .

目的观察局部注射透明质酸钠（SH）或透明质酸酶（HD）治疗晚期限局性硬皮病（ASC）的临床效果，并进行比较分析。

Objective To compare the curative effects of sodium hyaluronate ( SH ) or hyaluronidase ( HD ) to treat the patients with advanced scleroderma circumscriptum ( ASC ) .

应用免疫学的方法检测了39例限局性硬皮病患者sIL－2R、TNFα、T淋巴细胞正群和淋巴细胞增殖率。

SIL-2R ( soluble interleukin-2 receptor ), TNF α( tumor necrosis factor - α), T-lymphocyte subgroup and proliferation rate of T-lymphocyte in 39 localized scleroderma patients were examined by immunoassay .

胃癌与相关胃肠激素的关系研究进展测定了10例健康志愿者及10例硬皮病（PSS）患者进餐前后胃肠道压力及血浆中胃肠激素的变化。

To investigate the characters of motor pattern and the release of GI hormones in progressive systemic sclerosis ( PSS ), 10 patients with PSS and 10 healthy subjects were studied .

国立卫生研究所正在进行一个称为SCOT的试验项目&对于硬皮病：环磷酰胺还是移植？

The procedure is the subject of a National Institutes of Health study called the SCOT trial , for Scleroderma : Cyclophosphamides or Transplantation ?

结论：系统性硬皮病肺纤维化HRCT表现与临床病程有一定的关系，在病情发展的后期常出现纵隔淋巴结肿大、食管扩张和肺动脉高压等合并症。

Conclusion : HRCT findings have good correlation with disease duration , frequently accompanying with mediastinal lymphadenopathy , esophageal dilatation and Pulmonary artery enlargement during the late period of the diseases .

结缔组织病（CTD）包括许多种疾病，如红斑狼疮、硬皮病、类风湿关节炎、干燥综合征、皮肌炎/多发性肌炎及血管炎等。

Connective tissue disease ( CTD ) includes many diseases . For instance , lupus erythematosus , scleroderma , rheumatoid arthritis , sjogren syndrome , dermatomyositis / multiple myositis and vasculitis .