直系同源

直系同源蛋白在蛋白质互作网络中的特性及其受到microRNA调控的特点研究

Ortholog proteins are inclined to be hubs in protein-protein interaction network and targets of microRNA regulation

网络界面显示了包括一个挑选的疾病基因的所有直系同源聚类。

The web interface presents all ortholog clusters that include a selected disease gene .

为了预测原核生物中的直系同源关系，我们开发了一种新的算法，称之为GOST（GloballyOptimizedSTrategy）。

We developed a novel algorithm called GOST ( Globally Optimized STrategy ) to detect the orthologous relationship between prokaryotic genomes .

通过对脊椎动物y-box基因的系统发育分析显示，Y-box基因是在进化过程中通过基因复制或选择性剪接来产生直系同源基因与旁系同源基因，进而使Y-box基因家族成为一个多功能的基因家族。

During the process of vertebrate evolution , the orthologs and paralogs genes were generated by gene duplication or alterative splicing , which may lead to the Y-box gene for a multifunctional protein family .

我们假定功能特异的蛋白与所对应的旁系和直系同源的CNEs相关联，结果发现CNEs往往与转录因子一起起作用。

We assume that functional specificity of proteins associated with CNEs is assumed to be conserved among orthologs and paralogs . The results indicate that most enriched genes flanking in CNEs are associated with the transcription factors .

判定直系同源关系的进化分析方法

A Evolutionary Approach to Identification of Orthologous Relationship Across Proteomes

以及蛋白质序列数据库、蛋白质资源信息系统和直系同源蛋白质家族数据库等。

Protein sequence databases SWISSPROT and PDBseq , protein information resource InterPro and COG were also integrated in the platform .

通路信息也由总结了不同生物间直系同源的和旁系同源的基因组群的直系同源组群表所描绘。

The pathway information is also represented by the ortholog group tables summarizing orthologous and paralogous gene groups among different organisms .

尽管信号传导因子的序列分化较大，但系统进化分析显示它们在不同昆虫间呈明显的直系同源关系。

Phylogenetic analysis showed that the signal transducers have remarkable orthologous relationships between different insect species in spite of the divergent sequences .

许多它们的基因与人类基因共享一个共同的祖先和功能，这对直系同源基因是特别正确的。

Many of their genes share a common ancestry and function with human genes , and this is particularly true for orthologous genes .

开发能够代表所有动物基因家族精确进化历史的资源库并提供可靠的直系同源物分类。

It aims to develop a curated resource that presents the accurate evolutionary history of all animal gene families , as well as reliable ortholog and paralog assignments .

使用直系同源蛋白作为研究对象，在所有物种中所受的蛋白质水平选择压力一致，能够获得真实的基因组核苷酸组成偏好对蛋白质组成的影响。

The use of orthologous proteins as a study object , in all species suffered the same protein level of selection pressure , to obtain the true protein composition affecting by composition of the genome .

其次，我们发现，热血动物的直系同源基因间具有比较相似的密码子偏好模式，这暗示了小鼠的密码子使用偏好在热血动物共同祖先出现时已基本固定。

Second , we indicated that there were similar patterns of codon usage among orthologous genes of warm-blood vertebrates . These results suggested that the codon usage biases of mouse genes were formed in the common ancestor of warm-blood vertebrates .