瘦素

结论瘦素基因nt+19A→G变异影响中国人2型糖尿病局部体脂分布，且主要影响腹部皮下脂肪的分布。

Conclusion The nt + 19 A → G variant in the LEP gene contributes to the regional body fat distribution in type 2 diabetic Chinese , especially the adbominal subcutaneous adipose depots .

目的探讨血清瘦素水平，瘦素受体变异与乳腺癌发生的关系。

Objective To explore the relations between blood LEP level , LEP receptor variation and breast cancer .

瘦素对大鼠肝细胞蛋白激酶C蛋白表达的影响

Effects of leptin on the protein expression of PKC in rat hepatic cells

甲状腺激素对大鼠血清瘦素及其mRNA水平的影响

Influence of Thyroid Status on Serum Levels of Leptin and Leptin mRNA in Rats

男性早发稳定型心绞痛患者血浆瘦素、C反应蛋白和胰岛素抵抗的相关性研究

The levels of leptin , C-reactive protein and insulin resistance and their relationships in male patients with premature stable angina pectoris

2型糖尿病下肢血管病变患者中瘦素、白介素-6，C反应蛋白的改变

Alterations of serum leptin , interleukin-6 , C-reactive protein during lower limb peripheral arterial disease in patients with type 2 diabetes

【结论】以逆转录聚合酶链反应方法成功地构建了人瘦素基因cDNA克隆。

Conclusions The human leptin gene cDNA clone was constructed by RT PCR .

空腹胰岛素、性别、超敏C反应蛋白、颈动脉内膜中层厚度为影响瘦素的最为显著的因素。

Fasting insulin , sex , allergic c-reactive protein , carotid intima-media thickness of influence of leptin is the most significant factors . 4 .

瘦素（Leptin）在绵羊妊娠早期的激素水平研究

The Leptin in earlier period gestation for sheep hormone level of research

【目的】构建人瘦素基因cDNA克隆，并进行序列分析。

Objective To construct the cDNA clone and analyze the sequence of human leptin gene .

目的探讨在高血压病患者中，TNFα、瘦素水平及其两者水平在肥胖型高血压患者中是否升高。

Objectives To study the serum levels of leptin and TNF - α in essential hypertensive patients .

结论瘦素受体基因内含子2发生碱基改变可能引起瘦素受体基因RNA剪切异常，导致产生异常的瘦素受体；

Conclusions The variation in intron 2 may result in abnormal splicing of leptin receptor gene RNA .

瘦素（Leptin）与体力活动的研究综述

A Review of Leptin in Physical Exercise

而且随着体内营养状态改变而变化的瘦素水平，促进THmRNA表达的变化。

Moreover , the altered levels of leptin according to the nutritional condition facilitated the variation of TH mRNA expression .

目的观察营养性肥胖大鼠血清中瘦素（leptin）、雌二醇（E2）水平和卵巢发育情况。

Objective To observe the serum levels of leptin and estradiol , ovary development .

方法对400例T2DM患者进行临床、生化、瘦素、C肽与肝脏超声检查。

Methods Biochemical test , leptin , C-peptide and liver ultrasound examination were carried in 400 patients .

瘦素（Leptin）与动物生殖调节

Leptin and Regulation of Animal Reproduction

应用免疫组织化学ABC法对大脑切片进行染色，一抗为特异性羊抗瘦素受体IgG。

Immunohistochemistry ABC method was used for brain sections with high specify goat antiserum against leptin receptors .

目的：探讨外周血瘦素（leptin）水平与胰岛B细胞功能、胰岛素抵抗性（InsulinResistance，IR）的关系。

Objective : To investigate the relationship between fasting serum leptin levels ( leptin ) and pancreatic islet B cell function , insulin resistance .

血瘦素水平与ISI值呈显著负相关。

The plasma leptin level was negatively correlated with ISI .

肥胖大鼠血清瘦素、IL-6水平增高，可能参与了肥胖相关胰岛素抵抗；

Increased levels of serum leptin and IL-6 in high-fat diet induced obese rats may contribute to insulin resistance .

结论（1）瘦素不直接影响体外培养颗粒细胞E2、P的分泌，可能通过影响其它因子的作用而间接调节卵巢功能；

Conclusions : ( 1 ) Leptin alone produced no direct effect on the secretion of E_2 and P from granulosa cells in vitro ;

2型糖尿病性脂肪肝瘦素、GSH-PX等相关因素的分析

The Correlative Factor Analysis of Leptin Glutathione Peroxidase in Type 2 Diabetic Fatty Liver

目的：为了便于追踪瘦素（Leptin）在体内的去向，对其进行体内定位，设计合成Leptin荧光分子蛋白探针。

AIM : To track the trace of Leptin in vivo , designing constructing the Leptin fluoresent protein probe .

其中4例患者接受了24h血清瘦素节律的研究。

The rhythm of 24 h serum leptin secretion was studied in 4 patients with AN .

瘦素和游离瘦素指数与各体格指标呈显著正相关（r值为0.54～0.76），而可溶性瘦素受体则与各指标呈显著负相关（r值为-0.23～-0.42）；

Leptin and FLI were positively , and SOB-R negatively correlated with morphological indices ( correlation coefficients from 0.54 to 0.76 , -0.23 to - 0.42 , respectively ) .

目的：克隆人肥胖基因瘦素蛋白（leptin）编码区cDNA序列，并构建其原核表达载体。

Objective To clone the sequence of cDNA of human obese gene ( leptin ) coding area and construct a prokaryotic expression vector .

结论肝组织瘦素受体表达减弱是NAFLD瘦素抵抗的重要病理机制之一，瘦素抵抗与胰岛素抵抗相互作用，共同促进了脂肪肝的发生发展。

Leptin resistance and insulin resistance interact to accelerate the development of NAFLD .

瘦素最高峰男孩一般在唐纳生殖期（G）2-3到达，女孩则在整个青春期继续增长，且在月经初潮后有一个特殊增长。

The leptin peak is reached at Tanner genital stage ( G ) 2-3 in boys , but in girls leptin continues to rise through puberty with a particular increase after menarche .

90分钟游泳运动能有效减轻高脂饮食小鼠的体重、左侧附睾脂肪垫重量、改善血清HDL-C、瘦素水平；

90-minutes swimming can reduce the bodyweight , epididymal fat pad weight and improve serum HDL-c , leptin .