疟疾疫苗

目前疟疾疫苗主要历经减毒疫苗、亚单位疫苗和DNA疫苗三种形式。

At present , there have been three types of malaria vaccine : attenuated vaccine , subunit vaccine and DNA vaccine .

结果提示，HBsAg颗粒有可能成为疟疾疫苗良好的蛋白载体。

It is possible that HBsAg particle be a good carrier for malaria vaccine .

然而因该蛋白结构复杂，至今尚无合适的蛋白合成系统表达和制备出理想的重组CSP作为疟疾疫苗应用。

However so far there is no any protein expression system that is feasible for expression of protein and preparation of CSP as malaria vaccine for use .

其中一项产品，RTS，S候选疟疾疫苗目前正在非洲处于大规模三期临床试验阶段。

One of these products , the RTS , S candidate malaria vaccine , is now undergoing a very large phase III trial in Africa .

最近MontedeiPaschidiSiena基金会也加入这一努力，该基金会以前从未为疟疾疫苗项目提供资金。

They have recently been joined in this endeavor by the Fondazione Monte dei Paschi di Siena who had never before funded malaria vaccine projects .

疟原虫环子孢子蛋白（CSP）蛋白是平均分布在疟原虫子孢子上的一层表被蛋白，是恶性疟原虫子孢子时期的重要保护性抗原，也是疟疾疫苗研究中的重要候选抗原之一。

Circumsporozoite protein distributed in surface of plasmodium sporozoite ring is one of the most important protective antigens for plasmodium falciparum in sporozoite period . Therefore it is also one of the important malaria vaccine candidates .

《自然》的另一篇特写文章报道了被誉为世界上最先进的疟疾疫苗的RTS，S，这种疫苗将很快进入临床试验的最后一个阶段。

A separate article in Nature reports on RTS , S dubbed " the world 's most advanced malaria vaccine " which may shortly reach the final phase of clinical trials .

但在被问及让全球人都能上网是否比找到疟疾疫苗更重要时，微软（Microsoft）联合创始人、世界第二富豪盖茨丝毫不掩饰自己的愤怒：“优先普及互联网？这简直是开玩笑。”

But asked whether giving the planet an internet connection is more important than finding a vaccination for malaria , the co-founder of Microsoft and world 's second-richest man does not hide his ­ irritation : " As a priority ? It 's a joke . "

Plowe和他的同事研究了疟疾疫苗中使用的一种特殊蛋白MSP-119。

Plowe and colleagues looked at a specific parasite protein , MSP-119 , used in malaria vaccines .

葛兰素史克公司在研制RTS.S的搭档“疟疾疫苗开发计划”的ChristianLoucq说这种效力“是我们曾期待的积极一面”。

This efficacy was " on the positive side of what we were expecting , " says Christian Loucq of the PATH Malaria Vaccine Initiative , GSK 's partner on RTS , S.

由于疟原虫的生活史复杂、抗原具有期特异性和变异性以及宿主MHC限制性，一个有效的疟疾疫苗应由多期多种抗原组成。

Because of complexity of the parasite 's life cycle , stage specificity and variation of the antigen and host MHC restriction , an effective malaria vaccine in principle should be composed of multiple antigens derived from different stage of the parasite to generate a multistage , multivalent vaccine .

从未有任何其它疟疾疫苗达到这一程度。

We have never had a malaria vaccine get that far .

嗯，哪一个更重要，网络连通性还是疟疾疫苗？

Hmm , which is more important , connectivity or malaria vaccine ?

其它疟疾疫苗尚处于早期研究阶段。

Other malaria vaccines are at earlier stages of research .

目前仍然没有疟疾疫苗。

There are still no available vaccines against malaria .

科学家们最近证实，研发一种疟疾疫苗是可能的。

Scientists have recently confirmed that it is possible to develop a malaria vaccine .

目的克隆并表达恶性疟原虫重组复合抗原，为疟疾疫苗研究奠定基础。

Aim Cloning and expressing the protective epitopes of Plasmodium falciparum antigens as malaria vaccine .

目前没有获得批准的疟疾疫苗。

There are no approved malaria vaccines .

研发安全有效的疟疾疫苗是当前全球疟疾防治的重要需求。

It remains an urgent need to develop effective malaria vaccine for global control of malaria .

耐药性是一项重大威胁，而未来的疟疾疫苗是一个潜在的机会。

Drug resistance is a major threat , a future malaria vaccine is a potential opportunity .

在设计疟疾疫苗的过程中，必须克服不同个体的遗传基因限制性问题。

The design of a malaria vaccine must overcome genetic restriction to be effective to a diverse population .

作用于红细胞前期的疟疾疫苗主要是抑制疟疾的临床发作，控制疟疾的传播；

The pre erythrocytic stage vaccines aim to prevent the development of all clinical symptoms and subsequent malaria transmission .

“我很激动，”葛兰素史克生物技术公司主持了这个疟疾疫苗项目的乔·科恩说。

" I am thrilled ," says Joe Cohen , who leads the malaria vaccine project at GSK Biologicals .

因此，对疟疾疫苗候选抗原以及恶性疟原虫产生抗药性的机制进行研究已成为当前国内外的研究热点。

Therefore study of malaria vaccine candidate antigens and drug-resistant mechanism of falciparum has become a hot spot at present .

近年来，多种国家科技计划和国际上研究经费的投入也促进我国疟疾疫苗的研发工作。

The availability of various national research programs and international funding has stimulated laboratory and pre-clinical studies of malaria vaccine candidates .

因此，研制高效疟疾疫苗是控制和消灭疟疾的重要途径。

While an effective malaria vaccine is not yet available , considerable insight has been gained in the complex , mu .

科学家说，发现不同疟原虫种群的共有基因可能有助于疟疾疫苗的开发。

Research identifying common genes between different populations of malaria parasites could lead to the development of a vaccine , say researchers .

数十年来，科学家一直努力研制一种抗疟疾疫苗，但是寄生性疟原虫是一个很难对付的敌人。

Scientists have been working for decades to develop a vaccine against malaria , but the Plasmodium parasite is a formidable foe .

几种正处于开发阶段的实验性疫苗（包括大流行性流感疫苗和疟疾疫苗）也添加了角鲨烯，用于增强疫苗效力。

Squalene is being added to improve the efficacy of several experimental vaccines including pandemic flu and malaria vaccines which are being developed .

一种疟疾疫苗在马里的小规模成年人临床实验中表现良好，如今试验将扩展到儿童。

A malaria vaccine has performed well in a small clinical trial of adults in Mali , leading to testing being expanded to children .