甲基天冬氨酸

阿尔茨海默病大鼠海马N-甲基天冬氨酸受体和丝裂酶原激活蛋白激酶的表达

Expression of MAPK and NMDAR in the hippocampus of Alzheimer rat

以马来酸、甲醇、甘氨酸、氯化氢为主要原料，合成了N-羧甲基天冬氨酸。

N-carboxymethyl-aspartic acid was synthesized with malic acid , methanol , glycine , hydrochloric acid .

母体免疫球蛋白G对N-甲基-D-天冬氨酸诱导婴儿痉挛大鼠模型的作用及其对脑内促肾上腺皮质激素表达的影响

Effect of Maternal Immunoglobulin G on N-Methyl-D-Aspartate-Induced Infantile Spasms Rat Model and on Adrenocorticotrophic Hormone Expression in Brain

皮下注射N甲基DL天冬氨酸是诱发雌性大鼠真性性早熟的有效手段。

Subcutaneous injection of NMA is an effective means to induce true precocious puberty in female rats .

N-甲基-D-天冬氨酸受体（NMDA受体）是中枢神经系统中兴奋性递质谷氨酸受体的一种类型，属于离子型受体。

NMDA receptors are a subtype of excitatory transmitters-glutamate receptor in the central nervous system .

突触N-甲基-D-天冬氨酸（NMDA）受体的增加可能会控制使这种修饰的发生降低。

An increase in synaptic NMDA receptors may control the ease with which such modifications take place .

近年来研究表明，N甲基D天冬氨酸（NMDA）对神经和内分泌具有重要的调控作用。

Recently , studies have shown that N-methyl-D-aspartic acid ( NMDA ) plays an important role in regulation of the nervous tissues and endocrine glands .

目的研究中枢N甲基D天冬氨酸受体（NMDA）系统的功能变化与吗啡依赖大鼠戒断症状的关系。

Objective To study the relation between the level of central NmethylDaspartate ( NMDA ) receptor system and the degree of morphine withdrawal syndrome in rats .

目的探讨吡咯喹啉醌（PQQ）对N甲基D天冬氨酸（NMDA）诱发海马神经元损伤的影响。

ObjectiveTo investigate the protective effect of pyrroloquinoline quinone ( PQQ ) on damage of hippocampal neurons induced by NMDA .

目的观察外周神经切断后初级感觉神经元内N-甲基-D-天冬氨酸（NMDA）受体表达的改变。

Objective To observe the effect of axotomy on the expression of NMDA receptors in the primary sensory neurons of rats .

目的：观测N－甲基－D－天冬氨酸（NMDA）受体在脑损伤后的变化规律以及与继发性脑水肿发生和发展的关系。

AIM To study the changes of NMDA ( N-methyl-D-aspartate ) receptor activities and its relationship to secondary brain edema after brain injury .

目的：探讨兴奋性氨基酸、N甲基D天冬氨酸受体（NMDAR）在大鼠百日咳杆菌脑损伤中的变化及作用机制。

Objective : To explore changes and mechanism of EAAs and its specific N-methyl-D-aspartate receptor ( NMDAR ) on bordetella pertussis brain injury in rats .

近年来研究发现N-甲基-D-天冬氨酸（NMDA）受体参与阿片成瘾的形成。

Recently more researches focus on the N-methyl-D-aspartate ( NMDA ) receptor , which involves in development of addiction through interaction with dopamine receptor .

假手术模型组与正常组比较，N-甲基-D-天冬氨酸受体2B亚单位蛋白在海马CA1、CA3区锥体层神经元表达灰度值未见显著性变化。

There was no significant difference in the gray scales between the sham-operation group and the normal group .

因此探讨慢性内脏炎痛刺激及吗啡耐受间共同的细胞机理及N甲基D天冬氨酸（NMDA）受体相关的调节机理，为合理用药及药物开发提供实验依据。

In the present study , the common cellular mechanism of chronic visceral inflaming pain and morphine tolerance and the regulation of N methyl D aspartate ( NMDA ) receptor were investigated .

目的：研究神经毒性物质β-淀粉样肽（β-AP）？N-甲基-D-天冬氨酸（NMDA）对原代培养鼠脑皮层神经细胞的致凋亡损伤和维生素E可能的神经保护作用？

Objective : To study apoptosis of the cultured rat brain neurons induced by β - amyloid peptide (β - AP ) and N-methyl-D-aspartate ( NMDA ) and neuro-protective effect of vitamin E.

N-甲基-D-天冬氨酸受体（N-methyl-D-aspartateReceptor，NMDAR）是离子型的Glu受体之一，介导由Glu及其他相关内源性酸性氨基酸的兴奋作用。

The N-methyl-D-aspartate receptor ( NMDAR ) is an ionotropic Glu receptor which medicates the excitation function of Glu and other relative endogenous acidic amino acid .

方法神经元与不同浓度米诺环素和（或）N甲基D天冬氨酸（NMDA）作不同时间处理后，观察细胞形态，并以MTT试验评价细胞活性。

METHODS Cortical neurons were isolated from new born rats , primarily cultured for different days , treated by minocycline and / or N methyl D aspartate ( NMDA ) at different concentrations for different durations .

目的探讨母体免疫球蛋白G（IgG）对N-甲基-D-天冬氨酸（NMDA）诱导婴儿痉挛大鼠模型的临床作用及其对脑内促肾上腺皮质激素（ACTH）免疫反应阳性细胞表达影响。

Objective To explore the effect of maternal immunoglobulin G ( IgG ) on N-methyl-D-aspartate ( NMDA ) induced infantile spasms rat model and on the adrenocorticotrophic hormone ( ACTH ) expression in brain .

目的探讨N甲基D天冬氨酸（NMDA）受体拮抗剂MK801对新生大鼠缺氧缺血（HI）后半胱天冬酶3（Caspase3）激活及凋亡的影响。

Objective To study the effect of MK 801 , the antagonist of NMDA receptor , on caspase 3 activation and apoptosis after cerebral hypoxic ischemic injury in neonatal rats .

目的N-甲基-D-天冬氨酸受体离子通道拮抗剂美金胺对缺氧缺血具有明显的脑保护效果，观察重复应用大剂量美金胺对SD新生大鼠可能造成的不良影响。

AIM : N-methyl-D-aspartate receptor ionic channel antagonist , memantine has significantly cerebral protective effects on hypoxic / ischemic rats . To observe the side effects of repetitive application of memantine at big dosage in SD neonatal rats .

腺苷抑制P2X7和N-甲基-D-天冬氨酸受体诱导的视网膜神经节细胞死亡

Inhibiting effect of adenosine on retinal ganglion cells death induced by P2X_7 and N-methyl-D-aspartate receptors

目的探讨γ羟丁酸钠（GHBNa）对缺氧缺血后脑损伤新生大鼠有无保护作用及N甲基D天冬氨酸受体2B亚基（NR2B）与脑损伤的关系。

AIM To investigate if sodium gamma-hydroxybutyrate ( GHB-Na ) could protect neonatal rats from hypoxia-ischemia and the relationship between N-methyl-D-aspartate receptor 2B subunit ( NR2B ) expression and brain injury .

目的探讨高胆红素血症新生鼠海马区Fas蛋白、N-甲基-D-天冬氨酸（NMDA）受体的表达、神经细胞凋亡率及其间相关性，以进一步阐明胆红素的神经毒性机制。

Objective To explore the expression of Fas pretein , N-methyl-D-aspartate ( NMDA ) receptor , the rate of neuronal apoptosis in the hippocampus under the hyperbilirubinemia and elucidate the molecular mechanism of bilirubin neurotoxicity .

结论脊髓背角神经元的异位放电是形成中枢敏化的重要原因之一，可能与N-甲基-D-天冬氨酸（NMDA）受体有关。

Conclusion NMDA receptor activation contributes to the generation of ectopic discharges in WDR of the spinal dorsal horn and NMDA receptor may play an important role in the genesis of neuropathic pain .

目的：观察N-甲基-D-天冬氨酸（NMDA）对耳蜗电位的影响，探讨NMDA对耳蜗的神经毒性作用。

Objective : To investigate the effect of N methyl D aspartate ( NMDA ) on cochlear potentials and to find out the possible neurotoxic effect of NMDA on cochlea function in guinea pigs .

目的：建立体外培养神经细胞N-甲基-D-天冬氨酸（N-methyl-D-aspartate，NMDA）损伤及地佐环平（MK-801）保护作用模型。

AIM : To establish the in vitro cultured model of neuroprotective and injury effects by N methyl D aspartate ( NMDA ) and dizocilpine ( MK 801 ) .

通过测定小鼠前脑N甲基D-天冬氨酸受体（N-methyl-D-aspartateReceptor，NMDA-R）的转录水平的变化，研究中低浓度甲醛暴露环境对小鼠中枢神经系统的影响。

The effects of middle and low concentrations of inhaled formaldehyde exposure on central nervous system were studied in this research by examining the transcriptional changes of N-methyl-D-aspartate receptor ( NMDA-R ) in mice fore cerebrum .

目的：通过观察大鼠结肠炎不同时期脊髓背角N-甲基-D-天冬氨酸受体（NMDAR）的表达，探讨突触后NMDAR在内脏高敏感性中的作用。

Objective To investigate the effects of N-methyl-D-aspartate receptor ( NMDAR ) in the spinal dorsal horn in visceral hypersensitivity in rats with colonic inflammation .

雌孕激素对鼠脑皮层及海马N-甲基-D-天冬氨酸受体亚单位1mRNA表达的影响

Effects of estrogen and progestin on the expression of NMDA receptor subunit 1 mRNA in rat ′ s cerebral cortex and hippocampus