汉防己

可乐定和汉防己碱抑制高血压大鼠动脉平滑肌DNA合成速率

Inhibition of aortic DNA synthesis by clonidine and tetrandrine in renal hypertensive rats

汉防己甲素预防实验性糖尿病大鼠胰岛B细胞损伤作用的组织学观察

Histology observation of preventive effect of tetrandrine on islet B cells injury in experimental diabetes rats

结论1.以丹参、H七、桃仁、汉防己为主组成的中药制剂能够保护肝功能，对肝纤维化有防治作用。

Chinese herbs can protect hepatic function , and prevent and cure hepatic fibrosis .

汉防己甲素抑制矽肺胶原mRNA表达的研究

Inhibition of mRNA Expression of Silicotic Collagen Gene by Tetrandrine

汉防己甲素对气管平滑肌~（45）Ca内流的影响

Effects of tetrandrine on ~ ( 45 ) ca influx in tracheal smooth muscles

汉防己甲素联合柔红霉素对K562/A02细胞株P21蛋白和P糖蛋白表达的影响

Effect of Tetrandrine Combined with Daunorubicin on Expressions of P21 and P-gp in K562 / A02 Cells

汉防己甲素联合屈洛昔芬对K562细胞bcr/abl表达的影响

Tetrandrine combined with Droloxifene affect the Expression of bcr / abl in K562 cell

蛋白质芯片检测多药耐药蛋白，是以细胞株（K562和K562/A02）、汉防己甲素和屈洛昔芬单独或联合作用的K562/A02耐药细胞及部分临床样品为实验研究对象。

K562 , K562 / A02 and clinic sample were used in the study .

目的探讨汉防己甲素对肾小球硬化大鼠肾脏转化生长因子（TGFβ1）基因表达的影响。

Aim The effect of tetrandrine on TGF - β 1 mRNA expression in glomerulosclerosis rat was observed .

提示抑制NOS活性和NO生成是汉防己甲素防治肝硬化门脉高压症的主要作用机理。

The vitally preventing mechanism of cirrhosis and portal hypertension is inhibiting the enzymatic activity of NOS.

汉防己甲素对四氧嘧啶致大鼠血清LPO含量及全血GSH&Px活性改变的影响

Effects of tetrandrine on the change of serum LPO level and blood GSH-Px activities induced by alloxan in rats

汉防己甲素干预后的生长抑制曲线一致，无明显差异（P＞0.05）。Tet干预后两种细胞均出现凋亡现象，透射电镜看到凋亡小体。

Their growth suppression curve were coincidence , and apoptotic body being seen in the cells with transmission electron microscope .

方法：以风湿镇痛凝胶中汉防己碱为指标，采用Franz小池扩散法。

Methods : Adopting Franz diffusion cell and using tetrandrine as an index .

汉防己甲素通过减少肺组织中炎性细胞因子IL-1α、IL-6、TNF-α的含量，抑制照射后诱发的炎性反应。

The Tet through inhibition of inflammatory cytokines IL-la , IL-6 , TNF-a expression , thus inhibiting irradiation-induced inflammatory response . 3 .

结果：复方汉防己治疗组肝纤维化评分明显低于生理盐水对照组，血清HA及结蛋白阳性细胞数明显减少。

Results : The serum hyaluronic acid ( HA ), fibrosis score and desmin positive cells were all decreased in treatment group as compared to control group .

由CCl4诱发的肝纤维化实验大鼠，经汉防己甲素（tetrandrine，Tet）治疗证明：Tet有确实可靠的抗肝纤维化作用。

Hepatic fibrosis of rat was induced by CCl_4 and treated with tetrandrine ( Tet ) .

汉防己甲素对膀胱肿瘤细胞BIU-87及BIU-87/ADM作用的实验研究

The Study of Tetrandrine Affecting to BIU-87 and BIU-87 / Adm Cells

联用组大鼠肝组织中胶原蛋白含量低于汉防己甲素干预组和川芎嗪干预组，差异显山冠穿医科口弋学硕d二学t立金仑文著（P0.01）；

Collagen content of the combination treated group is significantly lower than those of the tetrandrine treated group and the tetramethylpyrazine treated group ( P0.01 ) .

复方汉防己冲剂组EV与对照组相比有显著减轻（P<0.05）。

The changes of EV in treatment group was more obvious compared with that in controlled group ( P < 0.05 or 0.01 ) .

结论汉防己甲素能诱导人神经母细胞瘤株TGW凋亡，上调Bax基因的表达。

Conclusions Tetrandrine could promote apoptosis of neuroblastoma cell line TGW and up-regulate the expression of Bax gene .

用CCl4造成大鼠肝纤维化模型，用汉防己甲素进行抗肝纤维化治疗，并与传统抗肝纤维化药物秋水仙碱进行比较。

Tetrandrine was used to treat liver fibrosis induced by CCl4 in rats , and its action was compared with colchicine .

目的研究汉防己甲素（TTD）对慢性粒细胞白血病急性变白血病细胞株K562/ADM多药耐药（MDR）逆转的机理。

Objective To investigate the reversal mechanism of Tetredrine ( TTD ) on multidrug resistance in leukemia cell line K562 / ADM.

目的探讨汉防己甲素（Tet）对慢性低氧性肺动脉高压大鼠肺组织胶原含量的影响。方法雄性大鼠30只，随机分为：（1）对照组10只，不缺氧处理；

Objective To investigate the effect of tetrandrine ( Tet ) on the collagen contents of lung tissues in rats with chronic hypoxic pulmonary hypertension .

结果汉防己甲素治疗组肝内Ⅰ、Ⅲ型胶原蛋白的含量明显下降，与生理盐水对照组及未治疗组比较，差异有显著性（P0.01）。

Results The content of collagen type ⅰ and type ⅲ in the group of TTD was significantly reduced comparing with normal saline group and untreated group , the difference was significant ( P0.01 ) .

目的评价汉防己甲素（Tet）肺靶向微球对低氧性肺动脉高压的治疗效应及其对肺循环的选择性作用。

Objective To assess the effect of tetrandrine ( Tet ) pulmonary targeting microspheres on hypoxic pulmonary hypertension and evaluate its selective action on pulmonary circulation .

在急性分离的大鼠大脑皮层神经元上，用膜片钳单通道记录技术研究汉防己碱（Tet）对电压依赖性钙通道的影响。

The effects of tetrandrine ( Tet ) on calcium channels in acutely isolated rat conical neurons were studied using the patch clamp single channel recording technique .

汉防己甲素对过敏性迟缓反应物质（SRS-A）的作用

Anti - SRS - a effect of tetrandrine

目的：初步研究汉防己甲素（Tet）联合屈洛昔芬（DRL）对K562细胞株凋亡相关因子bcr/AblmRNA及蛋白表达的影响。

Objective : to primarily study the effects of Tetrandrine ( Tet ) combined with Droloxifene ( DRL ) on the mRNA and protein expression of the apoptosis related factor of bcr / abl in K562 cell line .

目的观察汉防己甲素（Tet）对急性脊髓损伤（ASCI）的保护作用，并从自由基损伤的角度探讨其对ASCI的作用机理。

Objective To study the protective effect of tetrandrine ( Tet ) on free radicals of acute spinal cord injury ( ASCI ) in rats and activity mechanism to ASCI from be radicals .

二甲双胍+汉防己甲素组：每8小时尾静脉注射1.0mg/kg汉防己甲素，3次/d，同时灌胃100mg/穴kg·d雪二甲双胍混悬液。

Tetrandrine + metformin treatment rats were injected with 1.0 mg / kg tetrandrine every 8 hour in vena caudalis , three times a day , meanwhile were treated with gastric perfusion with 100 mg / kg metformin suspension .