水飞

HPLC法测定水飞蓟素胶囊中水飞蓟素异构体的含量

Determination of Six Isomers of Silibin in Silymarin Capsules by HPLC

2比较了灵芝热水提取液、水飞蓟宾、维生素C和利肝隆对α-鹅膏毒肽所致小鼠肝损伤的保护作用。

The protective role of Ganoderma lucidum extract , silybin , vitamin C and Legalon on the amatoxin-induced liver damage were compared .

水飞蓟素对肾小管间质纤维化大鼠核转录因子-κB和细胞间黏附分子-1表达的影响

Effects of Silymarin on Expressions of Nuclear Factor Kappa B and Intercellular Adhesion Molecule-1 in Renal Tissue of Rats with Tubulointerstitial Fibrosis

纳米雄黄组与传统水飞雄黄组中砷的药代动力学参数经统计学分析均有显著差异（P0.05）。

There was a significant difference in pharmacokinetics parameters between nano-realgar group and traditional realgar group .

为深入研究水飞蓟宾与载体分子的相互作用和固体分散体的结构与性能关系，利用红外和X射线衍射技术对二元和三元系固体分散体进行了研究。

In order to study the molecular interaction between the drug and the carriers , IR spectroscopy and X-ray diffraction were measured .

RP-HPLC测定大鼠血浆中水飞蓟宾的浓度

Determination of silibinin concentration in rat plasma by RP-HPLC

方法：水飞炮炙及其前后的性状鉴别、靛蓝、石灰含量与PH值的测定。

Method : The processes of powder-refining with water , as well as anteroposterior properties identify , quantity of lime and indigo and determination of PH.

治疗组中，利肝隆治疗效果最好，其次是水飞蓟宾组，而维生素C组治疗效果不明显。

The best of the treatment group was Legalon and showing a concentration-related , followed by the the silybin group , the vitamin C group has no treatment effect . 3 .

水飞蓟宾对人舌癌细胞Tca的抑制作用

Inhibition effects of silibinin on human tongue cancer cell line Tca

目的探讨水飞蓟宾磷脂酰胆碱复合物（SPC）对脓毒症肝脏损伤的保护作用。

Objective To investigate the hepatoprotective effect of silybin-phosphatidylcholine complex ( SPC ) in sepsis rats .

水飞蓟总黄酮与Fenofibrate合用对大鼠高血脂症的影响

Effects of the compound of silymarin and fenofibrate on hyperlipidemic rats

结果：水飞蓟宾（6.25-50μg／mL）以浓度依赖方式抑制巨噬细胞产生胶原刺激活性和转化生长因子β1。

Results : Silybin ( 6.25-50 (μ g / mL ) inhibited LPS-induced collagen stimulating activities and TGF μ production in a concentration dependent manner . Conclusion : Hepatoprotective and an (?)

水飞蓟宾对人肝星状细胞LX-2凋亡及α1（I）胶原mRNA表达的影响

Effects of silibinin on apoptosis and α 1 ( I ) collagen mRNA expression in human hepatic stellate cells LX-2

研究了水飞蓟宾在玻碳电极（GCE）上的电化学还原行为。

The electrochemical reduction of silybin at the glassy carbon electrode ( GCE ) has been studied .

目的了解水飞蓟宾-卵磷脂复合物（SLC）对大鼠脑缺血-再灌注损伤的保护作用。

Objective To investigate the protective effects of silybin-lecithin compound on cerebral ischemic-reperfusion injury ( CIRI ) in rats .

目的：确定水飞蓟宾卵磷脂复合物（SLC）中水飞蓟宾与卵磷脂之间是以共价键还是以其他次级键结合。

Objective : To confirm whether silybin lecithin complex ( SLC ) is combined by covalent bonds or other sub bonds .

水飞蓟油并能显著降低外源性高脂血症的胆固醇（TC）和甘油三酯（TG）（P＜0.01），降低率分别为83.91%和60.07%。

The cholesterol ( TC ) and triglyceride ( TG )( P < 0.01 ) of exo-genous hyperlipemia can be reduced notably by S.M. G seed oil , the rates of the reduction were 83.91 % and 60.07 %

目的：应用二甲基亚硝胺（DMN）建立肝纤维化大鼠模型，研究水飞蓟宾卵磷脂复合物（SPC）对纤维化肝组织中Ⅰ、Ⅲ型胶原表达的影响。

AIM : To investigate the effects of silybin-phosphatidylcholine compound ( SPC ) on expressions of collagens type I and III in the fibrotic liver .

水飞蓟宾（silibinin）为从菊科植物水飞蓟（Silybummarianum）的种子和果实中提取得到的黄酮类单体成分。

Silibinin is a polyphenolic flavanoid derived from fruits and seeds of milk thistle ( Silybum marianum ) .

由于水飞蓟素在水中几乎不溶，本文首先采用溶剂法，以PVPK30为载体，制备了水飞蓟素固体分散体，以提高水飞蓟素的水溶性。

Due to aqueous insolubility of silymarin , the solid dispersion was prepared by the solvent method using PVP K30 as the hydrophilic carrier matrix .

以特种油料植物水飞蓟种籽为材料，以超临界CO2为溶剂在容量为1L的萃取釜中对水飞蓟油进行萃取。

The special fatty oil in Silybum marianum seeds was extracted with supercritical-CO_2 , and the influences of pressure , temperature , and time on extraction yield were discussed in this paper .

建立水飞蓟素中5种活性成份的HPLC方法，绘制各成份的释放曲线，计算各曲线间相似因子（f2）；

An HPLC method was employed to determine the five active components of silymarin , based on which , the release profiles of the components were drawn and similarity factor f2 values between each two of the profiles were calculated .

此外，我们还发现水飞蓟宾在整体、组织和细胞形态、氧化损伤和ROS水平、MAPK/NF-κB信号通路的激活以及自噬的调节等方面对UVB引起的损伤均发挥了明显的对抗作用。

Besides silibinin also showed strong protection against UVB-induced inflammation from the aspects of global morphology , histochemical and cellular morphology , oxidative damage and ROS level , activation of MAPK / NF - κ B signal pathway and regulation of autophagy .

鸭肝炎病毒（DHV）刺激雏鸭增重和发育及水飞蓟素对其影响的研究

Study on the Potential of Duck Hepatitis Virus ( DHV - ⅰ) to Stimulate the Body Weight Gain and Body Length Gain and the Effects of Silymarin on Them in Younger Duck

目的了解水飞蓟宾-磷脂酰胆碱复合物（SLC）的急性毒性资料，为亚急性毒性、致突变试验及临床应用剂量提供依据。

Objective To find out the data of acute toxicity of silybin-lecithin compound ( SLC ) to provide a suitable quantity for subacute toxicity testing , mutagen testing and to evaluate safety of clinical application .

结果：水飞蓟宾在PVP中以无定型存在，在泊洛沙姆188中以微细结晶存在，在尿素中大部分仍以晶体形式存在，少量以分子状态存在。

Results : In PVP silibinin solid dispersions drug was amorphous ; in poloxamer 188 silibinin solid dispersions , drug existed as fine crystal , while in urea silibinin solid dispersions most of silibinin existed as crystal , only a little as molecule .

结果水飞蓟素磷脂复合物0.28、0.84g/Kgbw剂量能降低ALT、AST活性，减轻肝脏病理损伤（P<0.05）。

Result The silymarin phosphatidylcholine complex can reduce the active of ALT and AST at the dosage of 0.28 、 0.84g/kg BW , and it can reduce the pathological damage on liver ( P < 0.05 ) .

水飞蓟宾通过诱导活性氧产生而导致细胞死亡，其诱导的活性氧主要形式为过氧化氢（H202）和超氧阴离子（02·-）。

Silibinin induced cell death by increasing generation of reactive oxygen species ( ROS ), of which H2O2 and O2 were the major forms .

结论水飞蓟素磷脂复合物对CCI4造成的急性肝损伤有明显的保护作用。

Conclusion The protective effect of silymarin phosphatidylcholine complex aganist acute liver damage by carbon tetrachloride was very obvious .

此外，水飞蓟宾对直接影响A375-S2细胞寿命的端粒酶的活力没有影响。

In addition , silibinin did not show the effect on the activity of telomerase which could directly regulate the life-span of cells .