氢化麦角碱

氢化麦角碱对血管性痴呆小鼠海马组织CaM、CaMPKⅡmRNA动态表达的影响

Effects of Dihydroergotoxine Mesilate on the Dynamic Expression of CaM , CaMPK ⅱ mRNA in Hippocampal Neurons of Mice with Vascular Dementia

目的：观察氢化麦角碱（DHET）治疗脑血管性痴呆（VD）的临床疗效。

Objective : To assess the efficacy of dihydroergotoxine ( DHET ) in treatment of vascular dementia ( VD ) .

结论VD小鼠海马组织CaM、CaMPKⅡmRNA在较长时期内表达减少可能与VD发病相关，而氢化麦角碱可以提高CaM、CaMPKⅡmRNA的表达水平，并改善VD的临床症状。

Conclusions Our study suggest that the lower expression of CaM and CaMPK ⅱ mRNA in hippocampal neurons during a relatively longer time might participate in the pathogenesis of VD . Dihydroergotoxine mesilate may increase the expressions of CaM and CaMPK ⅱ mRNA and improve the clinical symptoms of VD .

方法：将93例VD患者按区组随机法分为激光合电针组、电针组和药物组（氢化麦角碱，DHET），每组31例。

Methods : 93 patients suffering from vascular dementia were randomly divided into three groups , the combination of intravascular He-Ne laser irradiation with electroacupuncture group ( 31 cases ) and the medicine group ( dihydroergotoxine , DHET , 31 cases ) .

氢化麦角碱治疗脑血管性痴呆的疗效观察

Clinical Evaluation of Dihydroergotoxine in Treatment of Vascular Dementia