氟胞嘧啶

两性霉素B和5-氟胞嘧啶合用对隐球菌脑膜炎患者外周血象的影响

Influence on peripheral blood figure from combined amphotericin B and flucytosine in patients with cryptococcus meningitis

结论念珠菌感染中以白色念珠菌最为多见，药敏结果显示氟康唑、氟胞嘧啶、两性霉素B敏感性高；

Susceptibility results show that Candida infections are highly susceptible to fluconazole , flucytosine and amphotericin B ;

该病例经用二性霉素B与5-氟胞嘧啶联合治疗后痊愈。

The case in question is cured by a treatment with amphotericin B5-fluorocytosinum .

真菌对5-氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑总的敏感率分别为93.0%、98.9%、90.8%、59.8%。

The total sensitivity to 5-Fluorocytosine , Amphotericin-B , Fluconazol and Itraconazole were 93 % 、 98.9 % 、 90.8 % and 59.8 % respectively .

在9种抗真菌药药敏试验中，5-氟胞嘧啶、氟康唑、克霉唑、两性霉素B、制霉菌素有较高的敏感性。

Sensitivity results to nine antifungals showed that 5-flucytosine , fluconazole , clotrimazole , amphotericin B , and nystatin had higher drug sensitivity to these fungi .

对两性霉素B、制菌霉素、5-氟胞嘧啶的敏感性最高，保持了较高的抗菌活性，这三种抗菌药仍然是治疗深部真菌感染的有效药物。

Amphotericin B , mycomycin and 5-fluorocytosine were most sensitive to the pathogenic fungi and remain to be the most effective drug to cure deep part infection .

目的：比较对5-氟胞嘧啶耐药与敏感的白色念珠菌DNA基因组与RNA表达，探讨复发性念珠菌阴道炎的耐药机理。

Objective : To investigate the DNA genome and RNA expression in 5 flurocytosine resistant strains of Candida albicans from vaginal candidasis .

体外药敏分析显示：对各种念珠菌的总体敏感率大于90%的抗真菌药物有制霉菌素（94.4%）、伊曲康唑（93.8%）、两性霉素B（93.8%）、5-氟胞嘧啶（91.9）。

The total percentage of susceptibility of Monilia to 5-fluorocytosine , amphotericin B , nystatin and itraconazole were 91.9 % , 93.8 % , 94.4 % and 93.8 % , respectively .

结果：检测出的念珠菌对特比萘芬耐药，对氟康唑、酮康唑、咪康唑、克霉唑中度敏感，对制霉菌素、伊曲康唑、两性霉素B、氟胞嘧啶高度敏感。

Result : Candida species are resistant to terbinafine , medium susceptible to fluconazole 、 ketoconazole 、 miconazole and clotrimazole , high susceptible to nystatin 、 itraconazole 、 amphotericin B and flucytosine .

酵母样真菌对5-氟胞嘧啶、两性菌素B、氟康唑、依曲康唑的敏感性分别为98.02%，98.43%，77.38%，77.76%。

The drug susceptibilities to antifungal drugs of the yeast-like fungi were 98.02 % to 5-flucytosin , 98.43 % to amphotericin B , 77.38 % to fluconazole , and 77.76 % to itraconazole .

白色念珠菌对两性霉素B、氟康唑、氟胞嘧啶和伊曲康唑的敏感性分别为100%、94.6%、92.86%和57.1%。

The rate of C. albicans susceptibility to amphotericin B , fluconazole , flucytosine ( 5-FC ) and itraconazole were 100 % , 94.6 % , 92.86 % and 57.1 % , respectively .

各真菌对5-氟胞嘧啶、两性霉素B、伏立康唑敏感性较高，分别为99.81%、100%、99.17%；对氟康唑、伊曲康唑敏感性较低，分别为94.87%，93.92%。

The sensitivities of the fungi to 5-fluorocytosine 、 amphotericin B 、 voriconazole were high , respectively 99.81 % , 100 % , 99.17 % ; and to fluconazole 、 itraconazole were low , respectively 94.87 % , 93.92 % .

为获得5┐氟胞嘧啶（5┐fluorocytosine，5┐FC）对含CD基因哺乳类细胞的诱导杀伤表型数据。

Objective : To obtain the lethal data of mammalian cells containing CD gene induced by 5 FC ( 5 fluorocytosine ) .

方法回顾性分析15例不同免疫学分级的艾滋病合并新型隐球菌脑膜脑炎，分别应用两性霉素B联合氟康唑或5-氟胞嘧啶治疗，依据卫生部标准判断其预后及不良反应。

Methods 15 patients with HIV / AIDS and cryptococcus meningitis were analyzed retrospectively , who were treated with AMB + 5-fluorouracil ( 5-FU ) or AMB + fluconazole , then the prognosis and adverse reaction were evaluated by the criteria of health ministry .

目的：我们的前期研究显示腺病毒介导的CD／5-FC（胞嘧啶脱氨酶／5氟胞嘧啶）系统对卵巢癌有抑制作用。

Objective : Adenovirus-mediated CD / 5-FC ( Cytosine deaminase / 5-fluorocytosine ) system have been proved can suppress the ovarian cancer cells growth by our previous study .

结果两性霉素B、氟胞嘧啶、氟康唑2种方法完全符合率分别为95.3%、95.3%和88.4%，未出现一种方法敏感而另一种方法耐药的严重错误现象；

Results The coincidence rate of the two methods to amphotericin B , 5-flucytosine and fluconazole was ( 95.3 % ),( 95.3 % ) and ( 88.4 % ) respectively . The sensitive strains detected by one method did not show resistance in another method .

FCU／5-氟胞嘧啶自杀基因前体药物系统联合放射治疗鼻咽癌的实验研究

Combining FCU / 5-FU suicide gene / prodrug system and radiation in treating nasopharyngeal carcinoma : an experimental study

目的：探讨亚叶酸钙（CF）联合5氟胞嘧啶（5FU）对转染胞嘧啶脱氨酶（CD）基因的直肠癌细胞的杀伤作用。

Objective To study antitumor effect of calcium folinate ( CF ) and 5 fluorocytosine ( 5 FU ) on rectal carcinoma cells transfected with cytosine deaminase ( CD ) gene .

目的：探讨两性霉素B（AMB）联合5-氟胞嘧啶（5-FC）治疗新型隐球菌性脑膜炎时对患者外周血象的影响。

AIM : To observe the influence on peripheral blood figure by amphotericin B ( AMB ) combined with flucytosine ( 5 FC ) in the treatment of the patients with cryptococcus meningitis .

目的：探讨5-氟胞嘧啶（5-FC）对基因修饰的胰腺癌细胞凋亡的影响及特征。

AIM : To elucidate the pattern of 5-fluorocytosine ( 5-FC ) induced apoptosis and its role in gene therapy for human pancreatic cancer .

目的探讨5-氟胞嘧啶（5-FC）/CD∷UPRT联合基因系统对大鼠脑胶质瘤的治疗作用。

Objective To investigate the therapeutic effects of 5-FC / CD ∷ UPRT combinative gene on encephalic glioma xenograft in SD mice .

目的研究胞嘧啶脱氨酶基因（CD）联合前体药物5氟胞嘧啶（5Fc）对结肠癌细胞的生长抑制作用。

Objective To investigate the effect of cytosine deaminase ( CD ) gene plus 5 fluorocytosine ( 5 Fc ) on the growth of human colon cancer xenograft in nude mice .

该基因可在干细胞中将毒性小的5-氟胞嘧啶（5-FC）转变为5-FU，该化疗药物由干细胞进入肿瘤细胞，产生致死性的旁观者效应。

This gene can convert a less toxic drug , 5-fluorocytosine ( 5-FC ), to5-FU inside the stem cells , and the chemotherapy can then seep out into the tumor , producing a lethal by-stander effect .

给予前体药物5-氟胞嘧啶（5-FC）和/或无环鸟苷（GCV）后，MTT法测定细胞的存活率，流式细胞仪检测细胞的凋亡率。

After prodrug GCV or / and5-FC were administered , MTT method was used to detect the growth rate of T lymphocytes and flow cytometry ( FCM ) was used to evaluate the apoptosis rate of T lymphocytes .

目的探讨人端粒酶逆转录酶（hTERT）启动子调控下的融合双自杀基因&胞嘧啶脱氨酶胸苷激酶/5氟胞嘧啶+更昔洛韦（cdtk/5FC+GCV）系统对人卵巢癌细胞及正常细胞的体外杀伤作用。

Objective To investigate the in vitro effects of cytosine deaminase-thymidine kinase / 5-fluorocytosine + ganciclovir ( CD-TK / 5-FC + GCV ) on ovarian cancer cells and normal cells using a human telomerase reverse transcriptase ( hTERT ) promoter-driven vector system .

结果：酮康唑、氟胞嘧啶和伊曲康唑对102株白色念珠菌MIC较低，其MIC90分别为0.25μg/ml、0.5μg/ml和0.5μg/ml。两性霉素B和氟康唑MIC90分别为2μg/ml和8μg/ml。

Results : The respective 90 % MICs ( MIC 90 ) of ketoconazole , 5 flucytosine , itraconazole , amphotericin B and fluconazole against 102 isolates of Candida albicans were 0.25 , 0.5 , 0.5,2 and 8 μ g / ml.

目的探讨联合应用尿嘧啶磷酸核糖转移酶（UPRT）基因对胞嘧啶脱胺酶（CD）/氟胞嘧啶（5-FC）前药转换酶系统抗瘤作用的增强效应。

Objective To investigate the enhanced antitumor effect of cytosine deaminase / 5 fluorocytosine enzyme prodrug system ( CD / 5 FC ) combined with uracil phosphoribosyl transferase ( UPRT ) gene therapy on gastric cancer xenografts in 615 mice .

目的：使用胞嘧啶脱氨酶（cytosinedeaminase，CD）基因/5-氟胞嘧啶（5&fluorocytosine，5-FC）联合放疗治疗裸鼠宫颈癌移植瘤，观察CD/5-FC基因治疗与放疗之间是否具有协同作用。

Objective : This study is aimed to observe the effect of combining cytosinedeaminase ( CD ) / 5-fluorocytosine ( 5-FC ) gene therapy with radiotherapy on cervical carcinoma in nude mouse and to observe if there is a synergistic effect between the two therapies .

目的：研究腺病毒介导的大肠杆菌胞嘧啶脱氨酶基因（AdCMVCD）/5氟胞嘧啶（5FC）自杀基因治疗口腔鳞癌的作用机制。

Objective : To study the therapeutic mechanism of adenovirus mediated cytosine deaminase / 5-fluorocytosine ( AdCMVCD / 5-FC ) suicide gene system in the treatment of oral squamous carcinoma cells in vitro .

目的：克隆酵母菌胞嘧啶脱氨酶（YCD）基因，观察YCD/5氟胞嘧啶（YCD/5-FC）系统对转基因肿瘤细胞的杀伤效应。

Objective : To clone the yeast cytosine deaminase ( YCD ) gene and to elucidate the killing efficacy of yeast cytosine deaminase / 5 - fluorocytosine gene therapy system on gene - transfered cells .