核苷酸链

作者据此提出了倍半萜类抗癌剂的两个亲电活性基团分别与RNA或DNA的双股核苷酸链上的碱基发生电荷转移络合的抗癌机理。

It is postulated that this charge transfer complexing between the two electrophilic groups in sesquiterpenoids and the bases in double helix of DNA or / and RNA may contribute to the antitumor mechanism of this class of compounds .

目前发现的这个酶被命名为FAN1，它是一种核酸酶，能够切割开DNA的核苷酸链。

The enzyme , which they named FAN1 , appears to be a nuclease , which is capable of slicing through strands of DNA .

1953年Watson和Crick提出了DNA的双螺旋结构模型：DNA分子由两条多核苷酸链组成，这两条核苷酸链通过碱基的互补配对相互缠绕形成一种双螺旋结构；

Watson and Crick advanced the double helix structure model of the DNA in 1953 . The DNA is made up of two pieces of nucleotide chains , which is double helix structure with complementary pairing of the bases and winding each other .

使用反义核苷酸链安慰剂不会引起脂蛋白水平和氧化参数的改变。

There was no effect of the control antisense oligonucleotide on lipoprotein levels or oxidative parameters .

CpG寡脱氧核苷酸长链DNA的克隆及重组质粒载体的构建

Cloning and construction of recombinant plasmids containing long strand CpG oligodeoxynucleotides DNA

在设计的靶序列5′端开始的19个核苷酸为正义链，中间加入9个核苷酸TTCAAGAGA的间隔以形成发夹结构，3′端加有转录终止信号TTTTTT。

The sense strand of siRNA was composed of the start 19 nucleotides of the 5 ' end of target sequence .

在哺乳动物细胞里，RNAi可以由21￣25个核苷酸长度的双链小干扰RNA（siRNA）触发。

In mammalian cells , RNAi can be triggered by 21 ￣ 25 nucleotide duplexes of small interfering RNA ( siRNA ) .

病毒无囊膜，直径40nm～45nm，有3种～4种衣壳蛋白，基因组为约5000对核苷酸组成的双链闭合环状DNA。

They are oncogenic DNA virus with icosahedral capsids 40 nm ~ 45 nm in diameter , containing three to four viral proteins and double strand , covalently closed , circular genomes approximately 5 000 bp in size .

结论在体外，K+、Na+可诱导含端粒重复序列的核苷酸形成鸟嘌呤四链体结构。

[ Conclusion ] Both K + and Na + are able to induce the oligonucleotides containing telomeric repeats to form G-quadruplex structure in vitro .