核苷酸链
- 网络Nucleotide Chain
![核苷酸链](../cache/1190546.jpg)
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作者据此提出了倍半萜类抗癌剂的两个亲电活性基团分别与RNA或DNA的双股核苷酸链上的碱基发生电荷转移络合的抗癌机理。
It is postulated that this charge transfer complexing between the two electrophilic groups in sesquiterpenoids and the bases in double helix of DNA or / and RNA may contribute to the antitumor mechanism of this class of compounds .
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目前发现的这个酶被命名为FAN1,它是一种核酸酶,能够切割开DNA的核苷酸链。
The enzyme , which they named FAN1 , appears to be a nuclease , which is capable of slicing through strands of DNA .
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1953年Watson和Crick提出了DNA的双螺旋结构模型:DNA分子由两条多核苷酸链组成,这两条核苷酸链通过碱基的互补配对相互缠绕形成一种双螺旋结构;
Watson and Crick advanced the double helix structure model of the DNA in 1953 . The DNA is made up of two pieces of nucleotide chains , which is double helix structure with complementary pairing of the bases and winding each other .
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使用反义核苷酸链安慰剂不会引起脂蛋白水平和氧化参数的改变。
There was no effect of the control antisense oligonucleotide on lipoprotein levels or oxidative parameters .
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CpG寡脱氧核苷酸长链DNA的克隆及重组质粒载体的构建
Cloning and construction of recombinant plasmids containing long strand CpG oligodeoxynucleotides DNA
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在设计的靶序列5′端开始的19个核苷酸为正义链,中间加入9个核苷酸TTCAAGAGA的间隔以形成发夹结构,3′端加有转录终止信号TTTTTT。
The sense strand of siRNA was composed of the start 19 nucleotides of the 5 ' end of target sequence .
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在哺乳动物细胞里,RNAi可以由21 ̄25个核苷酸长度的双链小干扰RNA(siRNA)触发。
In mammalian cells , RNAi can be triggered by 21  ̄ 25 nucleotide duplexes of small interfering RNA ( siRNA ) .
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病毒无囊膜,直径40nm~45nm,有3种~4种衣壳蛋白,基因组为约5000对核苷酸组成的双链闭合环状DNA。
They are oncogenic DNA virus with icosahedral capsids 40 nm ~ 45 nm in diameter , containing three to four viral proteins and double strand , covalently closed , circular genomes approximately 5 000 bp in size .
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结论在体外,K+、Na+可诱导含端粒重复序列的核苷酸形成鸟嘌呤四链体结构。
[ Conclusion ] Both K + and Na + are able to induce the oligonucleotides containing telomeric repeats to form G-quadruplex structure in vitro .