核苷激酶

人体胸腺嘧啶核苷激酶不完全cDNA的分离、结构分析和表达

Isolation , Preliminary Characterization and Expression of a Near Full-length cDNA for Human Thymidine Kinase

目的：研究转移抑制基因nm23表达产物二磷酸核苷激酶（NDPK）在人肺癌中的表达及意义。

Purpose To study expression and significance of the metastasis suppressor gene nm23 / NDPK in human lung carcinoma .

分别于伤前、伤后6,12,24,48和72h处死动物，检测肠黏膜蛋白质含量、胸腺嘧啶核苷激酶活性、增生指数及PCNA表达。

Protein content , thy-midine kinase activity , proliferative index and PCNA expres-sion in the intestinal mucosa were analyzed at 0 , 6 , 12 , 24,48 , and 72 PBH respectively .

目的研究单纯疱疹病毒胸腺嘧啶核苷激酶/更昔洛韦（Herpessimplexvirusthymidinekinase/gancyclovir，HSVtK/GCV）自杀基因系统对视网膜母细胞瘤（retinoblastoma，Rb）细胞的体外杀伤作用以及旁观者效应发生的机制。

Objective To investigate the killing effect of herpes simplex virus thymidine kinase / gancyclovir ( HSV tk / GCV ) suicide gene therapy system on retinoblastoma ( Rb ) cells and the mechanism of bystander effect .

目的：了解二氢嘧啶脱氢酶（DPD）和胸腺嘧啶核苷激酶（TK）的研究现状和在临床肿瘤治疗中的意义。

OBJECTIVE : To provide the advances of the research in dihydropyrimidine dehydrogenase ( DPD ) and thymidine kinase ( TK ) and the significances of their applications in clinical tumor chemotherapy .

目的建立一种灵敏、特异检测血清中二磷酸核苷激酶（NDPK-A）含量的酶联免疫吸附试验（ELISA）法和试剂盒，分析血清中的NDPK-A含量与血液病之间的关系。

Objective To establish a sensitive and a specific ELISA kit for detecting and analysing serum NDPK-A and to explore the relationship between serum NDPK-A content and hemopathy .

广-9株的胸腺嘧啶核苷激酶（TK）基因既作为表达载体与痘苗病毒基因组体内重组的同源顺序，又作为重组病毒的筛选标记。

The thymidine kinase ( TK ) gene of Guang-9 in the vector provided not only the homologous sequences for in rive recombination with the vaccinia virus genome , but a so the selective marker for the virus recombinants .

目的：构建含有单纯疱疹病毒胸腺嘧啶核苷激酶（HSV-tk）和增强绿色荧光蛋白（EGFP）的重组腺病毒载体，体外转染鼠内皮细胞，并检测其表达。

Objective : To construct a recombinant adenovirus vector carrying gene of herps simplex virus thymidine kinase ( HSV-tk ) and enhanced green fluorescent protein ( EGFP ), and detect its expression in rat endothelial cells .

血清胸腺嘧啶核苷激酶的检测及临床意义

Clinical significance and development of thymidine kinase measurement in serum using anti-TK_1Ab

胸腺嘧啶核苷激酶/丙氧鸟苷自杀基因系统旁观者效应机制的探讨

The mechanism of bystander effect in herpes simplex virus thymidine kinase / ganciclovir mediated gene therapy

二磷酸核苷激酶在膀胱癌中的表达

Nucleoside diphosphate kinase in bladder carcinoma

二氢嘧啶脱氢酶和胸腺嘧啶核苷激酶的研究进展

Advance in dihydropyrimidine dehydrogenase and thymidine kinase influencing on the clinical therapy of pyrimidine chemotherapy drugs

目的了解核苷二磷酸激酶A亚基（NDPKA）能否提高顺铂的抗癌效果。

AIM To explore if nucleoside diphosphate kinase A ( NDPK-A ) can potentiate the antitumor action of cisplatin .

中试规模生产重组人核苷二磷酸激酶A（rhNDPK-A）。

Production of recombinant human nucleoside diphosphate kinase A ( rhNDPK-A ) in pilot-scale .

为探讨核苷二磷酸激酶／nm23（NDPK／nm23）在胆囊、胆管癌中的表达及临床意义，用免疫组化ABC法对41例胆囊癌、12例胆管癌NDPK／nm23表达进行了测定。

To explore the expression and clinical significance of DNPK / nm23 in gallbladder carcinomas and bile duct carcinomas , we examined 41 gallbladder carcinomas and 12 bile duct carcinomas with immunohistochemical ABC method .

至少有7个miRNA家族参与NADPH-细胞色素P450还原酶、核苷二磷酸激酶、超氧歧化酶等过程和调控代谢及胁迫反应中必须蛋白质的形成，表明miRNA在这些过程中扮演极为重要的角色。

At least 7 of 11 miRNA families target NADPH-cytochrome P450 reductase , nucleoside diphosphate kinase , superoxide dismutase , etc. , proteins that are necessary in metabolism and stress response , suggesting that miRNAs play an important role in these processes .

人重组核苷二磷酸激酶α亚基对MCF-7/S的影响

Effect of recombination human nucleoside diphosphate kinase on MCF-7 / S

43个蛋白质中有4个表达量变化显著的被成功鉴定，分别为钴胺素生物合成蛋白、肽基脯氨酰顺反异构酶、核苷二磷酸激酶和N-乙酰-γ-谷氨酰磷酸脱氢酶。

Four proteins of cobalamin biosynthesis protein , N-acetyl-gamma-glutamyl-phosphate reductase , peptidyl prolyl cis-trans isomerase and nucleoside diphosphate kinase were successfully identified .