染料木素

染料木素化学修饰物的合成及其生理活性研究

Synthesis and Biological Activities of Genistein Chemically Modified Compounds

因此，有效增加和补充染料木素的摄取量，被认为是通过饮食调整和改善糖尿病症状的途径之一。

Therefore , the effectively increasing and supplement intake of genistein , are considered one of the ways to improve the symptoms of diabetes by dietary modification .

发酵大豆食品中染料木素含量的ELISA测定

ELISA Study on Genistein Content in Fermented Soybean Food

RP-HPLC法测定怀槐中染料木素和芒柄花黄素含量

RP-HPLC determination of genistein and formononetin in various parts of Maackia amurensis

蛋黄和肌肉等样品中大豆黄酮和染料木素的反相高效液相色谱（RP-HPLC）法的检测

Determination of Daidzein and Genistein in Different Bio-samples by RP-HPLC

大豆黄酮和染料木素对奶牛血清生化及血液流变学指标的影响超敏C反应蛋白与血清酶学在新生儿缺血缺氧性脑病中的变化

Effects of different level of daidzein and genistein on biochemical and hemorheological parameters of dairy cow Variation of Serum hs-CRP and sero-enzyme Levels in Newborns with Hypoxic-ischemic Encephalopathy

RP-HPLC法测定大豆提取物中大豆苷元、染料木素、大豆苷、染料木苷的含量

RP-HPLC determination of daidzein , genistein , daidzin and genistin in soybean extract

目的：用小鼠淋巴瘤细胞TK基因突变试验检测染料木素的诱变性。

Objective : To detect and evaluate the TK gene mutation induced by genistein .

染料木素对人胃癌细胞BGC-823的实验研究

In Vitro Effect of Genistein on Gastric Cancer Cell Line BGC-823

染料木素与大豆甙元对子宫内膜癌细胞株ERRα的影响

Influence of Genistein and Daidzein on estrogen-related receptor - α in an endometrial carcinoma cell line

结果染料木素可抑制去卵巢模型大鼠的体质量增加，使模型大鼠的血清Ca、Mg、P、CT水平明显升高，BGP、ALP水平降低，与正常对照组有显著差异；

RESULTS Genistein could restrain body weight , increase the levels of serum Ca , Mg , P , CT and decrease the levels of BGP and ALP significantly .

抗肿瘤：染料木素对人体鼻炎癌（KB）细胞有细胞毒活性。

Aati-tumors : The dye lignin has the cytotoxin activeness to the human boby rhinitis cancer ( KB ) cell .

目的研究染料木素（Gen）对人前列腺癌细胞（PC-3）的影响。

Objective To study the influence of Genistein on the growth of prostate carcinoma PC-3 cells in vitro .

目的：观察大豆异黄酮中主要成分染料木素（genistein，G）、大豆苷元（daidzein，D）及其苷对于去卵巢大鼠脂质代谢的影响。

AIM : To observe the effects of soy isoflavones , daidzein , genistein , and their glycoside derivatives on lipids metabolism abnormality in ovariectomized rats .

摘要利用高效液相色谱法（hplc）对豆制品中的大豆黄素和染料木素的含量进行测定，从而研究豆制品加工中的游离大豆异黄酮分布情况。

HPLC method was used for the determination of soybean isoflavones , including daidzein and glycitein in soybean products and for the investigation of distribution of isoflavones in production process of bean curd .

以染料木素（Genistein）为标准样品，用分光光度法测定了Genistein和大豆苷原（Daidzein）混合标准溶液的异黄酮总浓度。

Based on genistein as reference standard , the isoflavones content of standard mixture of genistein and daidzein was determined by ultraviolet spectrophotometry .

目的：观察染料木素（GST）和17β雌二醇（E2）对生殖系统的不同影响。

AIM : To investigate the effects of genistein ( GST ) and 17 β estradiol ( E2 ) on the reproductive system in ovariectomized rats .

应用MTT法、3H-TdR掺入法及流式细胞术，研究了两种主要的大豆异黄酮枣大豆黄酮和染料木素对乳腺癌细胞增殖的抑制效应，并探讨了其作用机理。

To study the mechanism of growth inhibition of rat breast carcinoma cells by soybean isoflavones , cancer cell line was treated invitro with daidzein and genistein .

研究显示Rg1和染料木素具有神经保护作用，但其详细作用机制目前尚不清楚。

Both of them are known phytoestrogens and have neuroprotective effects on the nervous system , but the detail mechanism is not very clear .

结论：异黄酮类化合物染料木素、大豆甙元和黄豆黄素均具有诱导PC-3细胞凋亡的作用，这一结果提示，该类物质是可通过诱导细胞凋亡而发挥其抗肿瘤作用的。

Conclusion : Isoflavones could induce apoptosis in prostate cancer cells PC-3 and it may be the main cause of their role in cancer inhibition .

目的研究染料木素（genistein）对6-OHDA制备的帕金森病（PD）模型去卵巢（OVX）大鼠黑质（SN）多巴胺能神经元、铁含量及Bcl-2蛋白表达的影响。

Objective To investigate the effect of genistein on dopaminergic neurons , iron contents and Bcl-2 protein expression of substantia nigra ( SN ) in 6-OHDA-induced PD model of ovariectomized female rats .

结果：随染毒剂量的增加，染料木素对L5178Y的细胞毒性增大。

Results : Cytotoxicity of genistein for L5178Y cells increased dose-dependently .

而在发酵大豆制品中，由于酶的作用，部分黄豆苷和染料木素转化成黄豆苷原（daidzein）和染料木因（genistein），因此，游离态的异黄酮比例增加。

In fermented soy products , due to enzyme 's function , part of daidzin and genistin converted into daidzein and genistein , therefore the proportion of free form of isoflavones increased ;

应用~3H-TdR掺入法和MTT法，研究了大豆黄酮、染料木素和雌激素对SHZ-88细胞体外增殖的影响。

3H-TdR incorporation and microculture tetrazolium ( MTT ) assay were used to study the effects of daidzein , genistein and estrogen on cell proliferation .

染料木素是表皮生长因子受体酪氨酸激酶结构域（EGFR-TK）高度特异的非竞争性抑制剂。

Genistein is a high specific and noncompetitive inhibitor of epidermal growth factor receptor tyramine kinase domain ( EGFR-TK ) .

目的探讨3'-羟基染料木素对3T3-L1前脂肪细胞增殖、分化的影响及其机制。

Objective To explore the effects of3 ' - hydroxygenistein on the proliferation and differentiation of3T3-L1 preadipocytes and to elucidate the related mechanism .

Helferich称，由于染料木素仅仅是大豆成分之一，对纯化的染料木素的研究可能会导致对饮食中大豆的健康意义的误解。

But genistein is only one component of soy , Helferich said , and studying its effects in purified form may lead to misleading conclusions about the health consequences of soy in the diet .

方法：不加S9活化的条件下，用染料木素5、10、15、20μg/ml处理L5178Y细胞3h，采用微孔板法进行细胞毒性、平板接种效率和突变频率测定。

Methods : L5178Y mouse lymphoma cells were exposed to genistein at concentrations 5,10,15 and 20 μ g / ml for 3 hours without S9 metabolic activation . Determination of cytotoxicity , plating efficiency and mutant frequency were performed by using the microwell method .

通过室外盆栽试验，考查秸秆、吸胀萌动温度、处理液（清水、DHG、DHG粗提液、染料木素）三因素对大豆双共生系统的影响及效应。

Through the outdoor pot experiment , examine the straw , imbibed germinating temperature , processing liquid ( water , DHG , DHG crude extract , pure genistein ) three factors on soybean symbiotic system of double and effect .

结果①尼尔雌醇和染料木素中剂量组可抑制动物体重的增长，也可使左股骨重、左胫骨长和左胫骨重明显增加（P001或P005）；

Results 1.Nilestriol and GEN of medium dose could slow the weight of rats and increase the weight of left femur , left tibia and the length of left tibia significantly ( P 0 05 or P 0 01 );