昆明鼠

目的观察弓形虫AH株感染早孕的昆明鼠对其胚胎发育的影响。

Objective To observe the influence of acute Toxoplasma infection on prenatal development in early pregnant KM mouse .

柯萨奇B4和B（3M）病毒重叠感染对低硒昆明鼠T细胞亚群的影响

Effect of superposition infection of CVB_4 and CVB_ ( 3m ) on T cell subgroups of Kunming mice with deficiency of Se

体内实验通过免疫昆明鼠检测了多肽的抗病毒活性，结果表明多肽M、N在小鼠体内起到了一定的中和病毒的作用。

The immunized Kunming mice were used to detect the anti-viral activity of peptides in vivo . The results showed that the peptide M and N could neutralize viral infection activity .

方法：125I标记抗Pgp/抗CD3微型双功能抗体采用氯胺T法，并采用昆明鼠和人K562耐药裸鼠移植瘤模型分别测定该微型双功能抗体在小鼠体内的药代动力学和体内组织分布；

Methods : The pharmacokinetics and distribution of the antibody were analyzed by Kunming mouse and human K562 drug resistance nude mouse xenograft model .

通过建立昆明鼠S180肉瘤模型，探讨了EEF对肿瘤生长、荷瘤鼠生存天数、荷瘤鼠免疫功能及肿瘤凋亡相关基因bax、bcl-2表达的影响；

The effects of EEF on tumor growth , survival days , immune function and the expression of apoptosis-associated genes bax , bcl-2 of tumor-bearing mice were determined through S_ ( 180 ) tumor model .

纯化的vMIPⅡ经尾静脉给药异体皮肤移植小鼠（昆明鼠/Balb/c）连续14d。

Purified vMIP ⅱ was injected in tail vein once everyday after skin transplantation ( Kunming mice to Balb / c ) till the 14th day .

结果表明：副猪嗜血杆菌全菌灭活苗和OMP免疫抗原对昆明鼠均有较强的免疫原性，首免后7天可检测到OMP阳性抗体。

The results showed that : The whole-cell of Haemophilus parasuis vaccine and OMP vaccine have a strong immunogenicity in Kunming mice . After 7 days , the positive antibody of OMP can be detected firstly .

昆明鼠口服2×109CFU突变菌株O139后仍然健活，无不良反应，说明该菌对小鼠安全。

The mice was live and had no untoward reaction after drenched 2 × 109CFU mutant strain , it indicated that the strain was safe for mice .

方法：本实验体外以不同剂量IFN－γ单独或与TNF－α联合刺激昆明鼠腹腔巨噬细胞，观察其对入侵的RH株速殖子的作用及培养上清中NO的水平。

METHODS : The in vitro effect of cultivated mouse peritoneal macrophages activated by IFN γ alone or IFN γ combined with different doses of TNF α on the intracellular tachyzoites of RH strains and the nitric oxide ( NO ) level in the culture medium supernatant were simultaneously determined .

实验组小鼠淋巴细胞对供者淋巴细胞刺激的反应性均下降（P<0.01），以接受致敏DLI者最明显，而对昆明鼠淋巴细胞刺激的反应性维持正常水平。

The lymphocyte responses of the mice in experimental group to donor lymphocyte stimulation were decreased , more obviously in the recipient mice with sensitized DLI , and those to Kunming mice lymphocyte stimulation was maintained at a normal level in each group .

昆明鼠体内卵母细胞的戊巴比妥钠激活和发育

Parthenogenetic Activation and Development of Kunming mouse oocytes in Vivo with Pentobarbital Sodium

中国昆明鼠蛋白质及同工酶多态性的研究

Studies on the Polymorphism of the Protein and Isoenzymes in KM ( Kunming ) Mice

目的探讨丁香酚不同途径给药对昆明鼠的空间学习记忆的影响。

Objective To study the effects learning and memory on Kunming mice through different medication of eugenol .

自发激活率分别为13.3%和46.0%，C57BL/6系小鼠显著低于昆明鼠。

Spontaneous activation rates were respectively 13.3 % and 46.0 % , C57BL / 6 were obviously lower than Kunming mouse .

以此判据成功地检验到实验获得的昆明鼠发光光子图像中的信号。

With this judge , we have succeed in finding signal in the image of ultra-weak bioluminescence emitted by a living Kunming mouse .

昆明鼠物体识别模型具有简单、快速、可靠等特点，可以在安全药理学研究中用来检测化学药物对记忆的损伤。

The object recognition task in KM mice , which is simple , rapid , and reliable , should be of great use in safety pharmacology to detect amnesic properties of new compounds .

方法用弓形虫AH株感染雌性性成熟昆明小白鼠，同时设对照组。

( Methods ) Small white sex-mature KM mice were infected with toxoplasma AH strain , and the control group was set up at the same time .

根据改良寇氏法进行毒理学实验，用昆明小白鼠腹腔注射急性毒性实验，测得30%硼葡萄糖酸钙注射液的半数致死量（LD（50））为了.77g/kg体重。

Doing the acute toxicological experiment with KunMing mice according to the improving Kou 's methods by injecting 30 % Boric acid glucal into abdominal cavity of mice , We gained LD50 of the injection is 7.77g/kg body weight ;

方法采用显微注射法，将人bcl-xL基因注入昆明小白鼠受精卵获得子代鼠，然后作PCR、Southern-blot、mRNA、Western-blot检测以获得阳性鼠。

Methods Bcl xL gene was introduced into mice by microinjection . The presence of bcl xL and its expression were confirmed by PCR , Southern blot , mRNA inspection , Western blot in the founders .

动物及细胞系：清洁级孕12.5天的昆明小白鼠1只，实验过程中对动物的处置符合动物伦理学标准；小鼠胚胎干细胞系129X/SvJ由美国ATCC提供。

Animal and cell line : One depuratory grade Kunming Mus musculus albus pregnant for 12.5d . The disposition of the animal was accord with the ethical standard .

为探索精原干细胞（SpermatogonialStemcells，SSCs）体外自增殖的条件以及SSCs体外快速扩增的方法，以6-8日龄昆明乳鼠为材料，分离小鼠睾丸细胞，采用Percoll梯度离心法富集SSCs；

This study investigated conditions and methods for the in vitro proliferation of spermatogonial stem cells ( SSCs ) . Germ cells were isolated from testes of KM mice aged 6-8 days , and were enriched using Percoll grads centrifugation ;

方法1、对6-8W龄昆明小白鼠促排卵，处死小鼠后获得小鼠初级囊胚和扩张囊胚。

Methed 1 . To promote 6-8W small mouse ovulate and obtain early blastocysts and expanded blastocysts .

使用该系统在昆明小白鼠进行肿瘤治疗实验。

We experiment tumor therapy of the Kunming small white rats .

昆明胚鼠生殖腺发育的形态学观察

Morphological studies on embryonic gonad development in Kunming mice

该乳酸菌菌株对50只昆明小白鼠的急性毒性试验表明，该乳酸菌菌株对动物机体无急性毒性作用。

It suggested that the isolated Lactobacillus strains were no acute toxicity to the animal body from the acute toxicity test of the isolated Lactobacillus strains to 50 small Kunming white mice .

复方益孕液的抗炎试验以昆明小白鼠为试验动物，给小白鼠腹腔注射复方益孕液，观察其对二甲苯所致的小鼠耳廓肿胀的抑制程度。

The anti-inflammatory test of " beneficial pregnancy liquid " The Kunming mice as test animals , the inhibition effect of beneficial pregnancy liquid to mice ear edema caused by xylene was observed .

选用40只昆明小白鼠，雌雄各半，随机分成4组：低钙膳食组、碳酸钙组、鳗骨粉组和高钙鳗骨粉组。

Forty Kunming rats , male and female in half , are randomly divided into four groups ( low calcium meal , calcium carbonate , bone powder of Anguilla japonica , high calcium bone powder of Anguilla japonica ) .

方法用昆明小白鼠进行扭体试验、抗巴豆油致炎试验和游泳能力试验，检测I号药的镇痛、消炎和增强体能的效应。

Methods Kunming mice were applied to the body turning test , anti croton oil induced inflammation test , and swimming ability test , for examining the effectiveness of FHI on analgesia , anti inflammation , and enhancement of physical ability .

方法：实验于2004-03/2005-01在中山大学药物开发中心药理实验室完成。①选用健康昆明小白鼠240只，雄性，6周龄。

METHODS : The experiment was conducted in the Central Pharmacological Laboratory of Center for Medicine Development in Sun Yat-Sen University between March 2004 to January 2005 . ① 240 healthy male Kunming white mice , aged 6 months were selected .

方法：实验于1998-03/2000-07在中国科学院动物研究所生物膜与膜生物国家重点实验室完成。雄性昆明小白鼠32只，随机分为4组，每组8只。

METHODS : This experiment was completed in State Key Laboratory of Biomembrane and Membrane Biotechnology of Institute of Zoology , Chinese Academy of Sciences from March 1998 to July 2000 . A total of 32 male Kunming mice were divided into four groups , each containing 8 mice .