手性催化剂

固载的手性催化剂在不对称Aldol反应中的应用

The Application of Immobilized Chiral Catalysts in the Asymmetric Aldol Reactions

CBS催化剂是重要的手性催化剂，用于不对称还原前手性酮，催化反应收率与光学收率均很高。

CBS catalyst is one kind of the important chiral catalysts in asymmetric reductions of prochiral ketones , which have extremely high yield and optical yield .

我们全面的考查了手性催化剂、温度、溶剂和底物浓度对该Michael加成反应的影响。

The effects of chiral catalyst , temperature , solvent , concentration of the reaction on the Michael addition were investigated .

以SBA-15介孔分子筛为载体制备了Fe（Ⅲ）-壳聚糖（CS）络合物为活性组分的多相手性催化剂（Fe-CS/SBA-15）。

A heterogeneous chiral catalyst Fe (ⅲ) - chitosan ( CS ) complex / mesoporous molecular sieve SBA-15 ( Fe-CS / SBA-15 ) was prepared .

催化乙醛酸酯-烯反应（glyoxylate-enereaction）合成具有光学活性的α-羟基酯需要运用手性催化剂。

The asymmetric catalysis of glyoxylate-ene reaction is one of the most important methods for preparation of optical-purity α - hydroxy esters , which is a building block in organic synthesis .

CBS催化剂是不对称还原反应中重要的手性催化剂，广泛应用于不对称合成领域中极重要的手性配体与手性中间体以及生物活性物质和天然物质的合成，具有巨大的市场潜力。

CBS catalysts , as important chiral catalysts for asymmetric reduction , are widely used in asymmetric synthesis such as synthesis of chiral ligands , chiral intermediates , biologically-active ( materials ) and natural substance .

光学纯的2，2′-二羟基-1，1′-联萘（BINOL）及其衍生物是典型的轴不对称化合物，它们作为手性催化剂配体广泛地应用于均相不对称催化氢化中。

Optically pure 2,2 ' - dihydroxy-1,1 ' - binaphthyl ( BINOL ) and its derivatives are classical axially chiral ligand which used extensively in homogeneous asymmetric catalytic hydrogenation .

高分子手性催化剂在不对称合成应用中的新进展

Recent Development of Polymer supported Chiral Catalysts used in Asymmetric Synthesis

多相手性催化剂的制备及其对不对称加氢反应的催化作用

Preparation of heterogeneous chiral catalysts and their application to asymmetric hydrogenation

高分子载体手性催化剂在不对称碳碳键形成中的应用

Polymer-supported Chiral Catalysts in Asymmetric C & C Bond Forming Reactions

手性催化剂负载的一种新方法：自负载策略

A New Method for Chiral Catalyst Immobilization : Self - Supporting Strategy

聚合物负载的手性催化剂和手性试剂的合成及应用

The Synthesis and Applications of Polymer - Supported Chiral Catalysts and Reagents

摘要脂肪酶是不对称合成中一种常用的手性催化剂。

Lipase are used frequently as chiral catalysts in the asymmetrization processes .

结合自己的研究对这一领域的不对称催化反应及手性催化剂的发展进行了归纳总结。

A review of these asymmetric reactions with the catalysis of chiral catalysts is presented .

本文评述了修饰型多相手性催化剂在不对称合成中的应用。

The application of modified heterogeneous chiral catalysts in asymmetric synthesis is described in this review .

手性催化剂与不对称反应

Chiral catalyst and asymmetric reaction

在不对称催化氢化过程中起关键作用的是手性催化剂的结构，包括手性膦配体和中心过渡金属。

The paper reviewed the study on the chiral phosphines in asymmetric catalytic hydrogenation and their nearest development .

本课题所研究的是含有多聚苯刚性分子片段的金鸡纳碱类手性催化剂。

This paper focuses on the synthesis of cinchona alkaloid catalysts which contains rigid polybenzene moieties and their application in asymmetric catalytic reactions .

寻求高效的手性催化剂，实现烃类在常温常压下的不对称催化氧化是一个世界性难题。

Seeking highly effective chiral catalysts to catalyze asymmetric oxidation of hydrocarbons under normal pressure and room temperature is one of the global problems .

纳米簇合物作为新催化材料，可望将均相催化和多相催化的优势结合起来，发展新的手性催化剂，因此越来越受到重视。

The nanoclusters , which are new catalytic materials , are expected to be able to combine the merits of both homogeneous and heterogeneous hydrogenation .

本文综述了近年来用微生物和金属手性催化剂催化氢化β-酮酯的基础研究进展。

The progress of fundamental research of hydrogenation of β - keto ester by microbiological catalyst and metal chiral catalyst in recent years are reviewed .

通过这些模型，可以预测新催化剂与新反应条件下的催化效果，指导手性催化剂的设计，优化反应环境，对已出提机理的部分反应，构效关系模型还能够对其进行适当的验证。

Those models are useful to screen new asymmetric catalysts , to instruct the design of reaction environment , and to testify or improve the existing mechanism .

恶唑啉和恶唑啉的衍生物具有非常广泛的用途，特别作为手性催化剂配体，被广泛应用于不对称合成领域。

Oxazoline and its derivatives have a wide range of application , especially the oxazoline as chiral catalysts ligand are widely used in the field of asymmetric synthesis .

不对称催化合成的核心问题是具有高对映选择性和催化活性的手性催化剂的设计与合成。

The design and synthesis of new chiral catalyst with high reactivity as well as excellent enantioselectivity have played a significant role in the development of the asymmetric catalytic reactions .

其中，新型手性催化剂的设计与合成具有非常重要的意义，直接影响到对反应的不对称诱导和控制。

In this area , the design and synthesis of novel chiral catalyst has a very important meaning , since it directly affect the asymmetric induction and control of the reaction .

但由于手性催化剂的合成困难，价格昂贵，限制了其发展，因此，如果实现催化剂的回收利用，将会使这个问题得到缓解。

However , it is limited by the difficulty in synthesizing and the high price of the chiral catalysts . so , the problem will be resolved if the catalyst can be recycled .

寻求高效稳定的手性催化剂的关键在于设计和寻找理想的手性基团和具有良好拓扑学性质的金属卟啉结构。

To get the highly efficient and stable chiral catalysts , it should be mentioned that the key step is to design and synthesis of the ideal chiral groups and metalloporphyrins with good topological optimization structure .

总结了不对称催化加氢技术中手性催化剂的制备、催化机理以及催化工艺的研究熏未来不对称催化对加氢技术的发展趋势提出了一些看法。

The development of the preparation of chiral catalysts , the catalytic mechanism and the process in the asymmetric catalytic hydrogenation ( ACH ) are summarized . The views on the trends in the ACH are put forward .

由此可以看出，这类催化剂不仅保留了小分子手性催化剂催化不对称反应优异的催化效果，而且实现了手性催化剂的回收再利用。

In this way , we can easily see that these catalysts not only retained the excellent catalytic effect of small molecular chiral catalyst , but also achieved the aim of recovering and recycling of the chiral catalysts .

根据反应类型，综述了近年新发现的用于不对称碳碳键形成中的具有较好催化活性和立体选择性的高分子载体手性催化剂及制备方法。

In this review , we summarized , according to the type of reactions , the very recently discovered polymer-supported chiral catalysts , which showed good catalytic activity and enantioselectivity in asymmetric C & C bond forming reactions and prepared method .