甲二醇

亚甲二醇二硝酸酯构型和电子结构的ABINITIO研究

Ab Initio Study of the Conformations and Electronic Structures of Methylene Glycol Dinitrate

亚甲二醇二硝酸酯的构象和热解机理的理论研究

Theoretical Study of Conformation and Thermolysis Mechanism of Methylene Glycol Dinitrate

酸性反应阶段以缩聚反应为主，形成以亚甲基键或醚键联接大分子体系，聚合状态的甲醛已全部分解，并以甲二醇的形式参与缩聚反应；

At the acid reaction stage the polycondensation reaction was primary and formed the macro-molecule system with the methylene or the ether linkage , and the polymerization formaldehyde decomposed completely , and as the form of methylene glycol participated in condensation reaction .

核因子κB在2-甲氧雌二醇诱导骨尤文氏肉瘤细胞凋亡中的作用研究

The Role of Nuclear Factor - κ B in 2-Methoxyestradiol-induced Apoptosis of Ewing 's Sarcoma Cells

2-甲氧雌二醇（2-ME）是雌激素在体内的正常代谢产物，具有抑制血管生成和抗肿瘤的双重效果。

2-Methoxyestradiol ( 2-ME ) is an endogenous metabolite of estrogen that has both antiangiogenic and antitumor effects .

2-甲氧雌二醇对子宫内膜癌抑制作用的实验研究

Study on the Effect of 2-Methoxyestradiol on Endometrial Carcinoma

2-甲氧基雌二醇诱导K562细胞凋亡及机制研究

Mechanism Underlying 2-methoxyestradiol Inducing Apoptosis of K562 cells

课题组前期研究已成功完成了ADD到雌二醇的合成方法和产业化工艺，本工作进一步以雌二醇为原料合成2-甲氧基雌二醇。

Our research group has already completed the synthesis and industrialization of estradiol from ADD . This work is using estradiol as starting material to synthesize 2-methoxyestradiol .

2-甲氧基雌二醇对白血病细胞K562增生、凋亡及细胞周期的影响

Effect of 2-methoxyestradiol on the proliferation , apoptosis and cell cycle of bcr / abl + K562 cells

2-甲氧基雌二醇作用人白血病细胞株CEM的实验研究及其机制探讨

In Vitro Study of Effect of 2-methoxyestradiol in Human Leukemia Cell Lines CEM and Its Related Mechanism

2-甲氧基雌二醇（2-methoxyestradiol，2-ME2）是一种雌激素的代谢产物，能够在转录后水平抑制HIF-1的活性，其在肿瘤治疗方面的研究已经成为热点。

2-methoxyestradiol ( 2-ME2 ), an estrogen metabolite , can inhibit the post-transcriptional level of HIF-1 , and become a hot spot in research of cancer treatment .

目的：探讨了近年来对多种肿瘤均有治疗效果的2-甲氧基雌二醇（2ME2），一种雌激素的衍生物治疗MM的可行性，并对其作用机制进行了研究。

Objective : We studied the feasibility of 2-methoxyestradiol ( 2ME2 ) , an estrogen derivative on MM , which has special effect on various tumors in recent years , and explored its mechanism on MM .

本研究观察2-甲氧基雌二醇（2ME2）对骨髓瘤细胞是否具有直接的诱导分化作用。

This study was aimed to investigate whether 2-methoxyestradiol ( 2ME2 ) could exert effect of inducing differentiation on myeloma cells .

目的：探讨2-甲氧基雌二醇（2ME2）对多发性骨髓瘤患者骨髓瘤细胞及造血前体细胞凋亡的影响。

Purpose : To explore the in vitro effects of apoptosis induction of 2-methoxyestradiol ( 2ME2 ), an estrogen derivative on primary myeloma cells and hematopoietic precursors from multiple myeloma patients .

2-甲氧基雌二醇静脉乳剂性质及初步安全性评价

Investigation of property and preliminary safety of 2-methoxyestradiol intravenous emulsions

目的合成抗肿瘤新药新生血管形成抑制剂2甲氧基雌二醇。

Purpose To synthesize a new antitumor drug 2-methoxyestradiol which is an angiogenesis inhibitor .

2-甲氧基雌二醇合成方法的改进

An Improved Synthetic Method of 2-Methoxyestradiol

并得到了卡尔·费休试剂配制的电解液中碘、二氧化硫、甲酰胺和乙二醇的最佳浓度范围。

Optimal concentration range of iodine , sulphur dioxide formamide and ethylene glycol in the electrolyte is obtained .

2-甲氧基雌二醇及三氧化二砷对骨髓瘤细胞凋亡相关基因表达谱影响的研究

Investigation of the effect of 2-methoxyestradiol and arsenic trioxide on the apoptosis-associated gene expression profile of myeloma cells

结果改进的合成方法割除了文献报道方法中的3,17双乙酰化及水解二个反应步骤，合成获得的2甲氧基雌二醇成品进行了结构确证。

Results Compared with reported method , two reaction stages ( 3,17-diacetylation and hydrolysis ) were omitted in improved synthesis . The structure of obtained 2-methoxyestradiol was confirmed via 1H ? NMR and mass spectrum .

方法以雌二醇为原料经2位溴代，继而甲氧基化直接合成2甲氧基雌二醇。

Methods 2-methoxyestradiol was directly synthesized by 2-bromination followed methoxylation from estradiol .