甲羟戊酸

用H2O2建立细胞损伤模型，细胞培养前用不同浓度辛伐他汀和甲羟戊酸进行预处理。

The cell injury model was establish by H_ ( 2 ) O_ ( 2 ), and before cell culture different concentrations of simvastatin and mevalonic acid ( MVA ) were used for pre-treatment .

结论缺氧、复氧应激下血管内皮细胞eNOS表达减少，iNOS表达增加；辛伐他汀可以阻止因缺氧、复氧刺激导致的eNOS低表达和iNOS高表达，该作用可被甲羟戊酸逆转。

Conclusion Simvastatin restore eNOS and iNOS expression in cultured endothelial cells during hypoxia-reoxygenation , and mevalonate reverse this effect .

加入HMGCoA下游产物甲羟戊酸可完全逆转这种作用。

Addition of mevalonate , the immediate product of HMG CoA , could completely reverse this effect .

目的探讨甲羟戊酸（MVA）对人类肾小球系膜细胞（HMC）增殖的作用和机制。

Objective To explore the effects and mechanism of mevalonate on proliferation of cultured human glomerular mesangial cells ( HMC ) in vitro .

结论缺氧复氧刺激使ECV304分泌tPA、PAI-1增加；辛伐他汀可减少缺氧复氧应激下血管内皮细胞分泌PAI-1，对tPA无影响，减少PAI-1/tPA比值，该作用可被甲羟戊酸逆转。

Conclusions Simvastatin decreases the influence of hypoxia-reoxygenation on the secretion of tPA and PAI-1 in cultured human endothelial cells , and this effect is reversed by mevalonate .

结论：氟伐他汀抑制AngⅡ和PDGF诱导的高血压大鼠血管平滑肌细胞增殖；甲羟戊酸代谢途径可能参与血管平滑肌细胞增殖过程。

CONCLUSION : The proliferation of ASMCs induced by Ang ⅱ and PDGF was inhibited by fluvastatin , suggesting that mevalonate acid pathway may play an important role in the proliferation of ASMCs .

大戟甲羟戊酸途径关键酶基因hmgr的克隆与分析

Cloning and Analysis of a cDNA Encoding Key Enzyme Gene ( hmgr ) of the MVA Pathway in Medicinal Plant Euphorbia pekinensis

方法：培养自发性高血压大鼠主动脉血管平滑肌细胞，不同浓度的氟伐他汀和甲羟戊酸干预后，进行细胞计数和3H-TdR掺入率的测定。

Methods : The aorta smooth muscle cells ( ASMCs ) of spontaneously hypertensive rats were cultured , and the proliferation of cells were detected by measuring cell number and 3H thymidine ( 3H TdR ) incorporation after treatment with fluvastatin and mevalonate acid .

背景：法呢醇焦磷酸合成酶（FPPS）是甲羟戊酸途径中的一个重要酶，能催化合成异戊二烯中间产物，而后者在小GTP蛋白异戊二烯化过程中不可或缺。

Background : Farnesyl pyrophosphate synthase ( FPPS ), an essential enzyme in the mevalonate pathway , catalyzes the synthesis of isoprenoid intermediates . The latter is needed for isoprenylation of small GTPase .

甲羟戊酸通路在细胞生长中起重要作用。

Mevalonate ( Mev ) pathway plays a role in cell growth .

在肺炎链球菌中，异戊二烯的合成主要采用甲羟戊酸途径。

Streptococcus pneumonia use the mevalonate pathway for the synthesis of IPP .

甲羟戊酸对人类肾小球系膜细胞增殖的影响

Effects of mevalonate on proliferation of cultured human glomerular mesangial cells in vitro

类异戊二烯非甲羟戊酸代谢途径的分子生物学研究进展

Advance on molecular biology of isoprenoids non-mevalonate pathway

目前认为真菌中脱落酸生物合成是经甲羟戊酸、焦磷酸法尼酯的直接合成途径。

It is supposed that abscisic acid in fungi was synthesized by direct pathway through MVA and FPP .

我国自主创新型大学组织转型的途径&以华中科技大学为例自发性高血压大鼠心血管组织中甲羟戊酸途径的研究

Organizational Pathways of Transformation of Chinese Proactive Universities ; Study of Mevalonate Pathway in Cardiovascular System of Spontaneously Hypertensive Rats

以便进一步探讨产生异戊二烯的甲羟戊酸和类异戊二烯代谢通路及其代谢异常在精神分裂症病理生理机制中的作用。

The aim of this study was to explore the role of the mevalonate pathway and the isoprenoid pathway in the pathogenesis of schizophrenia .

甲羟戊酸的代谢产物是真核细胞一系列生物活动的关键，他汀类抑制甲羟戊酸代谢通路后可产生多种效应。

Products of mevalonate metabolism are critical for several celluar processes of eukaryotic cells , and inhibition of the mevalonate pathway by statins has pleiotropic effects .