急性毒性试验

急性毒性试验：ICR小鼠（18一229）随机分为2组，雌雄各半，灌胃给药组以钙纳米粒子2.76吵g灌胃，一日内分两次给药；

The acute toxicity test : Both sexes of ICR mice ( weight 18-22g ) were randomly divided into 2 groups .

急性毒性试验：口服LD（50）

In acute toxicity test , the LD_ ( 50 ) was 1.49ml/kg by intragastric administration and 0.19ml/kg by intravenous administration .

采用体外细胞毒性和体内全身急性毒性试验方法，评价去甲斑蝥素微乳的抗肿瘤活性及其生物安全性。结果微乳平均粒径为（44±9）nm。

Results The mean particle diameter of microemulsion was ( 44 ± 9 ) nm .

产品经小鼠动物急性毒性试验，测得LD（50）为（17.29±1.45）g/kg，表明产品临床使用时是安全的；

Animal trial indicates that clinical use is safe .

TDI的亚急性毒性试验

Sub acute toxicology experiment of TDI

小鼠急性毒性试验表明LD50>8g·kg-1。

Experiment of acute toxicity in mice showed , LD 50 > 8g · kg 1 .

方法对40只SD大鼠和8只新西兰大白兔分别进行急性毒性试验以及皮肤和眼刺激试验。

Methods Forty SD rats and eight New Zealand rabbits were chosen to perform acute toxicity test and skin and eye stimulation experiments , respectively .

为了对抗除草剂基因（BAR）转基因水稻进行安全性评价，对该样品进行了急性毒性试验、致突变试验及30天喂养试验。

In order to evaluate the safety of anti herbicide gene ( BAR ) transgenic rice , acute toxicity experiments , mutation experiments and a 30 day feeding test were conducted .

方法鼠耳肿胀法、小鼠脾淋巴细胞增殖法、小鼠ig急性毒性试验（最大耐受量测定）。

Methods Model of the swelling of mouse ear , lymphocyte proliferation response and acute toxicity test were used .

方法急性毒性试验为小鼠尾静脉注射给药，测定LD50；

Methods LD_ ( 50 ) of acute toxicity was determined by i.v. in mice .

结果：川贝枇杷糖对两种性别小鼠、大鼠经口急性毒性试验，LD50均大于10g/kg，属实际无毒物；

Results : LD50 in rats and mice were more than 10 g / kg ;

另外亚急性毒性试验结果表明该提取物30d喂养对大鼠各项观察指标未产生明显影响。

The result of thirty days feeding study of rats exhibited no obvious toxicity .

方法：根据《食品安全性毒性评价程序》进行小鼠经口急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验。

Methods : Acute toxicity test , Ames test , bone marrow micronucleus test , sperm malformation test were conducted .

非离子态氨对美洲鳗鲡（Anguillarostrata）的急性毒性试验

The toxicity of unionised ammonia to the Anguilla rostrata

大蒜水提取物的小鼠体内急性毒性试验证明该受试物对小鼠的急性毒性LD（50）均大于20g/kg·bw，初步说明该样品无毒。

LD_ ( 50 ) of the extracts of garlic by water was more than 20g / kg · bw and it had no toxicity .

在温度（20±1）℃、盐度22～24‰条件下，对海蜇螅状幼体和碟状幼体进行了pH适应性试验和不同pH下氨氮的急性毒性试验。

The tests for the acute toxicity of ammonia on scyphistoma and ephyra of jellyfish ( Rhopilema esculenta ) are carried out under different pH values at temperature of ( 20 ± 1 )℃ and salinity of 22-24 ‰ .

结果浏阳霉素对两种性别小鼠和大鼠的经口急性毒性试验，LD50均大于5000g/kg；

[ Results ] Its acute oral LD50 in both rats and mice were greater than 5 000 mg / kg .

方法：采用小鼠经口急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验及CHO细胞染色体畸变试验等方法进行检测。

Methods : The studies were conducted with acute toxicity test , Ames test , micronuclei test and chromosome aberration test on CHO cell in vitro .

产后康复宁煎剂对小白鼠急性毒性试验结果，LD（50）为51.286±0.578g/kg。

LD50 of the acute poison test of Chan Hou Kang Fu Ning ( CHKFN ) decoction to experiment of mice was 51 . 286 ± 0 . 578g / kg .

结果：急性毒性试验表明，小鼠灌胃给予富硒益生菌，其LD50为18.49g/kg。

RESULTS : The oral acute toxicity study revealed that the LD50 of selenium-enriched probiotics was 18.49 g / kg in mice .

结果：此天然抗氧化剂经小鼠急性毒性试验，最大耐受剂量大于8g/kg·BW，属无毒物质；

Results : BSB extract was a substance with no toxicity according to the acute toxicity test ( MTD > 8g / kg · BW ) .

急性毒性试验显示：炮姜LD（50）为170.6±1.1g/kg，干姜250g/kg以上未见死亡。

The acute toxicity test has shown that the LD50 of roasted ginger decoction administered orally is 170.6 ± 1.1g / kg , but it is over 250g / kg with dry ginger .

清解注射液对小白鼠急性毒性试验，LD（50）为167.294g/kg；对20%的猪、牛血球混悬液进行了几天观察，无溶血现象。

The results showed that QING - JIE injection had its LD50 as 167 . 294g / kg for mice , and had no hemolysis effect on RBC suspension ( 20 % ) .

头花千金藤急性毒性试验结果表明：其块根鲜品与干品水煎液的LD（50）分别为41.4g/kg和22.9g/kg。

The acute toxicity of Stephania cepharantha was studied , LD50 of aqueous extract of its wet and dry root tuber oral were 41.4 g / kg and 22.9 g / kg respectively .

同时，采用扭体法和热板法实验观察该药对BABL／C小鼠的镇痛效果，并进行急性毒性试验研究。

Meanwhile , the analgesic efficacy of Wenyangzhitong capsule on BABL / C mice was observed by boby-turning and hot plate experiments , combined with the experimental study of acute toxicity .

采用静态急性毒性试验方法，研究了久效磷对黄鳝的鳃、肝脏和肾脏组织中过氧化氢酶（CAT）和Na+，K+-ATP酶活性的影响。

Using a static toxicity experiment method , the effects of monocrotophos ( MCP ) on CAT and Na ~ + , K ~ + - ATPase activities in the gill , liver and kidney of Monopterus albus were studied .

干预：采用可降解PCL的浸出液进行了急性毒性试验、Ames试验、微核试验、肌肉刺激实验、热源试验。

INTERVENTIONS : The extraction solution of degradable PCL was used to conduct acute toxicity testing , Ames test , micronucleus test , muscle stimulation test and heat source test .

方法：通过急性毒性试验观察DMPS和TETS对小鼠的影响；

METHODS : Acute toxicity experiments were conducted to observe the effects of DMPS and TETS on mice .

结果1.（1）全身急性毒性试验：注射72h后，与注射前相比，阴性对照组、CoPP组小鼠体重均呈增长趋势。

After leaching liquor or saline injection 72h , the body weight of mice in CoPP group and negative control group showed an increasing trend .

本文报道了多氯联苯（PCB1254）对斑马鱼（Brachydaniorerio）的亚急性毒性试验及其组织结构的影响。

The sub-acute toxicity test was conducted for PCB 1254 upon the zebrafish ( Brachydanio rerio ) .