应答元件

P53与乙型肝炎病毒增强子Ⅰ上游P53样应答元件结合序列关系研究

Interaction of p53 with p53 Response Element Like Binding Sequence at Upstream of Hepatitis B Virus Enhancer ⅰ

本实验拟观察肝癌细胞中P53蛋白与HBV基因组P53样应答元件结合序列之间的关系。

This study was designed to further investigate the interaction between P53 and p53 response element like binding sequence at upstream of HBV enhancer ⅰ .

雄激素应答元件陷阱DNA诱导前列腺癌细胞LNCaP凋亡

Apoptosis of the human prostate cancer cell line LNCaP induced by ARE decoy DNA

脱水应答元件结合因子（Dehydrationresponsiveelementbindingfactor，DREB）是植物非生物胁迫信号转导最为重要的转录因子之一，与许多抗逆相关基因的表达调节有关。

Dehydration Responsive Element Binding protein ( DREB ) is one of the most important transcription factor which transducts abiotic stress signals at the transcriptional level .

低氧预适应对小鼠海马组织HIF-1与EPO低氧应答元件结合活性的影响

The effect of hypoxia preconditioning no binding activity of HIF-1 on the HRE with EPO in the hippocampus of mice

538~+60区域启动子的调控做了比较全面的分析，着重研究了5′启动子中的血清刺激应答元件以及PCNA在细胞周期DNA损伤检查点（checkpoint）机制中的转录调控。

The serum-responsive element in the PCNA 5 ′ promoter , the transcriptional regulation of PCNA gene in the cell cycle DNA damage checkpoint , were elucidated in detail .

抗体：cAMP应答元件结合蛋白、B淋巴细胞白血病-2基因产物中的Bcl-2、细胞色素C由宣武医院北京脑老化研究实验室制备。

Antibody : Beijing Key Experimental Room in Brain Aging of Xuanwu Hospital prepared cAMP responsive element binding protein ( CREB ), Bcl 2 in B lymphatic leukaemia 2 genetic product and cytochrome C ( CytC ) .

TRs可以单体、同二聚体、异二聚的形式与甲状腺激素应答元件结合，介导甲状腺激素调节靶基因。

TRs can bind to thyroid hormone response elements as monomers , homodimers and heterodimers , which mediate thyroid hormone regulation of target genes .

用PlantCare软件进一步作顺式作用元件分析，发现两段启动子序列包含大量光反应元件及脱落酸、赤霉素、水杨酸、生长素、乙烯等激素应答元件。

After this , we analysised the upstream regulatory elements in the two promoter fragment with software of Plant Care , and found lots of light - responsive element , and abscisic acid-responsive element , auxin - responsive element , ethylene-responsive element , gibberellin-responsive element , salicylic acid-responsive element .

生物信息学分析显示，NGAL5′侧翼-657~-417区段至少存在3个潜在的TPA应答元件，表明有应答TPA刺激的结构基础。

The analysis by bioinformatics showed that there is the structural character responding to TPA induction in the gene and at least 3 putative TPA response elements in-657 ~( - 417 ) position .

根据文献报道的缺氧应答元件（HRE）和人甲胎蛋白（AFP）核心启动子（AF0.3）基因序列，设计并合成2对引物，采用PCR方法从肝癌细胞基因组DNA中扩增获得大小分别约为。

Two pair primers was designed and synthesized according to reported gene sequences of the hypoxia responsive element ( HER ) and human a-fetoprotein ( AFP ) core promoter ( AF0.3 ) .

目的：建立靶向雌激素应答元件（ERE）的药物筛选模型，为筛选雌激素受体（ER）配体奠定基础。

Objective : AIM To establish a drug screening model based on transcriptional regulation of estrogen responsive element ( ERE ) and use it to screen compounds for discovering new ligands of estrogen receptor ( ER ) subtypes .

结果：本研究发现AR的N-端含有一段有抑制功能的片段，它由81个氨基酸组成，位于DBD的上游，该片段能直接与DBD相互作用，抑制DBD与雄激素应答元件的结合。

Results The N terminal of AR contained an inhibitory domain located in an 81-amino acid segment lying upstream of the DNA-binding domain ( DBD ) . The inhibitory domain interacted directly with DBD and repressed DBD binding to the ARE .

近年研究发现，酪氨酸酶主要受小眼畸形相关转录因子（MITF）的调控，而MITF的表达又受到上游蛋白如cAMP应答元件结合蛋白（CREB）的影响。

Recent studies showed that tyrosinase is mainly regulated by microphthalmia-associated transcription factor ( MITF ), which expression is regulated by upstream proteins such as cAMP response element binding protein ( CREB ) .

目的：观察低氧预适应对小鼠海马组织HIF-1与EPO的低氧应答元件（HRE）结合活性的变化，探讨这种变化与低氧预适应形成的关系。

Aim : To observe change of binding activity of HIF-1 with erythropoietin ( EPO ) hypoxia response element ( HRE ) in the hippocampus of mice preconditioned to hypoxia and explore relationship between the changes and the preconditioning .

DREB类的转录因子特异性地与DRE元件（脱水应答元件）结合，在植物感受干旱、高盐及低温等逆境条件时，激活一系列下游逆境应答基因的表达。

Dehydration_responsive element_binding ( DREB ) proteins specifically binding with dehydration_responsive element ( DRE ) have been identified as a kind of important transcription activator of plants under drought , high salt and cold stress .

环磷酸腺苷应答元件调节器与精子发生

When you want have a loop cAMP-responsive element modulator and spermatogenesis

孤生受体的相互作用对视黄酸应答元件的影响

Interaction of Orphan Receptors and Their Effect on Retinoic Acid Receptor Elements

牛泡沫病毒反式激活因子在内部启动子上应答元件的研究

Regulatory Elements That Mediate Transactivation by Tas in the Internal Promoter of Bovine Foamy Virus

前列腺专一蛋白因子抑制雄激素受体与其应答元件作用

A Prostate specific Protein Factor Inhibits the Interaction of Androgen Receptors with Hormone Response Elements

雷洛昔芬对血管内皮细胞雌激素应答元件转录活性的影响

Effect of selective estrogen receptor modulator raloxifene on estrogen responsive element transcriptional activity in vascular endothelial cells

启动子顺式元件扫描发现该基因含有大量的非生物胁迫、光以及植物激素应答元件。

A promoter scan detected numerous cis-elements implicated in abiotic stress , light , and phytohormone responses .

肾小球系膜细胞转化生长因子-β1基因启动子中氧化低密度脂蛋白应答元件的研究

The cic-element response to oxidized low density lipoprotein of TGF - β _1 promoter in mesangial cell

在体内通过与雌激素的结合，激活含雌激素应答元件基因和含有其他转录因子结合元件基因的表达，进而导致乳腺癌的发生。

In vivo , ER combine with estrogen and active the genes which contain estrogen response element and transcription factor response element , then lead to breast cancer .

核受体家族的经典作用机制是在其配基存在下结合在靶基因的应答元件上，从而在转录水平上调节基因的表达。

The classical mechanism for nuclear receptors to regulate gene expression is to bind the hormone response element ( HRE ) on the target gene in the presence of their ligands .

功能已知的差异表达基因中有大量基础代谢相关基因、次生代谢相关基因、细胞壁代谢相关基因、转录因子、胁迫响应蛋白、激素应答元件、细胞信号传导、细胞防御相关基因等。

Some of them had homologues involved in primary metabolisms , secondary metabolisms , cell wall metabolism and so on . And others of them had homologues which coded transcription factors , stress-responsible proteins , hormone responsible elements , signal transduction proteins , cell defensive associated proteins et al .

方法：合成源于各种缺氧应答基因的缺氧应答元件（HRE）寡核苷酸序列，与CMV启动子连接组合，测定荧光素酶的相对活性以确定缺氧转录活性。

Methods : Hypoxia response element ( HRE ) oligonucleotides derived from hypoxia response genes were synthesized and linked with CMV promoter to construct hypoxia response promoters .