应激性溃疡

质子泵抑制剂和H2受体阻滞剂类药物预防脑卒中后应激性溃疡出血的系统评价

Proton Pump Inhibitor and H_2RA Pharmacological Prevention of Stress Ulcer Bleeding in Stroke Patients : A Systematic Review of Randomized Controlled Trials

急性脑血管病并发应激性溃疡出血临床观察

Clinical Observation of Acute Cerebral Vascular Disease Complicated With Stress Ulcer Hemorrhage

结论：C组是治疗应激性溃疡的最佳方案。

CONCLUSION : The best pharmaco-therapeutic scheme was C.

应激性溃疡大鼠血及胃粘膜SOD、LPO浓度的变化

Changes of SOD and LPO in the Blood and Gastric Mucous Membrane of Rats Suffered from Stress Ulcer

方法：62例应激性溃疡合并上消化道出血患者随机分为两组：洛赛克组（40mg，iv，bid，疗程3～10天）共33例；

62 patients with upper gastrointestinal bleeding from stress ulcer were randomly divided into two groups .

应激性溃疡大鼠血浆EGF水平和胃上皮细胞凋亡的变化

Changes of Plasma EGF and Apoptosis of Gastric Epithelium Mucosae in Experimental Stress-induced Ulcers in Rats

目的探讨一氧化氮（NO）在大鼠应激性溃疡（SU）中的作用及L-精氨酸的预防机制。

Objective To observe the effects of nitric oxide ( NO ) on stress ulcer ( SU ) in rats .

p38丝裂原活化蛋白激酶在应激性溃疡发病中的作用

Role of p38 mitogen - activated protein kinase in the pathogenesis of stress ulcer

观察两组患者应激性溃疡、中毒性肠麻痹和MODS的发生率。

The incidence of stress ulcer , toxic ileus and MODS was observed in the two groups .

目的：探讨血管紧张素Ⅱ拮抗剂在大鼠应激性溃疡（SU）中的作用.方法：水浸束缚应激后，肉眼计算胃黏膜溃疡指数（UI）；

AIM : To investigate the role of angiotensins ⅱ antagonist in the occurrence and development of stress ulcer in rats .

结果78例患者中21例发生了应激性溃疡出血，其入院时的pHi均值与未出血组无显著差异；

Results 21 cases in bleeding group developed stress ulcer bleeding .

目的探讨褪黑素（MT）对大鼠胃应激性溃疡的影响及机制。

Objective To explore the protective effects and mechanism of melatonin ( MT ) on gastric stress ulcers in rats .

目的：探讨合理的肠内营养（EN）对重度脑损伤合并上消化道应激性溃疡出血的防治作用。

Objective : To investigate the treatment effect of rational enteral nutrition in stress ulcer bleeding after severe brain injuries .

应激性溃疡出血（SUB）发生率对照组明显高于观察组，P0.01。

The SUB ( stress ulcer bleeding ) morbidity of control group was high than that of treatment group ( P 0.01 ) .

目的系统评价质子泵抑制剂（PPI）与H2受体阻滞剂（H2RA）预防脑卒中后应激性溃疡出血的临床疗效及安全性。

Objective To assess the clinical efficacy and safety of proton pump inhibitor ( PPI ) and H_2RA for stress ulcer bleeding in stroke patients .

结论H2受体阻滞剂&雷尼替丁在预防重度颅脑损伤合并应激性溃疡、上消化道出血有显著疗效，而且此方法应用简便，成本低廉，容易推广。

Conclusions H2 receptor antagonist Ranitidine reduces stress ulcer and upper gastrointestinal hemorrhage in severe brain injury in children .

COx一1在应激性溃疡自愈各组和对照组中均表达，自愈各组与对照组相比没有明显差异。

COX-1 expressed in gastric mucosa of control group and each group during the healing course after termination of WRS .

结果：颅脑损伤后并发应激性溃疡时EGF、SOD浓度显著低于非应激性溃疡组。

Conclusions : The results indicate a close relationship between serum levels of EGF , SOD and head injury combined with secondary stress ulcer .

结论：MT可有效预防应激性溃疡的发生，其机制可能与MT抑制氧化应激诱导的NFκB过度活化有关。

CONCLUSION : Melatonin can prevent the development of stress ulcer via a mechanism involving in reducing oxidative stress induced NF κ B activation in gastric mucosa .

应激性溃疡患者血浆与胃液中MTL水平相比无明显差异（P＞0.05）。

In stress ulcer patients , there was no significant difference between the plasma MTL level and gastric juice MTL level ( P > 0.05 ) .

1%碳酸氢钠预防新生儿HIE应激性溃疡的临床观察

Clinical Effect of 1 % Sodium Bicarbonate ( 1 % SB ) on Preventing Acute Stress Ulcer in Neonates with HIE

结论：中央杏仁核内NT对胃应激性溃疡的细胞保护作用主要是通过调节多巴胺能神经传递实现的。

CONCLUSION : At the level of CA the gastric cytoprotective effect of NT under stressful conditions may be related to mechanism modulating dopaminergic transmission .

研究了抗氧化剂谷胱甘肽（GSH）、抗坏血酸、维生素E、叶酸对大鼠浸水应激性溃疡的影响。

The effects of glutathione ( GSH ), antiscorbutic acid , vitamin E and folic acid on gastric stress ulcer induced by water immersion in rats have been studied .

结果：在应激性溃疡中，HSPs及EGF未体现保护胃组织作用。

Results : In the stress ulcer , HSPs and EGF did not reflect the protection role of gastric tissue .

结论急性脑损伤患者应激性溃疡发生与血浆及胃液中MTL水平增高有关。

Conclusion Stress ulcer after acute cerebral injury correlates with increased MTL in the plasma and gastric juice .

方法双侧中央杏仁核内注射微量NT和抗NT血清，观察中央杏仁核外源性、内源性NT对胃应激性溃疡的影响。

Method NT and antineurotensin were injected into CEA of the rat respectively in order to study the effect of endogenous and exogenous NT on gastric stress ulcer .

所有患者每12h均予雷尼替丁100mg静脉注射预防应激性溃疡。

All the patients were given 100 mg ranitidine every 12 hours through injection of vein to prevent the stress ulcer .

应激性溃疡（stressulcer，SU）是各种临床危重疾病和严重心理障碍的常见并发症，具有较高的发病率和死亡率，其发生机制目前尚未完全清楚。

Stress ulcer ( SU ) is a usual complication of clinical serious diseases and serious psychosis in clinic . It has a higher incidence and mortality , while its genesis mechanism is not very clear yet .

[目的]探讨24h持续注入营养液的鼻饲方法对危重病人应激性溃疡发生率的影响。

Objective : To probe into the influence of infusing nutritional fluids continuously for 24 h via nasal feeding tube on incidence of stress ulceration in critical patients .

目的探讨H2受体阻滞剂（雷尼替丁）预防小儿颅脑损伤合并应激性溃疡、上消化道出血的确切疗效。

Objective To evaluate the efficacy of H2 receptor antagonist , Ranitidine , in prevention of stress ulcer and upper gastrointestinal hemorrhage in children with severe brain injury .