左旋多巴

HPLC法测定藜豆中左旋多巴的含量

Determination of Levodopa in Mucuna macrocarpa Wall by HPLC The Bean Eaters

结果PD大鼠旋转行为、黑质细胞凋亡数及bcl-2mRNA随着左旋多巴治疗的时间、剂量增加而增加。

Results The rotational behaviour , substantia nigral apoptosis , bcl-2 mRNA were increased with the doses and durations of levodopa .

pH指示剂吸收度比值法测定左旋多巴

Determination of LAEVODOPA by the method of pH indicator absorbance ratio

采用HPLC法建立测定藜豆中左旋多巴含量的方法。

To establish a method for determination of Levodopa in Mucuna macrocarpa Wall by HPLC .

目前PD的治疗主要是左旋多巴的替代治疗，并不能阻止病情的进展。

The main treatment of PD is the replacement therapy using levodopa , it can not slow down the progress of PD .

结论长期使用左旋多巴对6OHDA单侧损毁的PD大鼠残存的黑质DA能神经元无毒性作用。

Conclusion It suggests that a three-month oral levodopa treatment should be not toxic for the remaining dopaminergic neurons in rats with a unilateral 6-OHDA lesion .

经左旋多巴治疗后，10只PD大鼠中有8只出现了异常不自主运动，包括刻板动作和对侧旋转行为，并且每只大鼠的异常不自主运动均不同；

After the treatment with levodopa methylester , 8 of 10 rats displayed abnormal involuntary movements , including stereotype and contralateral rotation , the types of movements varied .

左旋多巴在治疗Lewy小体痴呆中的作用

The role of levodopa in the management of dementia with Lewy bodies

【结论】低剂量的左旋多巴干预后帕金森病大鼠纹状体Ml受体蛋白表达和乙酰胆碱含量是一个动态重塑的过程。

【 Conclusion 】 PD rats with low doses of levodopa after the intervention of the M1 receptor protein expression in the striatum and acetylcholine content is a dynamic process of change .

结论由慢性左旋多巴治疗PD大鼠诱导其产生的AIM与人类左旋多巴诱导的异动症（LID）具有相似的特点，为人类LID的研究提供了有效、经济、实用的动物模型；

Conclusion Levodopa-induced rat AIM model of PD demonstrated similar properties with the levodopa-induced dyskinesia ( LID ) in PD patients , and provided an effective tool for LID study .

建立了毛细管电泳紫外检测测定美多芭片剂中左旋多巴和羟苄丝肼的方法，优化了缓冲溶液浓度和pH、分离电压和进样时间等条件。

A method of determination of levodopa and benserazide in Madopar tablet by capillary electrophoresis with ultraviolet detection was established . The pH and concentration of the running buffer solution , separation voltage and injection time were optimized .

目的研究纹状体区神经生长因子诱导蛋白-β（NGFI-β）的表达变化在左旋多巴诱发的异动症（LID）形成中所起的作用。

Objective To study the expression of nerve growth factor inducible protein B gene ( NGFI β) in striatum in the pathogenesis of levodopa-induced dyskinesias ( LID ) .

目的：观察复方左旋多巴和吡贝地尔单用和联合应用对早期帕金森病（PD）患者非运动症状的影响。

Aim : To observe the influence of mono-use or combined use of piribedil on mental status , depression , sleep , activity of daily living and living quality in early stage PD patients .

结果：该药可明显减少左旋多巴所致狗和硫酸铜所致家鸽呕吐次数（P0.01，P0.05），延长呕吐潜伏期（P0.01）；

Results : The capsule can obviously decrease the vomiting times ( P 0.01 , P 0.05 ) and delay the vomiting delitescence of the dog and the pigeon ( P 0.01 ) .

目的：观察左旋多巴和吡啶斯的明对脑垂体生长激素（hGH）分泌的影响。

Objective : To observe the effect of levodopa and pyridostigmine bromide on secrection of pituitary growth hormone ( hGH ) .

但是，以左旋多巴（levodopa，L-dopa）为主的抗PD药物只能控制症状，不能阻止疾病进程，同时长期使用也存在较多的不良反应和副作用。

However , anti-PD with levodopa-based drugs can only control the symptoms , not prevent disease progression , and there are many adverse reactions and side effects after long-term use .

皮层电刺激对左旋多巴诱发异动症大鼠纹状体c-fos及ENK表达的影响

The effect of the cortical electrical stimulation on the expression of the c-fos and ENK in striatal neurons of rats with levodopa-induced dyskinesia

与左旋多巴的神经毒性不同，越来越多的证据表明DA受体激动剂可能具有神经保护作用，其机制可能是直接清除自由基或增加自由基清除酶的活性，以及增加神经营养作用。

Unless levodopa 's neurotoxin , more and more evidences support that DA receptor agonist may have neuroprotective effects via direct scavenging of free radicals or increase the activities of radical-scavenging enzymes , and enhancing neurotrophic activity .

目的比较左旋多巴-苄丝肼、培高利特、司来吉兰治疗帕金森病的疗效，观察其对纹状体突触后多巴胺D2受体的作用，筛选出适合治疗早期帕金森病的药物。

Objective To select the suitable antiparkinsonian drugs among levodopa-benserazide , pergolide and selegiline for patients with early-stage idiopathic Parkinson 's disease by observing the effects on dopamine D_2 receptor .

新的研究结果表明神经病变在帕金森病患者更加普遍的，并指出维生素B12缺乏与左旋多巴的累积暴露存在一个潜在的联系。

New findings show that neuropathy is more prevalent in'patients with Parkinson 's disease , and point to a potential link with vitamin B12 deficiency and cumulative levodopa exposure .

结论：左旋多巴和吡啶斯的明对脑垂体生长激素的分泌有良好的刺激作用，可以作为hGH激发试验的刺激药物。

Conclusions : Levodopa and pyridostigmine bromide have obvious stimulative effect on pituitary secretion of hGH , and may be used as stimulants in hGH stimulation test .

目的探讨左旋多巴诱发异动症（LID）大鼠模型的行为学特点，以及探寻有效评估异动症大鼠行为学特点的客观方法。

Objective To study the behavioral characteristics of a rat model of the levodopa-induced dyskinesia ( LID ) and the related factors , and to define clinically the relevant methods for assessing akinesia and dyskinesia in LID rats .

左旋多巴诱发异动症大鼠纹状体前强啡肽原基因与DARPP-32蛋白磷酸化的关系

Relationship between prodynorphin ( PDyn ) gene expression and phosphoprotein ( DARPP-32 ) phosphorylation in rats with levodopa-induced dyskinesias

PPD患者普遍对安坦和金刚烷胺敏感，较少出现左旋多巴制剂所致的运动障碍、开关现象和剂末恶化。

The patients with PPD are usually sensitive to artane and to amantadine hydrochloride . Levodopa or levodopa preparations-induced movement disorders , on-off phenomenon and end of dose deterioration occur less in the patients with PPD .

结果：左旋多巴和吡啶斯的明刺激后正常儿童hGH峰值为32.4±22.6和27.7±13.6ng/ml，假阳性率为10%和15%，两组无显著差异（P0.05）；

Results : After stimulated with levodopa and pyridostigmine bromide the hGH peak value of normal children were 32.4 ± 22.6 and 27.7 ± 13.6 ng / ml respectively . There was no statistical difference between the two peak values ( P 0.05 ) .

Permax是伊莱利利公司于1988年获得批准的、作为辅助治疗药物与左旋多巴用于帕金森氏症的治疗。

Permax was approved in1988 for Eli Lilly and Company as an adjunctive therapy with levodopa in Parkinson 's disease .

对模型成功的PD大鼠进行两套实验：第1套实验中3组PD大鼠接受每日2次左旋多巴（50mg穔g-1加苄丝肼12.5mg穔g-1）腹腔注射，持续22d。

Two sets of experiments were performed . In the first set , rats were treated with levodopa ( 50 mg · kg-1 with benserazide 12.5 mg · kg-1 , twice daily ), intraperitoneally ( ip ) for 22 days .

雷沙吉兰作为左旋多巴的辅助用药治疗帕金森病和运动波动患者（LARGO研究，雷沙吉兰每日1次辅助治疗的持久影响）：一项随机、双盲、平行分组试验

Rasagiline as an adjunct to levodopa in patients with Parkinson 's disease and motor fluctuations ( LARGO , Lasting effect in Adjunct therapy with Rasagiline Given Once daily , study ): A randomised , double-blind , parallel-group trial

本文以卡比多巴+左旋多巴（CD+LD）和灭吐灵（MCP）试验，观察了11例垂体泌乳素（PRL）瘤和7例健康女性血TSH和LH水平的变化，同时与血PRL的变化作比较。

This study was carried out by using dopaminergic agonist ( Garbidopa plus levodopa , CD + LD ) and antagonist ( metoclopramide , MCP ) tests to evaluate the variations of serum PRL , TSH and LH levels in 7 normal women and 11 women with PRL-secreting pituitary adenomas .

目的研究左旋多巴诱发异动症（levodopa-induceddyskinesias，LID）大鼠纹状体内前强啡肽原（prodynorphin，PDyn）基因表达与DARPP-32蛋白磷酸化状态的变化，探讨LID时直接通路过度活化的机制。

Objective To study the changes of prodynorphin ( PDyn ) gene expression and dopamine and cAMP-regulated phosphoprotein ( DARPP-32 ) phosphorylation and to explore the mechanism of over - activation in direct-pathway in rats with levodopa-induced dyskinesias ( LID ) .