奈韦拉平

目的：建立RP-HPLC法测定人血清中奈韦拉平的浓度。

Objective : To establish a RP-HPLC method to assay serum nevirapine .

本文介绍了抗HIV新药奈韦拉平的合成路线研究进展，并评价了其优缺点。

Synthesis methods for new drug Nevirapine of HIV were reviewed and their advantages and disadvantages were described in this paper .

司他夫定、拉米夫定、奈韦拉平联合治疗AIDS效果在临床应用中，拉米夫啶和干扰素（拉米夫啶联用或不与拉米夫啶联用）显示了令人振奋的效果。

Effect of combined use of stavudine , lamivudine and nevirapine on AIDS patients Lamivudine and interferon combination with or without lamivudine priming showed encouraging results in clinical trial .

目的：对HPLC法测定奈韦拉平含量的测量不确定度进行分析，以期找出影响不确定度的因素，为评价检测报告提供科学依据。

Objective : To find out the factors influencing uncertainty in determining content of nevirapine by HPLC method in order to provide scientific evidence for the measurement report .

目的了解确山县抗艾滋病病毒（HIV）治疗过程中，接受治疗（治疗方案为齐多夫定胶囊、去羟基甘散和奈韦拉平片）的患者的免疫学和病毒学指标的变化和耐药毒株的出现情况。

Objective To find out the alterations of the immunological and virological indexes and the emergence of resistant strains in the patients undergoing anti-HIV therapy ( receiving Zidovudine , Didanosine and Nevirapine ) .

方法采用随机双交叉实验设计，20名健康受试者口服受试制剂和参比制剂200mg，用HPLC法测定血浆中的奈韦拉平浓度。

Methods Twenty healthy male volunteers received 200 mg nevirapine tablets orally in a random crossover design . Drug concentrations in the plasma were determined by HPLC .

奈韦拉平由医药公司BoehringerIngelheim研制。

The drug company Boehringer Ingelheim developed nevirapine .

这些接受了两年抗转录病毒治疗的患者中，有48.2%的患者对常见的鸡尾酒疗法组合齐多夫定（AZT）、去羟基昔（DDI）和奈韦拉平（NVP）的组方治疗显示出了耐药性。

Of patients receiving two-year antiretroviral treatment , 48.2 per cent showed signs of drug resistance against a common combination of drugs Zidovudine , Didanosine and Nevirapine .

方法：用HPLC法测定原料药奈韦拉平的含量，并根据《（JJF1059-1999）测量不确定度评定与表示》中有关规定评估其不确定度。

Methods : The content of nevirapine in crude drug was determined by HPLC method and the uncertainty was appraised according to ( JJF1059-1999 ) Evaluation and expression of uncertainty of determination .

去羟肌苷、司他夫定联合奈韦拉平治疗艾滋病患者临床观察

Didanosine , Stavudine and Nevirapine in 20 cases of AIDS patients

国产奈韦拉平片健康人体相对生物利用度研究

Pharmacokinetics and Relative Bioavailability Study of Nevirapine in Healthy Volunteers

结论经统计学分析，国产奈韦拉平片剂与进口奈韦拉平片剂具有生物等效性。

Conclusion The test tablet and reference tablet were bioequivalent .

在此外，奈韦拉平已被证明是有问题的。

In addition , nevirapine has proven to be problematic .

但是它的费用是奈韦拉平的2倍。

But it costs twice the price of nevirapine .

奈韦拉平是包含在这里面的小袋放置了一个小滴管。

The nevirapine is contained in a small dropper placed inside the pouch .

非核苷类逆转录酶抑制剂奈韦拉平

Nevirapine , a non-nucleoside reverse transcriptase inhibitor

目的：研究国产奈韦拉平胶囊与进口奈韦拉平片的生物等效性。

OBJECTIVE : To study the bioequivalences of both domestic nevirapine capsules and imported nevirapine tablets .

司他夫定、拉米夫定联合奈韦拉平治疗艾滋病患者12例效果评估

Evaluation on the effects of combined therapy with Stavudine , Lamivudine and Nevirapine in HIV / AIDS

去羟肌苷散、司他夫定和奈韦拉平联合治疗艾滋病患者6个月疗效观察

The first 6-months evaluation on the efficacy of combined therapy with didanosine , stavudine and nevirapine in AIDS patients

对奈韦拉平进行了三批实验验证，实验结果表明，收率、质量稳定，为工业化生产提供了一定的基础数据。

The experimental results showed that the yield and the quality were stable . It will be the foundation for the industrialized production .

此外，一份事件发生时的分析显示用奈韦拉平开始结核治疗像是第二次体验早期病毒学的失败。

In addition , a time-to-event analysis demonstrated that patients starting nevirapine with tuberculosis treatment were twice as likely to experience earlier virological failure .

他们接受治疗的唯一的药物是单剂量奈韦拉平当他们分娩时，主要是为了她们的婴儿。

The only drug they received was the single dose of nevirapine when they went into labor , largely for the sake of their babies .

第一种方法，他对在皮氏培养皿中生成的胚胎使用一种名为奈韦拉平的普通抗艾滋药物时，这种药物能破坏这种生物酶。

First , he exposed embryos created in Petri dishes to a common AIDS drug called nevirapine , which works by gumming the enzyme up .

结论自愿咨询、检测、阻断、临床观察证明奈韦拉平用于母婴阻断，临床好、价廉、服用、安全、无毒副作用、不婴幼儿生长发育。

Conclusion The clinical observation prove that nevirapine is cheap , convenience , safe , reliable , no side effect in AIDS block between mother and infant .

历史悠久的抗结核药物利福平减缓了肝脏处理奈韦拉平的能力，让这种抗艾滋病药物效果更差，而且导致了病毒浓度的增加。

The long-standing anti-TB drug rifampicin slows down the liver 's ability to process nevirapine , making the anti-HIV drug less effective and causing an increase in virus levels .

奈韦拉平比依法韦伦更廉价，科学家发现它对已经患有结核病的患者的效果更低，服用奈韦拉平的患者血液中的艾滋病病毒载量比服用依法韦伦的患者更高。

Nevirapine the cheaper of the two drugs was found to be less effective in patients with existing TB , with higher HIV loads in their blood than those on efavirenz .

2氯3氨基4甲基吡啶是合成抗艾滋病药物奈韦拉平的关键医药中间体。

Synthesis method of 2-chloro-3-amino-4-methylpyridine , a key intermediate in the production of nevirapine that has been established to be clinically useful for the treatment of infection by HIV-1 were reviewed in this paper .