外周免疫器官

脾脏是人体最大的外周免疫器官，在机体免疫反应中发挥了重要作用。

As the biggest peripheral immune organ , spleen plays an important role in immune reaction of human body .

结论：过继转输的胚胎抗原耐受T细胞定居于外周免疫器官，从而介导受体孕鼠对相应父系抗原的免疫耐受。

Conclusion : The adoptively transferred embryo antigen-tolerant T cells are resident in peripheral immune organ , other than materno-fetal interface , in the recipient pregnant mice , which is involved in materno-fetal immuno-tolerance mechanisms .

当外界的病原微生物或其它异物侵入机体，DC获取抗原，迁移至外周免疫器官中，在此过程中，DC获得成熟，主要表现为抗原摄取能力降低，而抗原递呈功能增强。

During this process , DC have gained powerful capability of presenting antigen , with their ability of taking up antigens decreased .

结果表明，内污染147￣Pm后，可明显抑制中枢免疫器官骨髓细胞和胸腺细胞及外周免疫器官脾脏B淋巴细胞的DNA合成，细胞增殖受到抑制；

At 2nd day after 147 ￣ Pm irradiation , the proliferation of bone marrow cells , thymus cells as well as spleen B lymphocytes was inhibited .

胸腺和脾脏IL-2及脾脏IFN诱生活性显著下降，表明感染REV后雏鸡中枢和外周免疫器官细胞免疫和体液免疫降低及细胞因子IL-2及IFN免疫调节减弱。

These indicated that REV infection in SPF chickens could produce dramatic decrease in cellular and humoral immunity and immunoregulation in the immune organs .

进一步研究发现，GKO小鼠中CD4和CD25双阳性调节性T细胞，在外周免疫器官的发育并没有受到影响。因此，γ-干扰素可以负调控DC的迁移及T细胞免疫应答。

Moreover , IFN - γ was not required for the development of CD4 + CD25 + regulatory T cells .

EAE大鼠中枢神经系统与外周免疫器官细胞凋亡的研究

A Study of Cell Apoptosis in the Central Nervous System and the Peripheral Lymphoid Organs in EAE Rats

雏鸡饲喂益生素后4～10天，其中枢免疫器官胸腺和外周免疫器官脾脏T细胞IL-2诱生活性较未饲喂益生素的对照雏鸡明显升高（P＜0.05或P＜0.01）；

The T lymphocyte IL-2 inductive activity of thymus and spleen was significantly higher from 4 to 10 days post feed ( PF ) than in control unfed group chicks ( P0.05 , P < 0.01 ) .

目的探讨脾脏树突状细胞（DCs）在多器官功能障碍综合征（MODS）外周免疫器官损伤中的病理过程和作用机制。

Objective To explore the pathological features of the splenic dendritic cells ( DCs ) and their role in the pathogenesis of multiple organ dysfunction syndrome ( MODS ) .

目的比较实验性自身免疫性脑脊髓炎（ExperimentalAutoimmuneEncephalomyelitis，EAE）大鼠中枢神经系统（CNS）与外周免疫器官中细胞的凋亡情况。

Objective To study the apoptotic lymphoid cells in the central nervous system ( CNS ) and the peripheral lymphoid organs in experimental autoimmune encephalomyelitis ( EAE ) rats .

前言：目的：研究实验性变态反应性脑脊髓炎（EAE）大鼠外周免疫器官中细胞凋亡的情况。

Objective : To investigate the apoptotic cell in the peripheral lymphoid organs in experimental autoimmune encephalomyelitis ( EAE ) rats .

同时在EAE病程不同阶段检测外周免疫器官及CNS内细胞凋亡的变化情况，进而探讨免疫耐受的机制，为EAE、MS的防治提供依据。

Furthermore , the status of apoptotic cell are simultaneously detected in the peripheral lymphoid organs and the CNS , and the possible mechanism of immune tolerance is discussed , which provided evidences for the prevention and treat of EAE and MS.

结论：Yaa基因对BXSB小鼠骨髓中B细胞系细胞的分化发育无影响，提示Yaa基因仅在外周免疫器官的成熟B细胞中表达活性；

Conclusion : Yaa gene has no effects on the differentiation and development of the bone marrow B cell lineage cells in SLE BXSB mice , suggesting that its activity only appears in the peripheral mature B cells .

外周免疫器官的组织结构和淋巴细胞发育在35日龄均达到成熟水平，这也表明雏鸡外周免疫器官的免疫功能在35日龄时达到成熟。

Tissue structure and the development of lymphocytes in peripheral immune organs achieve mature at 35 days .

观察应激对小鼠中枢免疫器官胸腺、外周免疫器官脾脏组织形态以及免疫细胞凋亡的影响；

And to explore the apoptosis of central and periphery immune organ thymus and spleen following restrain stress ;

脾脏是最大的外周免疫器官，位于血液循环通路上，每分钟大约有全身血容量的5%流过，在机体的免疫反应过程中脾脏也起着至关重要的作用。

Spleen is the largest peripheral lymphoid organ on path of blood circulation , and plays an important role of immune reaction .

外周免疫器官中淋巴细胞由中枢免疫器官迁移而来，经抗原刺激而分化增殖，继而产生免疫学功能。

Lymphocytes in peripheral immune organs immigrate from center immune organ . These lymphocytes can proliferate and generate immunological function stimulated by antigens .

再次证实兔淋巴球囊是外周免疫器官，主要行使体液免疫及消化吸收功能。

It has been proved again that the lymphoid sacculus of the rabbit is the peripheral organ . Its main function is humoral immunity , digestion and obsorption .

乌鸡的中枢免疫器官包括胸腺和法氏囊，外周免疫器官包括脾脏，消化道，呼吸道及泌尿生殖道的淋巴样组织等。

The silkie central immune organs containing thymus and bursa , while peripheral lymphoid organs including spleen and the lymphoid tissue of enteron , respiratory tract and genitourinary tract .

在出壳初期，雏鸡如何保护自身不受病原体的侵扰，外周免疫器官如何发育、功能是否完善、能否提供及时有效的免疫保护呢？这些已成为目前亟待解决的重要研究课题。

How the chickens out of crust at early stage can be protected against pathogens , how the peripheral immune organs grow and whether its function is perfect to provide effective protection ?

中枢免疫器官为免疫细胞的发生分化和成熟提供场所，外周免疫器官为成熟免疫细胞的定居增殖和产生免疫应答提供场所。

Immune cell differentiation and maturity take place in the central lymphoid organ , the peripheral lymphoid organ is the place where the ripe immune cell settle down , proliferate and develop the immune response .

外周免疫器官作为产生免疫应答的重要场所，是反映动物机体健康状况的晴雨表，其组织结构与功能随着免疫应答而发生变化。

The peripheral immune organs are the important place that can generate immune response and their structure and function change alone with the immune response . So it is the barometer which reflects the health status of organism .

应用现代免疫学新技术对传染性法氏囊病（IBD）疫苗免疫种鸡后，其子代雏鸡外周血液和免疫器官组织的免疫学变化进行了动态研究。

This experiment was undertaken dynamic study of immunological changes in the peripheral blood , immune organs and tissues of chicks from hens vaccinated with infection bursal disease ( IBD ) vaccine using the new technique of modern immunology .