吴茱萸

结论经筛选，吴茱萸中生物碱水提取的工艺路线为：煎煮0.5h，煎煮3次，每次用16倍量水，在此条件下吴茱萸中生物碱提取完全。

Conclusion After the experiment , the best technics route of extracting rutaecarpine from Evodia rutaecarpa is decoction 0.5 h , and decoction three times with 16 times quality water every time . Under this condition , the rutaecarpine is extracted completely from Evodia rutaecarpa .

阳新县吴茱萸母树林营建技术

Construction Technique for Seed Orchard of Evodia rutaecarpa in Yangxin County

吴茱萸次碱对高血压大鼠胸主动脉血管肽酶C表达的影响研究

Effect of Rutaecarpine on the Expression of Angiotensin C in Thoracic Artery of Hypertensive Rats

该实验为下一步研究SOD基因调控对吴茱萸抗旱强弱的影响及抗旱优良品种选育打下基础。

This experiment lays a foundation for breeding of drought resistance and SOD gene regulation .

吴茱萸次碱在人肝微粒体中对细胞色素P450酶的抑制作用

Inhibitory effect of rutaecarpine on cytochrome P450s in human liver microsome

中药吴茱萸RP-HPLC指纹图谱的研究

Study on RP-HPLC Fingerprint of Fructus evodiae

吴茱萸碱诱导人子宫颈癌HeLa细胞凋亡的机制研究

Studies on evodiamine induced HeLa cell apoptosis

GC-MS分析不同贮藏条件对吴茱萸挥发油成分的影响

GC-MS Analysis of the Effect of Storage Time and Condition on the Volatile Components of Fructus Evodia

此外，吴茱萸碱能够介导线粒体途径的细胞凋亡，并通过调节MAPK家族成员功能来调节细胞死亡。

Additionally , evodiamine induced mitochondria-mediated apoptosis and regulated cell death by modulation of MAPK family members .

采用混合淋巴细胞反应检测非黏附细胞在吴茱萸碱处理后的小鼠骨髓来源DC刺激下的增殖情况。

The capacity of murine marrow derived dendritic cell to present to nonadherent splenocytes after treated with evodiamine was detected by mixed lymphocyte reaction ( MLR ) . 2 .

目的用核磁共振氢谱（1H-NMR）指纹图谱对吴茱萸和其伪品花椒、蚕砂进行鉴别。

Objective1H-NMR fingerprints was established to identify Evodiae , Pericarpium Zanthoxylum and Feculae Bombycis .

对吴茱萸碱和吴茱萸次碱在D101树脂上的吸附行为及洗脱条件进行研究后，结果表明pH对吸附、洗脱影响很小；

Selecting several macroporous resins to study the adsorption and desorption function of Evodiamine and Rutaecarpin .

结论：吴茱萸碱能诱导小鼠肝癌细胞H22的凋亡。

Conclusion : Evodiamine can induce the apoptosis of liver cancer cells H_ ( 22 ) .

通过三种温通心阳药物（吴茱萸、附子、干姜）的水提物HPLC图谱比较我们未发现有共同的色谱峰，初步证明它们没有共同的作用物质。

There are three " Wentongxinyang " drugs ( Evodia , aconite , ginger ) HPLC Patterns of water extracts we found no peaks in common , initially prove that they have no common substances .

用正交试验寻找了吴茱萸总生物碱的最佳提取条件。以总生物碱含量为指标，安排L9（34）。

The optimum extracting conditions for total alkaloids in fructus evodiae were investigated by orthogonal test L9 ( 34 ) .

目的研究吴茱萸碱体外诱导L929细胞死亡的机制。

Objective To study the mechanism of L929 cell death induced by Evodiamine in vitro .

吴茱萸碱抑制了iDC部分共刺激分子的表达，对mDC的MHCⅡ分子和共刺激分子无影响。

Evodiamine inhibit the expression of partial costimulatory molecules in iDC and has no obvious effect on MHC ⅱ and other costimulatory molecules in mDC . 4 .

吴茱萸碱对DC作用涉及多个基因的表达调控，这些基因控制并影响着DC功能、分化和成熟，为进一步寻找药物靶点，提供了线索。

The effects of evodiamine on dendritic cell involve in regulation and expression of several genes , these genes contribute to the functions 、 differentiation and maturation of the dendritic cell , and provid the potentiality to seek the target of medicine .

目的优选吴茱萸中挥发油等非极性物质的超临界CO2流体提取（SFE-CO2）方法及工艺参数。

Objective To optimize the extracting method and technological parameters of nonpolar substances such as volatile oils in Fructus evodiae with supercritical fluid extraction ( SFE-CO2 ) technique .

SPE-HPLC测定复方吴茱萸巴布膏中吴茱萸碱和吴茱萸次碱血药浓度及药动学研究

Determination of evodiamine and rutaecarpine of compound Wuzhuyu cataplasm in plasma by SPE-HPLC : Application to its pharmacokinetics

结果吴茱萸次碱（100、300μg·kg-1，iv）能显著缩小心肌梗死面积，降低血清CK水平，升高血浆CGRP浓度。

RESULTS Pretreatment with rutaecarpine ( 100 or 300 μ g · kg-1 , i. v. ) significantly reduced the infarct area and creatine kinase release as well as a significant increase in plasma concentrations of CGRP .

吴茱萸加8倍量80%乙醇提取2次，每次2h，醇提液经浓缩、干燥后粉碎成细粉；

Fructus Evodiae was extracted with 8 times the amount of 80 % ethanol under reflux for 2 times , 2 hours each , and the extract was then condensed , desiccated and smashed .

方法采用HPLC法测定吴茱萸水提物中吴茱萸次碱的含量，测定结果进行方差分析，求出最佳条件。

Method To adopt the way of HPLC to determine the content of rutaecarpine which was extracted by using of water from Evodia rutaecarpa . Analysing the results of determination by using analysis of variance , and finding the best condition of extracting rutaecarpine .

方法用BL-420E生物机能实验系统测定吴茱萸提取物对正常大鼠血压的影响，持续观察240min。

Methods Blood pressure of rats was determined by biological function experimental system , that was administrated by extrac .

结果测定的10批吴茱萸样品有15个共有峰，共有峰相对保留时间的RSD为0.24%～1.3%，相对峰面积的RSD为11.8%～59.3%。

RESULTS There were 15 common peaks in the fingerprint of 10 samples . The RSDs of the relative retention time of the common peaks was 0.24 % - 1.3 % . The RSD of the relative peak area was 11.8 % - 59.3 % .

吴茱萸（EvodiaRutaecarpa（Juss）Benth）是重要中药材，其药效和药理在医药学中发挥着重要的作用，市场对吴茱萸的需求也越来越大。

Fructus evodiae ( Evodia rutaecarpa ( Juss ) Benth . ) is an important Chinese medicinal plant . Its efficacy and pharmacological medicine play an important role in the market on the Evodia the demand is also growing .

结果：确定吴茱萸汤的药效物质基础主要为产生X4，X9，X10和X12号色谱峰中的化学成分（已确认X9为吴茱萸次碱）。

RESULTS : The material basis of the Wuzhuyu decoction was found to be produced chiefly by the chemical constituents contained in No. X 4 , X 9 ( rutaecarpine ), X 10 and X 12 chromatographic peaks .

吴茱萸次碱和辣椒素对过敏反应所致血管收缩的影响

Influence of rutaecarpine and Capsaicin on vascular contraction induced by anaphylaxis

吴茱萸的药理作用与其温里功效

Pharmacological effects of Fructus evodiae and its actions warming the internal

吴茱萸穴位敷贴治疗缓慢性心律失常疗效观察

The Clinical Observation of Acupoint Application by Rutaecarpa to Treat Bradyarrhythmia