吡格列酮

这些早期的结果显示吡格列酮应用与膀胱癌风险之间没有总体的联系。

These early results showed no overall association between Actos exposure and risk of bladder cancer .

吡格列酮还能显著减轻PAN诱导的足细胞凋亡和坏死，而恢复足细胞的分化功能。

Further , pioglitazone significantly decreased PAN-induced podocyte apoptosis and necrosis while restoring podocyte differentiation .

二甲双胍和吡格列酮的离子对HPLC测定

Simultaneous Determination of Pioglitazone and Metformin by Ion-pair HPLC

吡格列酮和非诺贝特对SD大鼠体脂分布及能量代谢的调节作用

Regulatory effects of pioglitazone and fenofibrate on body fat distribution and energy homeostasis in SD rats

盐酸吡格列酮片的HPLC含量测定方法目的建立盐酸吡格列酮片的溶出度试验方法。

Determination of Pioglitazone Hydrochloride Tablets by HPLC OBJECTIVE To establish the method of Pioglitazone Hydrochloride Tablets on dissolution rate .

吡格列酮对高脂喂养SD大鼠visfatin蛋白表达的影响

Effect of pioglitazone on visfatin expression in high-fat diets fed SD rats

2型糖尿病巨噬细胞LPL和PPARγ的mRNA表达及吡格列酮对其表达的影响

Expression of macrophage LPL mRNA and PPAR γ mRNA in type 2 diabetes and regulation by pioglitazone

脂联素及其受体在吡格列酮抑制ApoE基因敲除小鼠主动脉粥样硬化中的作用

Role of adiponectin and its receptors in anti-atherosclerotic effects of pioglitazone on ApoE knocked out mice

结果吡格列酮可以抑制高糖高胰岛素诱导的心肌成纤维细胞数量、DNA合成及S+G2+M期细胞的百分比增加，并呈一定的剂量依赖性。

Results Pioglitazone inhibited the cell number 、 DNA synthesis and the percentage of S + G_2 + M in the cell cycle of cultured cardiac fibroblasts induced with high glucose and high insulin .

HPLC-MS同时测定人血浆中吡格列酮及其活性代谢产物的浓度

Simultaneous determination of pioglitazone and its two active metabolites in human plasma by HPLC-MS

吡格列酮对糖尿病大鼠肺泡巨噬细胞IL-12、TNF-a和NF-κB的影响

Effects of Pioglitazone on Interleukin-12 、 Tumor Necrosis Factor-a and the Activation of NF - κ B on Alveolar Macrophages in Experimental Diabetic Rats

模型诱发当天，在吡格列酮给药后2h注射MSU。

On the day of model induction , MSU was injected 2h after pioglitazone administration .

吡格列酮对2型糖尿病肾病患者血清AGE-肽和MCP-1的影响

Effect of pioglitazone on serum advanced glycosylation end product peptide and monocyte chemoattractant protein-1 in type 2 diabetic patients

结论R2很可能是胰岛素增敏剂吡格列酮改善肝脏胰岛素敏感性的重要作用机制之一。

Conclusions The increased expression of R2 mRNA may play a important role in pioglitazone-induced insulin sensitivity amelioration .

吡格列酮对STZ诱导的糖尿病大鼠肾脏和骨骼肌免疫损伤的治疗作用

The Effects of Pioglitazone on the Autoimmune Injuries to the Kidneys and the Skeletal Muscle in STZ-induced Diabetic Rats

目的：评估胰岛素增敏剂吡格列酮对2型糖尿病（T2DM）患者血浆内皮素（ET）水平的影响。

Objective : To evaluate the effects of pioglitazone , a insulin sensitizing agent , on plasma endothelin levels in patients with type 2 diabetes .

地塞米松与吡格列酮对哮喘TH1/TH2细胞因子作用机制的比较

Comparison between effects of dexamethasone and PPAR γ agonist pioglitazone on intracellular cytokines expression of T_H1 / T_H2 and the mechanism of that in asthma model

盐酸吡格列酮的考马斯亮蓝G250光度测定法

Spectrophotometric method for determination of pioglitazone hydrochloride with Coomassie brilliant blue G250

目的观察二甲双胍、吡格列酮联合应用治疗新诊断肥胖2型糖尿病（T2DM）的疗效。

Objective To investigate the therapeutic effect of metformin combined pioglitazone on the newly diagnosed obesity type 2 diabetes ( T2DM ) .

结论：盐酸吡格列酮能预防高脂诱导IR的发生，其机制与降低血清胆固醇和甘油三酯含量及促使脂肪组织重新分布有关。

Conclusion : Pioglitazone could prevent the development of insulin resistance of in the rats induced by high-fat diet , and its mechanism was involved the decreasing of serum cholesterol and triglyceride , redistribution of fat tissue .

目的观察吡格列酮和二甲双胍联合治疗肥胖型多囊卵巢综合征（Polycysticovarysyndrome，PCOS）后，体重、胰岛素敏感性和排卵情况的变化。

Objective To study the therapeutic effects of pioglitazone and metformin for obese polycystic ovary syndrome ( PCOS ) cases by observe the change of body weight , sensibility to insulin , ovulation .

结果10μmol·L-1浓度的吡格列酮在对高糖高胰岛素诱导的肥大心肌细胞的蛋白含量、蛋白合成及体积均有显著的抑制作用。其抑制肥大的效果比维拉帕米更为明显；

Results Compared with verapamil , Pioglitazone significantly inhibited the protein content , cellular protein synthesis and volumes of cultured hypertrophic myocardial cells induced with high glucose and high insulin .

结论吡格列酮可明显减少早期糖尿病肾病患者的UAER，并有显著降低血糖的作用。

Conclusion Pioglitazone can obviously decrease UAER of patients with early DN , and have the function of lowering the blood sugar .

目的研究2型糖尿病（DM）抵抗素（resistin）、IL-6、颈动脉内膜中层厚度（IMT）、胰岛素抵抗的相关性，并应用吡格列酮干预治疗观察对上述指标的影响。

Objective To study the interrelationship among resistin , IL-6 , carotid intima-media thickness ( IMT ) and insulin resistance in type 2 diabetic patients , and therapeutic effects of pioglitazone .

蜕皮甾酮与吡格列酮对胰岛素抵抗模型细胞的葡萄糖参入率与葡萄糖消耗量差异无显著性（P0·05）。

The glucose uptake and glucose consumption of insulin resistance cells were not of the difference in the insulin resistance cells with ecdysterone and pioglitazone ( P0.05 ) .

结果盐酸吡格列酮组治疗后，2型糖尿病患者FPG和PPG2h（P<001）、HbA1c均较治疗前下降（P<0001）；

Results The FPG and PPG 2 h and HbA1c levels were significantly reduced after treatment with pioglitazone ( P < 0 01 ) .

吡格列酮对游离脂肪酸诱导的βTc3细胞凋亡的干预作用及其机制研究

The Study of Effects and Mechanism of Pioglitazone on β Tc3 Cell Apoptosis Induced by Free Fatty Acid

与安慰剂组比较，吡格列酮组经吡格列酮干预治疗3个月后resistin、IL-6水平、IMT、IRI均有显著下降。

Compared with placebo group , the levels of resistin , DL-6 , EMT and IRI were all significantly decreased on treatment group after treatment with pioglitazone for 3 months .

以体外培养的脑微血管内皮细胞来研究CRP在病理水平时对脑微血管可能的作用，尤其是对细胞粘附分子表达的影响，探讨可能的作用机制并考察辛伐他汀、吡格列酮等药物的作用。

To determine the possible effects of CRP on brain microvessel endothelium , we examined the effects of CRP on brain microvascular endothelial cells ( BMECs ) with emphasis on its relation to cell adhesions molecules .

目的：对服用盐酸吡格列酮胶囊的2型糖尿病（T2DM）患者进行观察及随访，对药物的长期疗效及安全性的做出总结与分析。

Objective : To explore and analyze the long-term curative effect and safety of Pioglitazone Hydrochloride Capsules in the treatment of Type 2 diabetes mellitus ( T2DM ) .