吡喹酮

吡喹酮对日本血吸虫感染鼠血管活性肠肽和物质P的影响

Effects of praziquantel on VIP and SP in rats infected with Schistosoma japonicum

经吡喹酮治疗后色素沉积量明显减少、虫卵肉芽肿减小（P均<0·01）。

After chemotherapy with praziquantel , the level of pigment decreased considerably ( P < 0 ^ 01 ) and the size of granuloma shrinked obviously too ( P < 0 ^ 01 ) .

维生素B6降低吡喹酮化疗血吸虫病主要副作用的研究

Study on vitamin b_6 to reduce the main side effects of praziquantel for schistosomiasis

吡喹酮、阿苯哒唑剂量递增法治疗脑囊虫病CT影像变化及临床意义

Changes of CT Images and Clinical Significance in Cerebral Cysticercosis Treated by PQT and ALB with Dose Increasing Method

用ELISA考核吡喹酮治疗家兔血吸虫病疗效的实验研究

A study on evaluating efficacy of praziquantel therapy in rabbits schistosomiasis by ELISA

临床症状不典型，常合并癫痫和皮下结节，主要依靠CT和病理检查确诊，成人剂量的吡喹酮安全有效。

Cerebral cysticercosis is main indi - cation . 2.Atypical clinical symptom , often associated epilepsy and subcutaneous nodule are final diagnosed depending on CT and pathology . Praziquantel is safe and effective given adult dose .

吡喹酮对NIH小鼠体内原头节及不同发育期细粒棘球蚴作用的组织学观察

Histological Observations on Protoscolices and Different Developmental Stages of Echinococcus granulosus Cysts in NIH Mice Treated with Praziquantel

吡喹酮长程疗法对NIH小鼠体内细粒棘球蚴的组织学影响

Histological Observations on the Effect of Long Term Therapy of Praziquantel on Echinococcus granulosus Cyst in NIH Mice

目前，治疗血吸虫感染主要使用吡喹酮（praziquantel），但是还没有有效的疫苗。

Schistosoma infections are currently treated with a drug called praziquantel , but there is no effective vaccine .

结果吡喹酮治疗组与感染组比较，TGFβ1，Ⅰ，Ⅲ型胶原含量明显降低（P<0.01）。

Results Compared with infected group , praziquantel can significantly reduce the content of TGF β 1 , type ⅰ and type ⅲ collagen in schistosomiasis mice with liver fibrosis .

吡喹酮及高剂量已酮可可碱可明显下调Fas／FasL的表达，抑制肝细胞凋亡，改善肝功能。

Praziquantel and high dose pentoxifylline can obvious to descend to adjust the expression of Fas / FasL , repress hepatocyte apoptosis and improve hepatic function .

结果提示，MSCs移植，尤其是和吡喹酮联合应用可以作为改善血吸虫性肝纤维化的有效措施。

The results suggest us that MSCs transplantation especially combined with PZQ can be as an effective measure to ameliorate the liver fibrosis induced by Schistosoma japonicum .

目的研究吡喹酮对血吸虫病肝纤维化小鼠肝脏TGFβ1和Ⅰ、Ⅲ型胶原表达的影响及其抗纤维化机制。

Objective To study the effects of praziquantel on the expression of hepatic TGF β 1 , type ⅰ and type ⅲ collagen in schistosomiasis mice with liver fibrosis and its anti fibrosis mechanism .

结论：吡喹酮治疗可使肝组织内SEA水平下降，从而抑制了虫卵肉芽肿的病变，但不能逆转已形成的虫卵肉芽肿病变。

CONCLUSION : Praziquantel treatment could lower the SEA level in the liver tissue , and thereby inhibit the egg granuloma formation , but it could not alter the antibody level , likewise , could not re - verse the egg granulomatous changes already formed .

国产Lorcainide对实验性心律失常的作用吡喹酮引起心律失常的中枢机制

Effects of home made lorcainide on experimental arrhythmia central mechanism of pyquiton induced arrhythmia

目前，血吸虫病的治疗主要依靠吡喹酮（PZQ）药物。

Current schistosomiasis treatment relies largely on a drug called praziquantel ( PZQ ) .

感染日本血吸虫小鼠1次口服75mg/kg左旋吡喹酮或150mg/kg的混旋吡喹酮后，间隔10min～7d不同时间取虫，以IFA分别检测整体虫和成虫切片的体表抗原。

Mice infected with Schistosoma japonicum were treated with a single oral dose of levo-praziquantel 75mg / kg or racemic praziquantel 150mg / kg .

动物一次口服吡喹酮120mg/kg后24h，皮层细胞质突起肿大，基质中分泌体减少，线粒体固缩；

24 hours after oral administration of single dose of 120mg / kg pyquiton to dogs infected with Pagumogonimus skrjabini , the tegumental cytoplasmic projections swelled , the mitochondria in the ground substance ;

本文用0.04mg/kg剂量的吡喹酮（Pyquton）对昆明小鼠体内寄生虫进行了药物净化，从血液学、生化学和病理学等方面，对用药动物进行了观察。

Using dosage 0.04 mg / kg Pyquiton to clean endoparasite in Kunming mice .

应用COPT、IHA、ELISA检测新流行区44例血吸虫病人吡喹酮治疗前后抗体水平变化。

The COPT 、 IHA and ELISA were used to detect the changes of antibody level in 44 patients with chronic schistosomiasis japonica before and after treatment with praziquantel in a new endemic area .

结论皮涂吡喹酮霜剂效果好于口服预防，透皮剂中Azone较理想，口服预防联合用药可降低剂量和毒性，提高防护效果。

Conclusion The preventing effect of praziquantel cream was better than that of oral prevention , azone was satisfactory as a dermal penetration accelerator , the combinative oral administration could decrease dosage and toxicity , and enhance the protective effect .

目的观察不同亚治疗剂量吡喹酮对慢性血吸虫病患者血清血吸虫肠相关趋阴极抗原（GACA）水平的影响。

Objective To observe the effect of different subclinical doses of praziquantel on the serum gut-associated cathodic antigen ( GACA ) levels in the patients with chronic schistosomiasis .

结果：吡喹酮的剂量为300mg·kg~（-1）时，宿主体内的21-d童虫示有轻度或中度的皮层褶嵴肿胀、融合、糜烂或破溃，且以盘状感觉器的肿胀为特征。

RESULTS : When the dose used was 300 mg . kg-1 , the worms showed mild or moderate swelling , fusion or even erosion and collapsed of the tegumental ridges , which was characterized by swelling of the discoid sensory structures .

方法Kato-Katz法粪检确定108例慢性血吸虫病患者，随机分成4组，分别给予口服5mg/kg、10mg/kg、20mg/kg剂量吡喹酮和安慰剂。

Methods 108 cases of patients with chronic schistosomiasis determined by Kato - Katz method were divided into 4 groups and given 5mg / kg 、 10mg / kg 、 20mg / kg body weight praziquantel and placebo respectively .

静脉注射吡喹酮清除率的降低可归于西米替丁降低肝血流的结果，而口服PQT清除率的降低主要可能与西米替丁对肝药酶的抑制有关。

The reduction in clearance of intravenous PQT could be attributed to the result of cimetidine lowering liver blood flow , whereas the reduction in clearance of oral PQT might be related mainly to the inhibition of cimetidine on the activity of hepatic drug-metabolizing enzymes .

吡喹酮在人体肝、肺包虫囊内的浓度测定

Determination of Praziquantel Concentration in Human Hepatic and Pulmonary Hydatid Cysts

吡喹酮对体外猪囊尾蚴作用的电镜观察

Electron microscopic observation on cysticercus cellulosae treated with pyquiton in vitro

中药保留灌肠联合吡喹酮治疗血吸虫性结肠病

Herbal retention enema combined with praziquantel in treatment of schistosomal colopathy

复方吡喹酮、吡喹酮及丙硫咪唑治疗猪囊虫病的对比试验

Comparison of Compound Praziquantel , Praziquantel and Albendazole for Cysticercosis Cellulosae

吡喹酮、尼立达唑和呋喃丙胺治疗埃及血吸虫病217例

Praziquantel , niridazole and furapromide in 217 cases of schistosoma haematobium