双嘧达莫

HPLC法测定复方制剂中双嘧达莫、阿司匹林及水杨酸限量检测

HPLC Determination of Dipyridamole , Aspirin and Salicylic Acid in Compound Preparation

然后着重详细的研究了双嘧达莫在不同pH缓冲液的溶解度和溶解速度。

Then we studied the solubility and intrinsic dissolution rate of dipyridamole in buffers with different values of pH.

复方双嘧达莫片的HPLC测定

Determination of compound dipyridamole tablets by HPLC

复方双嘧达莫缓释片中双嘧达莫与阿司匹林含量的RP-HPLC测定

RP-HPLC Determination for Extended Release Dipyridamole and Aspirin Compound

RP-HPLC法测定大鼠血浆中双嘧达莫浓度

Determination of dipyridamole in rats plasma by RP-HPLC

目的研究支链淀粉修饰双嘧达莫（DIP）脂质体的制备方法并考察其在小鼠体内的组织分布。

Aim To prepare amylopectin anchored dipyridamole ( DIP ) liposome and to study its tissue distribution in mice .

目的：建立复方缓释制剂中双嘧达莫、阿司匹林含量测定及水杨酸限量检测的HPLC方法。

Objective : To establish a HPLC method for determination of dipyridamole and aspirin , and develop a new method for limit of free salicylic acid .

目的：制备双嘧达莫pH非依赖型缓释微丸，使药物释放不受胃肠道pH值变化及个体差异的影响。

OBJECTIVE To prepare pH independent sustained release pellets of dipyridamole ( DIP ), the drug release not being influenced by pH of the gastrointestinal tract and by individual difference .

目的建立HPLC法测定银杏达莫氯化钠注射液中银杏总黄酮和双嘧达莫含量的方法。

Objective To establish a HPLC method for the determination of the contents of total flavonoids and dipyridamole in Ginkgo leaf extract and dipyridamole sodium chloride injection .

颈内动脉系统TIA患者~（99）Tc~m-ECD脑SPECT双嘧达莫负荷显像的研究

~ ( 99 ) Tc ~ m - ECD Brain SPECT with Dipyridamole Stress in Carotid Artery TIA Patients

结论双嘧达莫和多巴酚丁胺负荷MCE探测冠脉狭窄的能力相近。

Conclusions Dipyridamole and dobutamine have similar efficacy in identify coronary stenosis by MCE .

~（99m）Tc－MIBI心肌断层显像双嘧达莫试验诊断冠心病的临床价值

The value of dipyridamole ~ ( 99m ) tc-mibi myo-cardial tomoscintigraphy imaging for the diagnosis of coronary artery disease

结果：脑SPECT双嘧达莫负荷显像与静息显像相比较，共有10例患者在负荷状态下，局部放射性稀疏的程度较静息显像明显加重。

Results : Compared with baseline brain SPECT , there were altogether 10 patients who showed worsening of hypoperfusion in the dipyridamole SPECT .

动脉源性脑缺血后阿司匹林加双嘧达莫与单独阿司匹林治疗的比较（ESPRIT）：一项随机对照试验

Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin ( ESPRIT ): randomised controlled trial

结果平均回收率为双嘧达莫100.1%，RSD为1.01%；阿司匹林99.13%，RSD为1.26%。

Results The average recovery rate for dipyridamole and aspirin were 100.1 % with RSD 1.01 % and 99.13 % with RSD 1.26 % respectively .

结果西咪替丁与双嘧达莫均可延长感染病毒鼠的平均存活天数（P均小于0.05），西咪替丁还可降低小鼠的死亡率（P<0.05），但未观察到随西咪替丁浓度的增加有降低死亡率的特点。

Results Cimetidine and dipyridamole could both elongate the average life time of the mice affected tick borne encephalitis virus ( P < 0.05 ) . Cimetidine could decease the death rate of the mice affected tick borne encephalitis virus ( P < 0.05 ) .

双嘧达莫组与对照组相比，纤维蛋白原明显降低（P<0.01），红细胞变形指数明显升高（P<0.05），血浆SOD和MDA含量虽有改变，但差异均无统计学意义；

After intraperitoneal injection of dipyridamole injection , content of fibrinogen decreased ( P < 0.01 ) and index of red blood cell deformation increased ( P < 0.05 ) compared with those of control group .

观察EGB与银杏达莫（即EGB+双嘧达莫）对血小板功能影响的差异，探讨其机制。

Observe the different effect of EGB alone and EGB combined with dipyridamole on human platelet functions and investigate mechanisms of their synergistic action .

用HPLC-FLU法测定人血浆中双嘧达莫的浓度及其药动学

HPLC-FLU determination and pharmacokinetics study of dipyridamole in human Plasma

目的：探讨双嘧达莫（DP）预处理对大鼠原位肝移植缺血再灌注损伤（IRI）的保护作用及机制。

Objective : To evaluate the protective effect of dipyridamole ( DP ) preconditioning on ischemia / reperfusion injury in rat orthotopic liver transplantation and to explore the mechanism .

目的对比双嘧达莫和多巴酚丁胺负荷心肌超声造影（MCE）探测静息状态下无心肌血流限制性冠脉狭窄的能力。

Objective To compare the efficacy of dipyridamole and dobutamine with myocardial contrast echocardiography ( MCE ) in detecting the non resting flow limiting coronary stenosis .

目的应用冠状动脉血流显像技术结合双嘧达莫负荷试验探讨主动脉瓣狭窄患者主动脉瓣置换术（AVR）前后的冠脉血流储备（CFR）的变化。

Objective To investigate the coronary flow and coronary flow reserve ( CFR ) before and after aortic valve replacement ( AVR ) using coronary flow imaging combined with dipyridamole stress test .

目的和方法用Vero细胞及HEK293细胞体外培养法检测双嘧达莫对单纯疱疹病毒（HSV）的抑制活性，并以直线回归方程计算IC50值。

Objective and Methods To determine the inhibitory activity of dipyridamole ( DPM ) on replication of herpes simplex virus ( HSV ) ⅰ、ⅱ in Vero cells and HEK 293 cells in vitro .

结果表明，99mTc－MIBI双嘧达莫试验诊断冠心病的灵敏度为92.7%，特异性为85.7%，准确性为91.4%。

The results showed that the sensitivity and specifity of diagnosing CAD were 92.7 % and 85.7 % , respectively during dipyridamole test 99mTc-MIBI myocardial imaging . The accuracy was 91.4 % .

目的评价运动心电图试验（EET）、双嘧达莫心电图负荷试验（DPET）及联合应用（联合试验AT）对冠心病的诊断价值。

Objective To investigate the diagnostic value of exercise electrocardiography test ( EET ), dipyridamole electrocardiography test ( DPET ) and associated test ( AT ) in coronary artery disease ( CAD ) .

复方双嘧达莫缓释胶囊家犬体内的研究表明，T（max）普通片为3.19±0.21hr，而缓释胶囊为5.46±0.53hr，故明显延长。

The study on complex extended release capsules of dipyridamole in vivo of dogs showed that Tmax of extended release capsules ( 5.46 ± 0.53hr ) was longer than conventional tablets ( 3.19 ± 0.21hr ) .

方法选择10例冠状动脉造影正常（I组）和8例左前降支（LAD）存在50%～70%狭窄的患者（Ⅱ组），分别在静息状态和双嘧达莫负荷试验后进行两次IMCE检查。

Methods Intravenous myocardial contrast echocardiography ( IMCE ) was performed pre and post dipyridamole injection in 10 cases with normal coronary angiography ( group I ) and 8 cases with 50 % to 70 % stenosis in the lift anterior descending branch ( LAD ) ( group ⅱ) respectively .

方法13只开胸犬用冠状动脉缩窄器造成冠状动脉左旋支不同程度的狭窄，进行双嘧达莫负荷试验，首剂量为0.56mg/kg，4min后追加0.28mg/kg。

Methods Several grades of constriction on left circumflex coronary artery ( LCX ) were produced in 13 open-chest canine models . Dipyridamole was added in two steps , first 0.56 mg / kg , then 0.28 mg / kg after four minutes .

双嘧达莫抗单纯疱疹病毒的体外实验研究

Study on Anti Herpes Simplex Virus Activity of Dipyridamole in Vitro

双嘧达莫注射液治疗急性脑梗死的疗效观察

Therapeutic effect of dipyridamole injection on patients with acute cerebral infarction