单剂量

单剂量丝裂霉素C局部注射对翼状胬肉组织中血管和成纤维细胞的影响

The impact of single dose mitomycin C on vessel and fibroblasts in pterygium

结果与对照组比较，25mg/kg和50mg/kg的单剂量吉西他滨都对Lewis实体瘤生长有抑制作用（P<0.05）；

Results Single dose of 25mg / kg or 50mg / kg of gemcitabine had significant inhibiting effect on the growth of Lewis tumor .

药动学研究表明，家兔静脉注射单剂量的两性霉素B后其体内血药浓度时间数据符合权重为1/C的三室模型。

The concentration-time data of AmB after intravenous administration were fitted by three compartments with weight of1 / C.

单剂量钆贝葡胺在肝脏和中枢神经系统MRI检查中的联合应用

Application of gadobenate dimeglumine in the MRI of liver and central nervous system : single injection for double organs

目的探讨单剂量头孢曲松和头孢呋辛连用3d预防胃肠手术部位感染的效果并进行药物经济学分析。

Objective To compare the effects and pharmacoeconomics of single-dose of ceftriaxone versus 3-day cefuroxime prophylaxis in patients undergoing gastric or colorectal resection .

老年COPD患者单剂量口服氨茶碱的药物动力学研究

Study on the Pharmacokinetics of single Oral dose of Aminophylli (?) e in elderly COPD Patient

方法20名健康男性受试者随机交叉口服单剂量试验和参比甲钴胺片剂1500μg后，用微粒子捕捉酶免法测定血清中甲钴胺浓度，并评价2种制剂的生物等效性。

Methods A single oral dose 1500 μ g of tested and referenced mecobalamin tablets were given to 20 healthy volunteers in a randomized cross - over .

给10头猪分别按体重5mg／kg单剂量内服和肌注恩诺沙星。

Ten pigs were treated with enrofloxacin by oral or intramuscular administration , at a single dosage of 5 mg / kg .

方法：8名健康男性志愿者单剂量随机交叉po400mg布洛芬后，采用HPLC测定血浆药物浓度。

METHODS : The drug concentration in plasma was assayed by HPLC method after administration of a single oral dose of 400 mg ibuprofen to each of 8 healthy male volunteers .

方法SD大鼠分别单剂量给药500mg.kg-1，收集0~24h尿样。

Methods Urine samples from 0-24 h were collected after single ig dose of 500 mg · kg ~ ( - 1 ) daidzein to each of six rats .

目的：探讨COPD患者单剂量口服优喘平的血药浓度变化及临床意义。

OBJECTIVE : Exploring changes in blood drug concentration after single oral dose of theophylline ( Protheo ) in elder patients with COPD and their clinical significance .

单剂量po给药后，降血压有效血药浓度可维持8～10h。

Following a single oral dose of verapamil , the effective plasma concentration of hypotensive effect maintained 8 ~ 10 h.

方法20名志愿者单剂量口服150mg的罗红霉素肠溶胶囊，采用LC-MS法测定其血清中罗红霉素浓度。

Methods 20 male healthy subjects received a single dose of 150 mg roxithromycin enterosoluble capsules .

方法：采用HPLC法测定18名男性健康受试者单剂量交叉口服100mg2种盐酸曲马多片剂后不同时间血浆中的药物浓度。

Methods : Single oral doses of the standard formulation and the tested formulation were respectively given to 18 volunteers in randomized cross-over test . The tramadol concentrations in plasma were determined by HPLC .

方法：20名受试者单剂量口服Gli片10mg后，在规定时间取血，HPLC法测定血药浓度。

Methods : The glipizide concentrations in sera of 20 subjects were determined by HPLC following an oral single dose of 10 mg .

单剂量Res0.5mg·kg~（-1）加速Mor身体依赖的形成。

A single dose of Res ( 0 . 5 mg · kg-1 ) speeded up the development of physical dependence on Mor .

结论麻醉诱导期单剂量静脉滴注头孢三嗪2g能有效预防糖尿病病人择期胆囊切除术后切口感染的发生。

Conclusions Single_dose CTRX 2g injected intravenously during the induction of anaesthesia was able to prevent the infections after gall surgery for diabetics .

方法：12例男性健康志愿者单剂量口服80mg替米沙坦片，采用高效液相色谱法测定体内替米沙坦的血药浓度。

Methods : 12 male healthy volunteers orally received a single dose of telmisartan tablets 80 mg .

方法：21名健康男性受试者参加了单剂量（600μg）三周期交叉试验并用放免分析法测定给药后不同时间点血清药物浓度。

METHODS : 2 1 healthy male volunteers received a single oral doses of 600 μ g of levothyroxine sodium in three times cross - over clinical trial and their serum drug concentration were determined by Radioimmunoassay ( RIA ) .

6名健康志愿者随机交叉po单剂量10mg氨氯吡咪国产或进口片。

The pharmacokinetics of amiloride was determined following a single oral dose of 10 mg given to each 6 volunteers in an open randomized crossover study .

单剂量分别口服500mg进口羟苯磺酸钙胶囊（R），国产羟苯磺酸钙片剂（T1）和胶囊剂（T2）进行人体生物等效性研究。

Subjects received a single oral dose of 500 mg calcium dobesilate capsule and tablet produced by imported ( R ) and domestic ( T1 , T2 ) .

实验方法采用RP-HPLC法测定6条健康beagle犬单剂量口服阿昔洛韦缓释片与普通片后，阿昔洛韦的血药浓度变化。

METHODS Blood concentrations of Acyclovir were determined by RP-HPLC after a single oral dose of two kinds of Acyclovir tablet was given separately to 6 beagle dogs .

结果在单剂量BH4口服负荷试验中，典型PKU患者的血苯丙氨酸水平没有降低。

Results In a single BH4 loading test , no classic PKU patients demonstrated decreases in serum phenylalanine levels .

方法：液相色谱质谱联用法（HPLC-MS）测定12名健康男性受试者单剂量口服4mg甲磺酸多沙唑嗪片后的血药浓度，由DAS2.0药学与统计程序处理计算药动学参数。

METHODS After given doxazosin mesilate tablets 4 mg to 12 healthy male volunteers , doxazosin concentrations in plasma were determined by HPLC-MS.

应用此法研究了6只比格犬单剂量po盐酸氢吗啡酮缓释片4mg后的药代动力学特征。

The method was used to determine the pharmacokinetic parameters of HYD after a single oral administration of 4 mg HYD sustained release tablets to Beagle dogs .

方法单剂量给予国产的复方格列吡嗪片505mg（试验制剂）和格列吡嗪片5mg（参比制剂）、盐酸二甲双胍片500mg（参比制剂）。

Methods A single oral dose ( 5 mg of Glipizide and 500 mg of Metformin hydrochloride ) was given to volunteers .

方法采用双周期试验设计，选用12名健康志愿者单剂量及多剂量po200mg奥扎格雷钠口服液，建立HPLC测定奥扎格雷钠的血药浓度并计算药动学参数，进而对主要药动学参数进行统计分析。

Pharmacokinetic Study on Ozagrel in Twelve Healthy Volunteers METHODS In a two period study , 12 healthy male volunteers received a single dose and multiple-dose regimen of 200 mg ozagrel . The plasma concentrations of ozagrel were determined by HPLC .

方法：18名健康志愿者分别双交叉口服单剂量国产头孢拉定胶囊和进口头孢拉定胶囊各0.5g，用反相高效液相（RPHPLC）法测定血浆中头孢拉定浓度。

Methods : According to crossover design , each volunteer was given a single dose of 0.5 ? g domestic or imported cephradine capsule . The plasma concentrations were determined by RP-HPLC .

方法18名健康受试者单剂量口服氯雷他定20mg后，血浆样品经液液萃取，通过液相色谱质谱联用法测定其质量浓度，并计算药动学参数。

Methods After a single dose oral administration of loratadine 20 mg to 18 healthy Chinese male volunteers , the plasma concentrations of loratadine were determined .

方法：健康志愿者18名，随机单剂量口服国产盐酸舍曲林胶囊和进口盐酸舍曲林片，剂量均为100mg，剂间间隔为2周。

Methods : A single oral dose ( 100 mg of capsules and reference formulation ) were given to 18 healthy volunteers in a randomised crossover study .