免疫球蛋白重链

B细胞淋巴瘤免疫球蛋白重链基因重排的检测

The Detection of Rearrangement of Immunoglobulin Heavy Chain ( IgH ) Gene in B Cell Lymphoma

克隆性免疫球蛋白重链基因重排检测可以作为诊断恶性B细胞性非霍奇金淋巴瘤的有效分子标志。

Clonal immunoglobulin heavy chain gene rearrangement can be used as a effective diagnostic molecular marker for B-NHL .

石蜡包埋B细胞性恶性淋巴瘤组织克隆性免疫球蛋白重链基因重排检测研究

Study on Detection of Clonal Immunoglobulin Heavy Chain Gene Rearrangement in Paraffin-embedded Tissues from B-cell Lymphomas

免疫球蛋白重链框架区九肽诱导抗急性B淋巴细胞白血病的细胞毒T细胞应答

Induction of anti-B-cell acute lymphoblastic leukemia cytotoxic T lymphocyte response against immunoglobulin heavy chain frame-derived nonapeptide

从小鼠胎儿基因文库中筛选分离免疫球蛋白重链Cε基因

Screening and Isolating of Mouse Immunoglobulin Heavy Chain C ε Gene from New Born Mouse DNA Library

利用PCR筛选噬菌体文库人免疫球蛋白重链Cγ基因的一种新方法

A new method used to screen the human immunoglobulin heavy chain C γ gene by means of PCR-screening phage library

免疫球蛋白重链基因重排及bcl-2/JH融合基因检测眼眶淋巴细胞增生性疾病

The clinical value of rearrangement of IgH gene and bcl-2 / J_H fuse gene in the diagnosis of orbital lymphoproliferative disorders

目的：初步阐明急性B淋巴细胞白血病（B鄄ALL）免疫球蛋白重链（IgH）基因克隆性重排的发生及其异质性。

To document the occurrence and heterogeneity of clonal rearrangements of immunoglobulin heavy chain ( IgH ) gene in acute B lymphoblastic leukemia ( B-ALL ) .

GATA-2与免疫球蛋白重链胚系基因Cμ在白血病细胞中的表达及其意义

Expression of GATA-2 Gene and Immunoglobulin Heavy Chain Germline Gene C_ μ in Leukemia Cells and Its Significance

用免疫球蛋白重链J区（JH），K轻链及λ轻链C区（Ck、Cλ2）基因探针及Southern印迹杂交技术，对22例非何杰金氏淋巴瘤进行分析。

The B-cell clonality of 22 cases of non-Hodgkin 's lymphoma was analysed by using the immunoglobulin JH , CK and C_ λ gene probes and Southern blot hybridization method .

对分离的两株阳性克隆进行序列分析研究，发现这两个克隆DNA序列相同，均为人免疫球蛋白重链可变区序列，属人IgG基因Ⅲ家族，长度为384bp，与期望的660bp相差276bp。

Two sequenced clones had identical DNA sequence with 384 bp , which was 276 bp less than the expected 660 bp . The antibody gene belongs to human IgG ⅲ gene family .

目的：评价B细胞淋巴瘤（B-NHL）患者外周血免疫球蛋白重链（IgH）基因重排检测的应用价值。

Aim : To explore the value of detection of IgH rearrangement in peripheral blood detection of B cell lymphoma ( B-NHL ) patients .

目的比较常规细胞遗传学（CC），间期荧光原位杂交（FISH）技术及连续R显带后FISH检测免疫球蛋白重链（IgH）基因重排的应用价值。

Objective The objectives of this study was to compare the value of conventional cytogenetics ( CC ), interphase FISH and sequential R-banding and FISH as methods for detecting IgH gene rearrangements .

牛免疫球蛋白重链基因中JH，Eμ片段敲除的研究和JH，Cμ基因的分析

The Research of Gene Targeting of the Bovine Immunoglobulin Heavy Chain JH , E μ Locus and Analysis of JH , C μ Genes in the Bovine Germline Gene

UCD一般免疫球蛋白重链基因重排阴性，MCD基因重排部分为阳性。

The immunoglobulin gene rearrangement analysis in UCD is negative while parts of MCD cases are positive .

PCR扩增T细胞受体δ基因监测儿童急性淋巴细胞白血病微量残留病主要采用聚合酶链反应（PCR）方法，以免疫球蛋白重链和T细胞受体δ基因重排作为肿瘤标志。

Monitoring of PCR amplifying cell receptor δ gene in childhood acute lymphoblastic leukemia Minimal residual disease was traced successfully in 44 cases by polymerase chain reaction using TCR δ and IgH rearrangement genes as markers .

这一过程称为免疫球蛋白重链类型转换，是通过一个称为SS重组的过程实现的。SS重组发生于各个C基因（除Cδ外）前的S区中。

This process , referred to as heavy ( H ) chain class switching , is realized by a DNA rearrangement event called S-S recombination which occurs at the switch ( S ) region located in front of each C gene except for C δ .

目的探讨儿童急性B淋巴细胞白血病（Ball）的起源及其免疫球蛋白重链可变区（IgHV）上可被细胞毒性T淋巴细胞（CTL）识别的表位（epitope）。

Objective To investigate the origin of childhood B-cell acute lymphoblastic leukemia ( B-ALL ) and its epitopes recognized by cytotoxic T lymphocytes ( CTL ) in immunoglobulin heavy chain variable region ( IgHV ) .

VH基因序列长度为366bp，编码122个氨基酸。VH基因属于鼠免疫球蛋白重链Ⅱ亚类。

The VH gene was 366 bp in length , encoding 122 amino acid residues , belonging to the mouse Ig kappa heavy chain subgroup ⅱ .

方法用RTPCR方法扩增人免疫球蛋白重链Fd及κ链基因，构建噬菌体抗体库，筛选出人抗AFPFab片断，用ELISA检测其特异性。

Methods Human immunoglobulin heavy chain Fd genes and κ chain genes were amplified by RT PCR and phage antibody library was constructed . Human anti AFP Fab was obtained and its binding activity to AFP was tested by ELISA .

不同胎龄新生儿免疫球蛋白重链基因CDR3序列特征

Feature of immunoglobulin heavy chain complementarity determining region 3 gene in neonates with different gestational age

方法对疑难NHL病例标本21例和儿科淋巴细胞白血病治疗后残留病变标本11例进行免疫球蛋白重链（IgH）和T细胞受体（TCRβ）克隆性基因重排检测。

We began on its application to the detection of IgH and TCR clonal gene rearrangement for difficult clinical pathological diagnosis in 21 NHL and 11 residual lesions after treatment of podiatric lymphocytic leukemia .

目的：探讨初诊急性淋巴细胞白血病（ALL）患者免疫球蛋白重链（IgH）、T细胞受体γ（TCRγ）基因重排情况。

Objective : To explore the occurrence rate of rearrangements of immunoglobulin heavy chain ( IgH ) and T cell receptor γ ( TCR γ) genes in the patients with acute lymphocytic leukemia ( ALL ) .

目的对免疫球蛋白重链（IgH）及T细胞受体（TCRγ）进行基因重排分析，并对其在Lennert淋巴瘤诊断中的应用作初步探讨。

PURPOSE To investigate the significance of Ig heavy chain gene ( IgH ) and T cell receptor γ chain gene ( TCR γ) rearrangement analysis in the diagnosis of Lennert 's lymphoma .

非何杰金氏淋巴瘤的T细胞受体和免疫球蛋白重链基因重排的初步研究

T Cell Receptor and Immunoglobulin Gene Rearrangement Assays on Non-Hodgkin 's Lymphomas

用基因定点突变技术改建&免疫球蛋白重链可变区基因的通用表达载体

Reconstruction of Universal V_H Gene Expression Vector Using Oligonucleotide-directed Site Specific Mutagenesis

石蜡包埋组织恶性淋巴瘤免疫球蛋白重链基因重排研究

A Study of Clonal Rearrangement of Immunoglobulin in Paraffin-Embedded Non-Hodgkin 's Lymphoma

哺乳动物免疫球蛋白重链恒定区基因研究进展

Progress on Immunoglobulin Heavy Chain Constant Region Gene in Mammals

新生儿免疫球蛋白重链可变区基因指纹图谱分析

Analysis of the Immunoglobulin Heavy Chain Variable Region Gene Fingerprinting of Human Neonates

史氏鲟免疫球蛋白重链可变区序列及多样性

Ig heavy chain of Amur sturgeon Acipenser schrenskii : cDNA sequence and diversity