依托咪酯

依托咪酯对大鼠脑cAMP信号转导系统的影响

Effects of etomidate on cAMP signal transduction system of rat brain in vivo

依托咪酯组明显低于硫喷妥钠组（P＜0.01）。

The plasma levels of cortisol and aldosterone in etomidate group were statistically lower than those of thiopentone group ( P < 0.01 ) .

B组：以依托咪酯、芬太尼诱导，静脉推注琥珀胆碱气管插管，以芬太尼静滴维持麻醉。

Group B were induced by etomidate and fentanyl , succinylcholine intravenous blous while intubation , and maintained anesthesia by fentanyl intravenous dripped .

依托咪酯对大鼠皮质、海马cAMP含量的影响

Etomidate increases the cAMP level in cerebral cortex and hippocampus of rat brain in vivo

侧脑室注射荷包牡丹碱、NMDA对依托咪酯所致遗忘作用的影响

Effects of intracerebroventricular injection of bicuculline or NMDA on the amnestic effect induced by etomidate

依托咪酯激活大鼠骶髓后连合核神经元GABAA门控氯通道电流

Activation of GABA_ ( A ) receptor-gated chloride currents by etomidate in rat sacral dorsal commissural neurons

点斜法、序贯法测定全身麻醉诱导时依托咪酯催眠ED（50）的研究

The hypnotic ED_ ( 50 ) of etomidate determined with spot-slope method and sequential method during induction of general anesthesia

依托咪酯靶控输注用于老年患者快通道麻醉时BIS与HRV关系的研究

The Association of BIS and HRV in Target-Controlled Infusion of Etomidate Used in Fast-tracking Anesthesia of the Elderly

目的：观察丙泊酚（P）、依托咪酯（E）和异氟烷（I）对胃癌根治术病人围术期血糖和胰岛素的影响。

Objective : To study the influence of propofol ( P ), etomidate ( E ) and isoflurane ( I ) on blood glucose and insulin levels in patients of stomach carcinoma during the radical operation .

采用高效液相测定法，测定依托咪酯对去极化诱发突触体神经递质谷氨酸和GABA释放的影响。

The effects of etomidate on Glutamate and GABA release from synaptosomes were examined with inverse phase high performance liquid chromatographic methods .

本文观察一次静脉注射依托咪酯（0.3mg／kg）对小儿肾上腺皮质功能的影响。

The purpose of this paper is to assess the effect of etomidate ( 0.3 mg / kg ) on adrenocortical function in children .

依托咪酯诱导后继续短时间内用于麻醉维持，对肾上腺皮质的抑制作用超过24h，但皮质醇已经恢复到诱导前水平的60%以上。

Etomidate used in induction and maintenance can suppress adrenocortical function over 24 h , but cortisol is beyond 60 % of the baseline at 24 h after induction .

H3时点ACTH浓度升高（P<0.05），醛固酮、ACTH于H4时点基本恢复原有水平。结论依托咪酯单次麻醉诱导对肾上腺皮质的抑制作用在24h以内；

Aldosterone and ACTH has recover to the baseline at H4 . Conclusions Etomidate single dose induction can inhibit adrenocortical function but do not exceed 24 h.

结论乳腺癌新辅助化疗后患者靶控输注依托咪酯时意识消失的EC50低于未化疗患者。

Conclusion The EC50 of etomidate to cause loss of consciousness in adjuvant chemotherapy group is low than control group .

目的测定新辅助化疗乳腺癌患者靶控输注依托咪酯意识消失时的半数效应室靶浓度（EC50）。

Objective To determine the Effcet-site EC50 of etomidate to cause loss of consciousness in patients who accepted adjuvant chemotherapy .

依托咪酯的作用机制复杂，可能与NMDA受体、甘氨酸受体、γ-氨基丁酸A（GABAA）受体等有关。

The mechanism of this action may be related to NMDA receptor , glycine receptor and gamma-aminobutyric acid A ( GABAA ) receptor .

目的探讨硫喷妥钠、异丙酚、依托咪酯诱导对气管插管期间血压、脉搏及其内皮素（endothelin，ET）、一氧化氮（NitricOXide，NO）的影响。

Objective To investigate the changes of blood pressure ( Bp ), heart rate ( HR ) and endothelin ( ET ), nitric oxide ( NO ) during induction of general anesthesia by tracheal intubation with thiopental , propofol and etomidate .

采用动态光散射法、电泳光散射法、电导法和HPLC法分别检测依托咪酯脂肪乳注射液的粒度分布、ζ电位、相变温度和药物含量等理化性质。

The properties such as size distribution , zeta potential , phase inversion temperature and drug content of the etomidate fat emulsion injection were examined by the dynamic light scattering , electrophoretic light scattering , conduc - tance method and HPLC , respectively .

方法40例病人分别用异丙酚2.5mg/kg、依托咪酯0.3mg/kg行静脉麻醉。

Methods 40 cases of artificial abortion patient were treated with etomidate 0.3mg/kg and disoprofol 2.5mg/kg separately .

目的测定全身麻醉诱导时依托咪酯催眠效应半数有效量（ED50），比较点斜法、序贯法测定ED50的利弊。

Objective To determine the hypnotic ED_ 50 of etomidate with spot-slope method and sequential method during induction of general anesthesia and compare the advantages of two methods .

诱导睡眠方法：依托咪酯组：依托咪酯20mg（10ml）静脉缓注，至入深睡眠状态，停止注射，记录用药剂量；

Methods of sleeping inducing in the etomidate group : etomidate 20mg ( 10ml ) were given by vein injection slowly till patients were in deep sleep and the dosages of the agents were recorded .

方法40例胸科手术的病人，分别用两种剂型的依托咪酯0.5mg/kg剂量全麻诱导，观察心血管变化和不良反应。

Methods Forty thoracic surgery patients were included with a dose of etomidate 0.5mg/kg for general anesthesia induction they were given the same dose of two types of etomidate .

麻醉诱导期：静注咪唑安定0.06mg/kg、芬太尼3ug/kg、维库溴铵0.12mg/kg、依托咪酯0.35mg/kg。

Anesthesia induction period : intravenous midazolam 0.06mg / kg , fentanyl 3ug / kg , vecuronium 0.12mg / kg , etomidate 0.35mg/kg .

比较依托咪酯和异丙酚用于人工流产术麻醉观察效果

Comparison on effect of Etomidate Disoprofol on Anesthesia of Artificial Abortion

预注小剂量依托咪酯对肌震颤的影响

Effects of small dose of etomidate injected before induction on myoclonus

依托咪酯对兔主动脉阻断脊髓缺血性损伤的保护作用

Protective Effect of Etomidate on Ischemic Spinal Cord Injury of Rabbits

麻醉诱导用咪唑安定、依托咪酯及芬太尼。

Anesthesia was induced with midazolam , etomidate and fentanyl .

依托咪酯抗实验性惊厥作用及其机制

The antidotal effect and mechanism of etomidate on experimental convulsion in mice

依托咪酯与异丙酚用于门诊无痛人流的临床效能比较

Comparison of clinical effect between etomidate and propofol in analgesic artificial abortion

依托咪酯和咪唑安定对离体兔肺动脉的作用

Effects of etomidate and midazolam on isolated rabbit pulmonary arteries