佐匹克隆

目的研究国产佐匹克隆（ZPL）的抗惊厥作用。

AIM To study the anticonvulsant effect of domestic zopiclone ( ZPL ) .

国产佐匹克隆抗惊厥作用的实验研究

Experimental study of the anticonvulsant effect of domestic zopiclone

HPLC法测定佐匹克隆片的含量及有关物质

Determination of Zopiclone and Related Substances in Zopiclone Tablets by HPLC

目的建立测定人血浆中佐匹克隆浓度的HPLC法，比较国产与进口佐匹克隆片剂的药动学。

AIM To develop a HPLC-UV method for determinating the concentration of zopiclone in human plasma and to compare the pharmacokinetics of zopiclone tablets of domestic vs imported .

结论：本法可用于测定合成右旋佐匹克隆过程中对映体过量（ee）和右旋佐匹克隆中手性杂质的含量[1]。

Conclusion : The established method is suitable for the determination of chiral impurity and enantiomer excess in the d-zopiclone .

目的探讨佐匹克隆（zpl）对大鼠戊四唑（PTZ）化学点燃和对小鼠氨基脲惊厥的影响。

Objective To study the effect of zopiclone on pentylenetetrazole ( PTZ ) - kindling in rats and semicarbazide-induced convulsion in mice .

结论本法适合于人体佐匹克隆血药浓度测定，国产与进口佐匹克隆片剂生物等效。

The domestic zopiclone tablet is equivalent to imported one .

结果：找到了反相高效液相色谱拆分佐匹克隆对映体的最佳色谱条件。

Results : The best analytic condition was found .

目的探讨血清中佐匹克隆的测定方法。

Objective To determine the zopiclone concentration in serum .

佐匹克隆对大鼠杏仁核点燃的作用

Effects of zopiclone on the amygdala kindling in rats

目的建立佐匹克隆溶剂残留的顶空气相色谱法。

Objective To establish a method for the determination of residual solvent in Zopiclone .

β-环糊精用于毛细管电泳拆分佐匹克隆对映体的研究

Chiral Separation of Zopiclone by Capillary Electrophoresis with β - Cyclodextrin as Chiral Selector

目的验证国产佐匹克隆对失眠症的有效性和安全性。

Objective To evaluate the clinical curative effects and the side effects of zopiclone on insomnia .

目的建立右旋佐匹克隆中手性杂质含量的测定方法。

Objective To develop a reversed-phase HPLC method so as to determine the chiral impurity content in the S-zopiclone .

认知行为疗法与佐匹克隆治疗老年慢性原发性失眠患者的比较：一项随机对照试验

Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults : A randomized controlled trial

单指标减分值比较，除扎来普隆组前4天的睡眠质量较佐匹克隆组低，有统计学意义以外，其余各指标差别无统计学意义。

Comparing the value reduction of single marker of SDRS between'two groups , no statistical significance , excluding the quality of sleep at the 4th day of treatment .

应用薄层荧光扫描法测定了动物血浆中佐匹克隆的浓度，并对佐匹克隆在中毒家兔体内的分布进行了研究。

A method is reported for the detection and analysis of zopiclone concentration in plasma by thin-layer chromatography-fluorometry and used to study the distribution of zopiclone in poisoned rabbits .