二肽酶

α-天门冬氨酰二肽酶及其进化酶的FT-IR研究

FT-IR studies of α - aspartyl dipeptidase and its evolutional enzyme

肽基二肽酶A；基因缺失；高血压；

Peptidyl dipeptidase A Gene deletion Hypertension Pregnancy complications ;

该肽对酶降解十分敏感，特别是对二肽酶Ⅳ（DPPⅣ）最为敏感，二肽酶Ⅳ（DPPⅣ）介导的这种蛋白水解作用是GHRH在体内降解、失活的主要途径。

This peptide is very sensitive to the degeneration of enzyme , especially the dipeptidyl peptidase ⅳ ( DPP ⅳ) . Protein hydrolyzation mediated by dipeptidyl peptidase ⅳ ( DPP ⅳ) is the mainly cause resulting in the degeneration and invalidation of GHRH in vivo .

氨酰基脯氨酸二肽酶缺乏症的诊断和治疗

The Diagnosis and Treatment of Prolidase Deficiency

目的报道一例罕见的氨酰基脯氨酸二肽酶缺乏症及其诊断治疗方法。

Objective To report a rare case of prolidase deficiency and the methods of diagnosis and treatment .

西司他丁是一种肾脱氢二肽酶抑制剂，其与亚胺培南复配的抗菌药物&泰能在临床上应用广泛。

Cilastatin is an important inhibitor of dehydropeptidase-I , which can enhance the antibacterial activity of Imipenem and has widely clinic applications .

结果：1在儿童唾液中仅能测得甘氨酰脯氨酸二肽酶和胰酶样蛋白酶，且其活性明显低于牙菌班中的酶活性（P<0.05）；

Results : ① Only dipeptidyl peptidase ⅳ and trypsin like proteinase were demonstrated in saliva , they were obviously lower than those in dental plaque ( P < 0.05 );

结果发现，亮氨酸氨肽酶和甘氨酰脯氨酸二肽酶和胰酶样蛋白酶存在于根面菌斑中，且均有一定的活性。

The results indicated that three enzymes were present in the root surface plaque , namely leucine amino peptidase , dipeptidyl peptidase ⅳ and trypsin like proteinase , and their activities were different .

二肽肽酶IV抑制剂的三维定量构效关系研究

Quantitative Structure-activity Relationship of Dipeptidyl Peptidase IV Inhibitors

目的探讨二肽肽酶IV（DPPIV）基因在卵巢癌细胞系中的表达并分析其与卵巢癌细胞恶性行为的关系。

Objective To study the relationship between the expression of dipeptidyl peptidase IV ( DPP IV ) gene and malignant behavior of cells of ovarian carcinoma .

最初因发现它具有蛋白水解作用，故又称二肽肽酶IV（DPPIV）。

It has been determined to be proteolytic enzyme , known as dipeptidyl peptidase IV ( DPPIV ) .

含噻唑环的二肽基肽酶IV抑制剂的设计、合成和降血糖活性研究

Design , Synthesis and Anti-diabetic Activities of Thiazole-Bearing Compounds as Dipeptidyl Peptidase IV Inhibitors

目的研究联合检测甘氨酰脯氨酸二肽氨基肽酶（GPDA）及其同工酶、腺苷脱氨酶（ADA）对不同性质腹水的鉴别诊断价值。

Objective To study the value of GPDA and its isoenzymes as well as ADA in the differential diagnosis of ascites .

目的建立甘氨酰脯氨酰二肽氨基肽酶（GPDA）自动化分析方法。

Objective To establish a kinetic monitoring assay for detecting glycylproline dipeptidyl aminopeptidase ( GPDA ) . Methods Gly-pro-pNA .

目前对长效的GLP-1类似物、二肽基肽酶Ⅳ抑制剂和GLP-1基因治疗的研究已成为热点。

Recently , the long acting GLP-1 analogs , dipeptidyl peptidase IV inhibitors and GLP-1 gene therapy have become the hot topics .

目的探讨血清微量元素、苷氨酰脯氨酸二肽氨基肽酶活性（GPDA）和幽门螺杆菌（Hp）感染与胃癌发生的关系。

Objective To study the relationships of gastric cancer with serum trace elements , glycyl proline dipeptidyl aminoeptidase ( GPDA ) and infected by helicobacter pylori ( Hp ) .

探讨乳腺癌患者血清甘氨酰脯氨酸二肽氨基肽酶（GPDA）活性的变化及其应用价值。

To investigate the activity of serum glycylproline dipeptidyl aminopeptidase ( GPDA ) in patients with breast cancer and its clinical value .

目的合成甘氨酰脯氨酸二肽氨基肽酶（GPDA）的底物甘氨酰脯氨酰对硝基苯胺对甲苯磺酸盐，并探讨其临床应用。

Objective To synthesize glycylproline p-nitroanilide tosylate as a substrate for glycylprolyl dipeptidyl-aminopeptidase ( GPDA ), and to study its clinical application .

治疗2型糖尿病药物二肽基肽酶Ⅳ（DPP-4）抑制剂的研究进展

Progress in research of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes

观察血清甘氨酰脯氨酸二肽氨基肽酶（GPDA）在慢性肝病中的变化，评价临床诊断价值。

To study the variation of serum glycyl-proline dipeptidyl aminopeptidase ( GPDA ) in chronic liver diseases and to evaluate its clinical diagnosis value .

目的：研究联合检测血清甘氨酰脯氨酸二肽氨基肽酶（GPDA）同工酶和甲胎蛋白（AFP）对原发性肝癌的诊断价值。

Objective : To study the value of simultaneous determination of serum alpha-fetoprotein ( AFP ) and glycylproline dipeptidyl aminopeptidase ( GPDA ) isoenzymes to the diagnosis of primary hepatocellular carcinoma .

目的：探讨甘氨酰脯氨酸二肽氨基肽酶（GPDA）在食管贲门癌组织中的变化规律。

Objectives : To explore the change rule and clinical value of glycylproline dipeptidyl aminopeptidase ( GPDA ) in tissues of esophageal and cardiac cancers .

二肽基肽酶Ⅳ抑制剂（？）（dipeptidylpeptidase-4inhibitor，DPP-Ⅳ抑制剂）就是目前开发的一种新的、有效的降糖药之一。

Dipeptidyl peptidase ⅳ inhibitor ( dipeptidyl peptidase-4 inhibitor , DPP - ⅳ inhibitors ) is currently developing a new , efficient one of hypoglycemic agents .

背景与目的：血清甘氨酰脯氨酸二肽氨基肽酶同工酶快带（fastbandofglycylprolinedipeptidylaminopeptidaseisoenzyme，GPDA-F）有助于肝癌尤其是甲胎蛋白阴性肝癌的诊断。

BACKGROUND & OBJECTIVE : Serum fast band of glycylproline dipeptidyl aminopeptidase isoenzyme ( GPDA-F ) is useful to the diagnosis of hepatocellular carcinoma , especially for the cases without expression of alpha-fetoprotein ( AFP ) .

抑制二肽基肽酶-4（DPP-4，属于丝氨酸脯氨酰寡肽酶家族）具有延长和增强肠促胰岛素活性的作用，其在调节胰岛素分泌和控制血糖方面发挥着重要作用。

Inhibition of the dipeptidyl peptidase-4 ( DPP-4 ), a member of the prolyl oligopeptidase family of serine protease , prolongs and enhances the activity of incretins that play an important role in insulin secretion and blood glucose control regulation .

综述以二肽基肽酶Ⅳ为靶点的抗糖尿病药物。

The related antidiabetics targeted on dipeptidyl peptidase ⅳ were reviewed .

金华火腿加工过程中二肽酰肽酶Ⅰ的活性变化

Changes of dipeptidyl peptidase ⅰ activity during the processing of Jinhua ham

二肽基肽酶Ⅲ在不同周龄正常大鼠晶状体中的表达

The Expression of Dipeptidyl Peptidase ⅲ in Normal Rat Lenses of Different Weeks

甘氨酰脯氨酸二肽氨基肽酶检测技术及临床应用研究

Determination of glycylproline dipeptidyl aminopeptidase and its clinical applications

肝癌相关性甘氨酰脯氨酸二肽氨基肽酶检测法

Detection of hepatoma - associated glycylproline dipeptidyl aminopeptidase