毛果芸香碱

毛果芸香碱治疗精神药物所致口干的临床对照研究

A Controlled Clinical Study of Pilocarpine Nitrate in the Treatment of Dry Mouth Caused by Psychotropic Drugs

目的：建立毛果芸香碱诱导的小鼠急性癫痫模型，并探讨其特点。

AIM : To establish the mouse models with acute epilepsy induced by pilocarpine , and explore the characteristics .

M受体激动剂毛果芸香碱能产生与ACh相似的效应。

The M receptor agonist pilocarpine was similar to the effects of ACh .

另取肠段按毛果芸香碱、阿托品或SCS、再毛果芸香碱的顺序给药，观察嗜酸乳杆菌SCS对M型胆碱受体的作用。

The effect of SCS on M cholinoceptor was observed by adding in order pilocarpine , atropine or SCS , and pilocarpine .

毛果芸香碱致癎大鼠脑内胶质细胞源性神经营养因子及其受体α和Ret蛋白的表达

Expressions of GDNF , GDNFR α and Ret proteins in the brain of rats with seizures induced by pilocarpine

目的：观察小鼠毛果芸香碱（pilocarpine，PC）致惊后不同时间海马活化素βamRNA的表达，探讨其作用机制。

OBJECTIVE : To observe hippocampal activin β A mRNA expression at different time point after pilocarpine ( PC ) - induced epilepsy in mouse to explore its mechanism .

方法采用毛果芸香碱诱导的SE小鼠模型，应用逆转录聚合酶链反应（RTPCR）及原位杂交观察SE后海马活化素βA基因表达的动态变化；

Methods The pilocarpine ( PC ) - induced mouse SE model was used . RT-PCR and hybridization in situ were used to observe the dynamical expression pattern of activin β A.

观察ACh、阿托品、毛果芸香碱对LC中神经元形态学改变的影响。

The morphological changes of neurons in LC by the influence of ACh , atropine , and pilocarpine were observed in the end of the experiment .

毛果芸香碱对ETA呈非竞争性拮抗作用，可作为区分ETA和M受体的工具药。

The antagonism of pilocarpine was fit for noncompetitive . Pilocarpine will be used as a marker of distinguishing different between ETA and M receptors . 3 .

结果结扎并毛果芸香碱刺激后，结扎侧犬颌下腺T2驰豫时间较刺激前显著升高，与结扎对例及同侧毛果芸香碱刺激前比较有显著差异；

Results After ductal ligation and stimulation by pilocarpine , the T2 relax time had obviously increased . There was significant difference in comparing with the other side and the same side before stimulation .

眼用药膜中毛果芸香碱及其降解产物的高效液相色谱测定

HPLC determination of pilocarpine and its degradation products in ophthalmic films

下丘注射去甲肾上腺素和毛果芸香碱对大鼠听源性癫痫发作的影响

Effects of NE and Pilocarpine Bilateral Inferior Colliculi Injection on Audiogenic Seizures

构建毛果芸香碱急性致痫小鼠模型

Establishing the mouse models of acute epilepsy induced by pilocarpine

硝酸毛果芸香碱温敏凝胶的研制及溶蚀性能研究

Preparation of pilocarpine thermosensitive gel and study on dissolution performance

硝酸毛果芸香碱原位凝胶滴眼剂的制备及体外释放度评价

Preparation and in Vitro Release of Ophthalmic in-situ Gels of Pilocarpine Nitrate

硝酸毛果芸香碱脂质体滴眼液的研究跨膜梯度法制备羟苯磺酸铵-盐酸阿霉素脂质体

Loading of doxorubicin hydrochloride into liposomes by ammonium dobesilate transmembrane gradient method

结果发现毛果芸香碱也是血小板聚集的抑制剂。

The results showed that pilocarpine was also an inhibitor of platelet aggregation .

硝酸毛果芸香碱温敏型眼用脂质体凝胶的制备及体外释放

Preparation of pilocarpin nitrate thermosensitive ocular liposomal gel and its release in vitro

4%毛果芸香碱凝胶对寻常型天疱疮皮损的治疗效果

Healing effect of Pilocarpine gel 4 % on skin lesions of pemphigus vulgaris

毛果芸香碱促进培养的兔泪腺上皮细胞蛋白合成和分泌

Pilocarpine increased synthesis and secretion of protein in cultured rabbit lacrimal epithelial cells

毛果芸香碱致慢性癫大鼠脑内药物转运体表达的变化

Changes of Drug Transporters Expression in Brains of Chronic Epileptic Rats Induced by Lithium-Pilocarpine

插管后第3天腹腔注射毛果芸香碱诱导小鼠癫痫模型。

After three days of cannulation , the mice were induced epileptic with pilocarpine .

毛果芸香碱凝胶治疗青光眼的临床效果观察

A clinical observation of the therapeutic effects of pilocarpine gel for treatment of glaucoma

辐射聚合制备毛果芸香碱&水凝胶释放体系的研究

Study on Radiation-Polymerization For Pilocarpine-Hydrogel Slow Release System

毛果芸香碱微乳滴眼剂及滴眼液在兔眼房水中的药代动力学研究

Ocular pharmacokinetics of pilocarpine micron emulsion in rabbits

目的比较新斯的明、毒扁豆碱和毛果芸香碱对兔眼的缩瞳作用。

Objective To compare the myotic effects of physostigmine , pilocarpine and neostigmine in rabbits .

目的：观察玻璃酸钠对硝酸毛果芸香碱滴眼液的影响。

Object : To observe the influence of sodium hyaluronic acid to pilocarpin hydrochloride eyedrops .

毛果芸香碱对映体的毛细管电泳手性分离

Chiral Separation of Pilocarpine by Capillary Electrophoresis

2%毛果芸香碱透明质酸钠控释膜对高眼压兔的降眼压作用雄兔脚扑朔雌兔眼迷离

Effects of 2 % Pilocarpine Membrane with Sodium Hyaluronate on Intraocular Pressure in Rabbits with Ocular Hypertension

乙酰胆碱、阿托品、毛果芸香碱在痛觉调制中对大鼠蓝斑核神经元形态的影响

Influence of acetylcholine , atropine , and pilocarpine on the morphologies of neurons in locus ceruleus of rats in the algesic modulation