二室模型

min。结论：灯盏细辛注射液中的总咖啡酯类成分在大鼠体内过程符合静脉注射二室模型。

Conclusion : The pharmacokinetics model of coffeic acid esters is two-compartment model after iv Erigeron injection in Sprague-Dawley rats .

理论上，对于一室开放形模型，按（1）式计算ka是精确的；对于二室模型则仅提供ka的一个初步估计。

Theoretically , for one-compartment open model , use formula ( 1 ) to calculate k_a is correct , while for two-compartment model , it only gives a rough estimate of k_a .

大鼠iv自制紫杉醇纳米乳剂及紫杉醇注射液后的药时曲线均符合二室模型。

The concentration time curve of paclitaxel microemulsion and commercial injection ( Taxol ) fitted a two compartment model .

~3H&小檗碱家兔ig、iv后，血药时程曲线符合二室模型。

After ig and iv 3H-berberine in rabbits , the plasma radioactivity-time cure was found to be 2-compartment open model .

PK属于开放性二室模型。

PK : open bicameral model .

按实验设计采集6h内动态血样，以HPLC法测定血浆药物浓度，以静脉注射二室模型计算药代动力学参数。

Blood samples were collected during 6 hours in accordance with the experimental design . The drug levels in plasma were measured by HPLC assay .

姜黄素溶液和姜黄素PLGA纳米混悬液在血液中的药动学行为均可用二室模型描述（权重为1）。

The pharmacokinetic characteristics of curcumine solution and Cur-PLGA-NPs in rats could be described as two-compartment model ( weight 1 ) .

结果三七总皂苷混悬液鼻腔给药后，Rg1在大鼠体内的过程符合二室模型，其绝对生物利用度为10356%；

Results The in vivo course of Rg1 in rats conformed to two-compartment model after intranasal administration of PNS suspension and the absolute bioavailability was 103.56 % .

根据药物动力学的二室模型计算了131I治疗甲亢时体内131I的吸收与分布，计算与实验测量结果基本一致。

According to pharmacokinetics two-compartment model , we have calculated out that the dose was absorbed and distributed by hypothyroid ; the experimental and calculated results are almost consistent .

Beagle犬静脉注射亚硫酸氢钠穿心莲内酯后的药动学行为符合二室模型。

After intravenous injections of 50 , 40 , 20 mg · kg - 1 of andrographolide sodium bisulphite in beagle dogs , the concentration-time curve was fitted to a two compartment model .

结果：雏鸡口服罗红霉素的药时数据符合一级吸收二室模型，低剂量加桔梗组（8mg／kg）的C（max）值显著高于单用RM组（P＜0.05）；

Results : The blood concentration-time data roxithromycin in plasma fitted to two compartment model with 1st order absorption . The Cmax values of the experimental groups were significantly higher than those of the control groups , respectively ( P < 0.05 ) .

结果显示APIC在大鼠体内的药动学过程均符合二室模型，且在本实验所采用剂量范围内AUC随着剂量的增加也相应增大。

The concentration-time curves of APIC in rats were fitted to two-compartment model and the AUC increased accordingly as the accrescence of the dosage in the dosage range chose in this experiment .

6mg.L-1时平均回收率分别为102.5%、101.7%和101.9%，日内RSD、日间RSD分别为（3.9±1.4）%和（3.1±2.4）%，药-时曲线显示两制剂符合二室模型。

The average RSD of within-day and between-day were ( 3.9 ± 1.4 ) % and ( 3.1 ± 2.4 ) % , respectively . The results showed that the concentration-time curves of the two preparations were fitted to a two-compartment model .

目的在体内C肽动力学二室模型及标准参数法基础上，计算多次取样的静脉糖耐量试验（FSIVGTT）中胰岛素分泌率（ISR）。

Objective To measure and calculate insulin secretion rate ( ISR ) in multiple sampled intravenous glucose tolerance test ( FSIVGTT ) according to the two compartment model and standard parameters of the kinetics of connecting peptide ( C P ) in vivo .

在家兔体内的药物动力学过程符合二室模型，与阿糖胞苷注射剂相比，t1/2β和MRT延长，CL降低，表明阿糖胞苷纳米粒可显著延长阿糖胞苷在体内存留时间，具有明显的缓释特征。

The pharmacokinetics in rabbits complied with two-department model . Compared with cytarabine injection , cytarabine nanoparticle had prolonged t_ ( 1 / 2 )β and MRT and reduced CL , which showed nanoparticle could significantly prolong the retention time of Ara-C and possess significant sustained releasing character .

结果：药后5min即可从血液中测到放射性，血液药时曲线符合开放型二室模型；

[ WT5HX ] Results : [ WT5BZ ] Radioactivity was found in blood at 5 minute after administration . The blood concentration time curve was shown to fit a two compartment open model .

结果：兔灌胃及静注Ani后其药动学行为符合二室模型，属快分布型药物，Fabs为6.36%。

ZHU program on microcomputer . Results : A two compartment open model featured the pharmacokinetic process after iv or ig Ani in rabbits , belong to fast distribution drug , absolute bioavailability is 6.36 % . ( 2 ) C shape ;

对10名健康志愿者口服azithromycin的药物动力学研究以及其干糖粉的相对生物利用度测定结果显示：空腹口服azithromycin单剂500mg后，其体内过程符合二室模型，其消除半衰期为50.39±8.87h；

The pharmacokinetics of azithromycin and the bioavailability of its dry syrup in 10 healthy volunteers were described in this paper . After a single oral dose of 500 mg azithromycin administration in fasting state , the serum concentration time curves appeared to fit a two compartment model kinetics .

具有时滞效应二室模型的药物动力学分析

Drug kinetic analysis of two-compartment model with time lag effect

结果：血药浓度-时间曲线为二室模型。

RESULTS : The concentration-time curves of ziprasidone fitted to two-compartment model .

结果厄贝沙坦的血药浓度时间曲线呈二室模型；

Results The pharmacokinetic profiles were best fitted a two-compartment open model .

本药物在家兔体内显示为二室模型。

Diclofenac sodium in the animal plasma was show a two-compartment open model .

血浆药物清除曲线符合二室模型。

The plasma drug elimination curve was concordant with a two compartment model .

结论天麻素注射液的人体药动学符合药动学二室模型。

Conclutions The pharmacokinetics of gastrodin injection in volunteers was accorded with two compartment model .

二室模型药物静注十静滴的给药方案计算

Dosage regimen calculation of " intravenous injection + intravenous infusion " for two compartment model drugs

结果显示总铂在血浆中的药代动力学模式为二室模型。

The initial results showed that the pharmacokinetics of total platinum in plasma assumed two-compartment mode .

针对二室模型的渔药休药期计算软件设计

Software R & D for calculating the withdrawal time of fishing drugs as for two-compartment model

结论：双黄连粉针中绿原酸在大白鼠体内呈二室模型分布。

CONCLUSION : The chlorogenic acid in shuanghuanglian powder injection shows two-compartment in the body of the rat .

结果钆喷酸葡胺及其脂质体在小鼠体内的血药时程变化符合二室模型。

Results The concentration time curves of them in mice could be fitted to two compartment open models .

静脉注射后的血药浓度-时间曲线符合开放型二室模型；

Post-infusion serum drug concentration versus time curve was fitted to two-compartment open model with first order elimination .